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1.发明申请METHOD AND SYSTEM FOR NUCLEATION CONTROL IN A CONTROLLED RATE FREEZER (CRF) 有权控制速度冻结机（CRF）中核心控制的方法与系统公开(公告)号：US20120102982A1
公开(公告)日：2012-05-03
申请号：US13097724
申请日：2011-04-29
申请人： Ying Zhou , Theodore H. Gasteyer, III , Nigel J. Grinter , Alan T. Cheng , Yeu-Chuan Simon Ho , Robert R. Sever
发明人： Ying Zhou , Theodore H. Gasteyer, III , Nigel J. Grinter , Alan T. Cheng , Yeu-Chuan Simon Ho , Robert R. Sever
CPC分类号： A01N1/0289 , A01N1/0257 , A01N1/0284 , F25D3/102 , F25D29/001
摘要： A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time. The presently disclosed methods to systems also provide nucleation control via temperature quench and depressurized nucleation control.
摘要翻译： 提供了控制速率冷冻和成核的方法和系统。 本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的材料的能力，其中使用层流和均匀流动的冷冻剂靠近设置在冷却单元内的多个小瓶。 生物材料的快速冷却是通过精确地控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。 目前公开的系统方法还通过温度骤冷和减压成核控制提供成核控制。
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2.发明授权Method and system for nucleation control in a controlled rate freezer (CRF) 有权控制率冷冻机（CRF）中成核控制的方法和系统公开(公告)号：US08794013B2
公开(公告)日：2014-08-05
申请号：US13097724
申请日：2011-04-29
申请人： Ying Zhou , Theodore H. Gasteyer, III , Nigel J. Grinter , Alan T. Cheng , Yeu-Chuan Simon Ho , Robert R. Sever
发明人： Ying Zhou , Theodore H. Gasteyer, III , Nigel J. Grinter , Alan T. Cheng , Yeu-Chuan Simon Ho , Robert R. Sever
CPC分类号： A01N1/0289 , A01N1/0257 , A01N1/0284 , F25D3/102 , F25D29/001
摘要： A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time. The presently disclosed methods to systems also provide nucleation control via temperature quench and depressurized nucleation control.
摘要翻译： 提供了控制速率冷冻和成核的方法和系统。 本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的材料的能力，其中使用层流和均匀流动的冷冻剂靠近设置在冷却单元内的多个小瓶。 生物材料的快速冷却是通过精确地控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。 目前公开的系统方法还通过温度骤冷和减压成核控制提供成核控制。
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3.发明授权Method and system for regulating the mixture of cryogen liquid and warm gas for a controlled rate cryogenic chiller or freezing system 有权用于调节低温冷冻机或冷冻系统的冷冻液和暖气混合物的方法和系统公开(公告)号：US08820097B2
公开(公告)日：2014-09-02
申请号：US13097763
申请日：2011-04-29
申请人： Alan T. Cheng , Yeu-Chuan Simon Ho , Ying Zhou
发明人： Alan T. Cheng , Yeu-Chuan Simon Ho , Ying Zhou
CPC分类号： A01N1/0257 , A01N1/0284 , A01N1/0289 , F25D3/102 , F25D29/001
摘要： A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time. The presently disclosed methods to systems also provide nucleation control via temperature quench and depressurized nucleation control.
摘要翻译： 提供了控制速率冷冻和成核的方法和系统。 本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的材料的能力，其中使用层流和均匀流动的冷冻剂靠近设置在冷却单元内的多个小瓶。 生物材料的快速冷却是通过精确地控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。 目前公开的系统方法还通过温度骤冷和减压成核控制提供成核控制。
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公开(公告)号：US20120102977A1
公开(公告)日：2012-05-03
申请号：US13097763
申请日：2011-04-29
申请人： Alan T. Cheng , Yeu-Chuan Simon Ho , Ying Zhou
发明人： Alan T. Cheng , Yeu-Chuan Simon Ho , Ying Zhou
IPC分类号： F17C5/02
CPC分类号： A01N1/0257 , A01N1/0284 , A01N1/0289 , F25D3/102 , F25D29/001
摘要： A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time. The presently disclosed methods to systems also provide nucleation control via temperature quench and depressurized nucleation control.
摘要翻译： 提供了控制速率冷冻和成核的方法和系统。 本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的材料的能力，其中使用层流和均匀流动的冷冻剂靠近设置在冷却单元内的多个小瓶。 生物材料的快速冷却是通过精确控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。 目前公开的系统方法还通过温度骤冷和减压成核控制提供成核控制。
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5.发明申请A METHOD AND SYSTEM FOR CRYOPRESERVATION TO ACHIEVE UNIFORM VIABILITY AND BIOLOGICAL ACTIVITY 审中-公开用于实现均匀可行性和生物活性的方法和系统公开(公告)号：US20130111931A1
公开(公告)日：2013-05-09
申请号：US13457879
申请日：2012-04-27
申请人： Nigel J. Grinter , Alan T. Cheng , Ying Zhou
发明人： Nigel J. Grinter , Alan T. Cheng , Ying Zhou
CPC分类号： F25D13/00 , A01N1/0252 , A01N1/0257 , B01L1/025 , B01L7/50 , B01L2300/0829 , B01L2300/14 , B01L2300/1838 , F25D3/10 , F25D3/102 , F25D29/001 , F25D2600/06
摘要： A method and system for controlled rate freezing and nucleation of biological materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling and optionally simultaneous pressure drop using uniform and unidirectional flow of cryogen in proximity to the plurality of vials disposed within a cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as well as the chamber pressure as a function of time.
摘要翻译： 提供了一种控制速率冷冻和生物材料成核的方法和系统。 本公开的系统和方法提供了通过强制对流冷却快速冷却冷却单元内的小瓶或其他容器中所含的材料的能力，以及使用均匀且单向的冷冻剂流在靠近设置在一个 冷却单元。 生物材料的快速冷却是通过精确控制和调节引入系统的冷冻剂的温度以及作为时间的函数的室压力来实现的。
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公开(公告)号：US20140356852A1
公开(公告)日：2014-12-04
申请号：US14096609
申请日：2013-12-04
申请人： Alan T. Cheng , Ying Zhou
发明人： Alan T. Cheng , Ying Zhou
IPC分类号： C12M1/36
摘要： A method and apparatus for micro-aeration of large scale fermentation systems is provided. The micro-aeration system includes a fermentation reactor, a sparging apparatus, and a micro-aeration gas mixture delivered to the fermentation reactor via the sparging apparatus. The micro-aeration gas mixture is a very low oxygen concentration mixture comprising: (i) an oxygen containing gas; and (ii) an inert carrier gas or reactive carrier gas that is recycled through the fermentation reactor. The gas mixture is introduced to the fermentation reactor at a minimum superficial velocity of about 0.04 m/sec to produce a uniform dispersion of the oxygen throughout the fermentation broth while concurrently mixing the entire fermentation broth. For a reactive gas consuming fermentation process, the amount of reactive carrier gas included as part of the gas mixture exceeds the reaction stoichiometric requirements in order to provide sufficient dispersion and agitation of the broth.
摘要翻译： 提供了一种用于大规模发酵系统微通气的方法和装置。 微曝气系统包括通过喷射装置输送到发酵反应器的发酵反应器，喷射装置和微通气气体混合物。 微通气气体混合物是非常低的氧浓度混合物，其包含：（i）含氧气体; 和（ii）通过发酵反应器再循环的惰性载气或反应性载气。 将气体混合物以约0.04m / sec的最小表观速度引入发酵反应器，以在整个发酵液中同时混合氧气，以均匀分散氧气。 对于反应性气体消耗发酵方法，作为气体混合物的一部分包含的反应性载体气体的量超过反应化学计量要求，以便提供肉汤的足够的分散和搅拌。
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公开(公告)号：US20130323714A1
公开(公告)日：2013-12-05
申请号：US13908462
申请日：2013-06-03
IPC分类号： C12M1/00
摘要： A method and apparatus for micro-aeration of large scale fermentation systems is provided. The micro-aeration system includes a fermentation reactor, a sparging apparatus, and a micro-aeration gas mixture delivered to the fermentation reactor via the sparging apparatus. The micro-aeration gas mixture is a very low oxygen concentration mixture comprising an oxygen containing gas and an inert carrier gas that is preferably recycled through the fermentation reactor. The inert carrier gas is preferably nitrogen whereas the oxygen containing gas is oxygen or and is introduced to the fermentation reactor at a minimum superficial velocity of about 0.02 m/sec to produce a uniform dispersion of the oxygen/air throughout the fermentation broth while concurrently mixing the entire fermentation broth. The micro-aeration method and apparatus further comprises a controller operatively coupled to one or more control valves for regulating the micro-aeration conditions in the fermentation reactor.
摘要翻译： 提供了一种用于大规模发酵系统微通气的方法和装置。 微曝气系统包括通过喷射装置输送到发酵反应器的发酵反应器，喷射装置和微通气气体混合物。 微通气气体混合物是包含含氧气体和惰性载气的非常低的氧浓度混合物，其优选通过发酵反应器再循环。 惰性载气优选为氮气，而含氧气体为氧气，或以约0.02m / sec的最小表观速度引入发酵反应器，以产生氧气/空气在整个发酵液中的均匀分散，同时混合 整个发酵液。 微曝气方法和装置还包括操作地耦合到一个或多个控制阀的控制器，用于调节发酵反应器中的微通气条件。
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8.发明申请SYSTEM AND METHOD FOR CRYOGENIC COOLING OF A PROCESS STREAM WITH ENHANCED RECOVERY OF REFRIGERATION 审中-公开具有加强制冷恢复的工艺流程的低温冷却系统和方法公开(公告)号：US20140000310A1
公开(公告)日：2014-01-02
申请号：US13884708
申请日：2011-11-08
申请人： Alan T. Cheng , De-Cheng Xie Xie , Zhijie Sun
发明人： Alan T. Cheng , De-Cheng Xie Xie , Zhijie Sun
IPC分类号： F25J3/06
摘要： A system and method for improved cryogenic cooling of process gases is provided. The disclosed system and method provides for the cryogenic cooling of a silane and hydrogen gas process stream during the manufacture of polysilicon with concurrent recovery of refrigeration capacity from the vaporized nitrogen as well as the recovery of refrigeration capacity from the cold hydrogen gas stream. The improved cryogenic cooling system and method reduces the overall consumption of liquid nitrogen without sacrificing cooling performance of the cryogenic cooling of the silane and hydrogen gas process stream.
摘要翻译： 提供了一种用于改善工艺气体的低温冷却的系统和方法。 所公开的系统和方法提供了在制造多晶硅期间硅烷和氢气工艺流的低温冷却，同时从蒸发的氮气中回收制冷量，以及从冷氢气流中回收制冷量。 改进的低温冷却系统和方法降低了液氮的总体消耗，而不牺牲硅烷和氢气工艺流的低温冷却的冷却性能。
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公开(公告)号：US5394827A
公开(公告)日：1995-03-07
申请号：US272978
申请日：1994-07-15
申请人： Alan T. Cheng
发明人： Alan T. Cheng
CPC分类号： B01J19/26 , B01D9/0009 , B01J8/226 , Y10T117/10 , Y10T117/1024 , Y10T117/1096
摘要： A direct contact cryogenic crystallizer having a vertically oriented draft tube into which cryogenic fluid is injected at a high velocity along with warm gas and through which a crystal slurry is drawn for subsequent cooling and agitation for the production of crystals.
摘要翻译： 一种直接接触式低温结晶器，其具有垂直定向的导流管，低温流体与暖气一起以高速注入其中，并通过该低温液体引入晶体浆液用于随后的冷却和搅拌以产生晶体。
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10.发明申请公开(公告)号：US20120295248A1
公开(公告)日：2012-11-22
申请号：US13475294
申请日：2012-05-18
申请人： Alan T. Cheng
发明人： Alan T. Cheng
CPC分类号： C12M27/02 , B01F3/04609 , B01F7/0065 , B01F15/00175 , B01F15/0022 , B01F15/00344 , B01F15/00389 , B01F15/0085 , C12M29/24
摘要： A disposable mixing vessel incorporates a system for dynamic gas control. The disposable mixing vessel includes a first agitating element and a second agitating element located above the first agitating element. The system for dynamic gas control enables a cell culture process to occur in the disposable mixing vessel while maintaining certain parameters of the liquid medium to be within a desired range. Such parameters may include the level of dissolved carbon dioxide, the level of dissolved oxygen, the pH and the osmolality. The system for dynamic gas control may control gas inlet and outlet ports in the disposable mixing vessel for sweeping a suitable composition of gas across the headspace of the liquid medium.
摘要翻译： 一次性混合容器包括用于动态气体控制的系统。 一次性混合容器包括位于第一搅拌元件上方的第一搅拌元件和第二搅拌元件。 用于动态气体控制的系统使得能够在一次性混合容器中发生细胞培养过程，同时保持液体介质的某些参数在期望的范围内。 这些参数可以包括溶解的二氧化碳的水平，溶解氧的水平，pH和重量摩尔渗透压浓度。 用于动态气体控制的系统可以控制一次性混合容器中的气体入口和出口，用于在液体介质的顶部空间上扫过合适的气体组成。
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