公开(公告)号：US20060062732A1

公开(公告)日：2006-03-23

申请号：US11223118

申请日：2005-09-12

Applicant: Yasumi Uchida ,  Haruko Uchida

Inventor： Yasumi Uchida ,  Haruko Uchida

IPC: A61K49/00 ,  A61B10/00

CPC classification number: A61B5/0071 ,  A61B1/043 ,  A61B1/3137 ,  A61B5/0084 ,  A61B5/02007 ,  A61K49/0021 ,  A61K49/0028 ,  A61K49/006

Abstract: The present invention provides a medicine and an apparatus which can detect the sites and spreading of in vivo lipids by a two-dimensional image, thereby allowing diagnosis of diseases due to accumulation of lipids. According to the present invention, provided are a medicine for detecting in vivo lipids, comprising one or more components such as oxLDL and lyso PC, as an effective component, selected from a sulfonic acid blue dye having a radical —SO3−, a homidium, Metanyl yellow and Lissamin fast yellow, and an angioscopic system for obtaining a fluorescent image, which comprises a mercury-xenon lamp light source, a quartz fiberscope wherein the light guide part has 100 to 200 fibers and the image guide part has 7000 to 9000 fibers, a rotational exciting filter, an emitting filter, and a high-sensitive digital camera for picking up the fluorescence as a two-dimensional color image.

Abstract translation: 本发明提供能够通过二维图像检测体内脂质的位置和扩散的药物和装置，从而能够诊断由于脂质的积累引起的疾病。

公开(公告)号：US20060189695A1

公开(公告)日：2006-08-24

申请号：US10561814

申请日：2003-06-25

Applicant: Yasumi Uchida ,  Yasuto Uchida ,  Haruko Uchida

Inventor： Yasumi Uchida ,  Yasuto Uchida ,  Haruko Uchida

IPC: A61K31/557

CPC classification number: A61K9/0014 ,  A61K9/0034 ,  A61K9/145 ,  A61K9/146 ,  A61K31/5575 ,  A61K38/40 ,  A61K47/06 ,  A61K47/10 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42

Abstract: The present invention provides a preventive or a remedy for penile erectile dysfunction, which promotes blood-flow in a penile sponge body over long time and thus induces erection while showing high safety without any adverse effect on a body as a whole, when externally administered to a penis. Use of a drug of the present invention enables to prevent or treat male penile erectile dysfunction and, at the same time, overcome a problem of female insertion impediment caused by increased resistance due to vaginal secretion disorder. Namely, a sexual life of patients (including aged persons) having coital dysfunction can be normalized and thus QOL can be improved.

Abstract translation: 本发明提供了阴茎勃起功能障碍的预防或补救措施，其可以长时间促进阴茎海绵体中的血液流动，从而诱导勃起，同时显示高安全性，而对整个身体没有任何不利影响，当外部给予 阴茎 使用本发明的药物能够预防或治疗男性阴茎勃起功能障碍，同时克服由阴道分泌障碍引起的阻力增加引起的女性插入障碍的问题。 也就是说，具有社会功能障碍的患者（包括老年人）的性生活可以被归一化，因此可以改善生活质量。

公开(公告)号：US20060122264A1

公开(公告)日：2006-06-08

申请号：US10559708

申请日：2003-06-09

Applicant: Yasumi Uchida ,  Haruko Uchida

Inventor： Yasumi Uchida ,  Haruko Uchida

IPC: A61K31/365

CPC classification number: A61L31/16 ,  A61K31/343 ,  A61K31/39 ,  A61L31/10 ,  A61L2300/442 ,  C07D327/04

Abstract: The present invention provides an inhibitor of the invasion of bone-marrow-derived vascular stem cells or inflammatory cells into blood vessel walls, a blood vessel restenosis inhibitor, and a preventive or therapeutic drug for angiitis or myocardiitis, each containing a phthalein dye compound as an active ingredient; and an instrument for treating blood vessels which is coated with a resin containing a phthalein dye compound or made of such a resin. Use of the drug of the present invention enables effective prevention of restenosis of a blood vessel after, for example, angioplasy. Moreover, it is possible to prevent the progress and disruption of a lesion of angiitis, myocarditis, or arterioscrelosis, for which no efficacious preventive or therapeutic method has been established so far, as well as microvascular ischemic diseases. By performing a medical treatment such as angioplasy using the instrument of the present invention for treating blood vessels, events of vascular restenosis can be effectively prevented.

Abstract translation: 本发明提供了将骨髓来源的血管干细胞或炎症细胞侵入血管壁的抑制剂，血管再狭窄抑制剂和用于血管炎或心肌炎的预防或治疗药物，每种含有酞菁染料化合物作为 活性成分; 以及用于治疗血管的器械，其中涂有含有酞菁染料化合物或由这种树脂制成的树脂。 使用本发明的药物能够有效地防止例如血管淤血后的血管再狭窄。 此外，可以防止迄今为止没有建立有效的预防或治疗方法以及微血管缺血性疾病的血管炎，心肌炎或动脉硬化性病变的进展和破坏。 通过使用本发明的用于治疗血管的器械进行诸如血管性皮炎的治疗，可以有效地防止血管再狭窄的事件。

公开(公告)号：US07025981B2

公开(公告)日：2006-04-11

申请号：US10237012

申请日：2002-09-09

Applicant: Yasumi Uchida ,  Haruko Uchida

Inventor： Yasumi Uchida ,  Haruko Uchida

IPC: A61F2/02

CPC classification number: A61L31/16 ,  A61L31/08 ,  A61L2300/416 ,  A61L2300/442 ,  A61L2300/606

Abstract: The present invention relates to a therapeutic tool for vascular diseases, which is coated with a dye-containing resin that comprises one or more biocompatible dyes selected from the group consisting of sulfonic acid azo dye, phthalein dye, triphenylmethane dye, phenantridium dye, acrydine dye, xanthene dye, phenothiazine dye and cyanine dye; a medical treatment by the use of the therapeutic tool for vascular diseases; and a method of preventing vascular restenosis caused mainly through inhibition of migration of vascular progenitor cells by administering the medical treatment to a subject.Since the present therapeutic tool for vascular diseases is capable of staying in vivo for a long term, a medical treatment such as angioplasty (coronary angioplasty, peripheral angioplasty, cerebral angioplasty, etc.) and blood vessel bypass (coronary bypass, peripheral bypass) by the use of the present tool can effectively inhibit the generation of blood vessel restenosis by inhibiting migration of vascular progenitor cells. Thus, the present tool is extremely useful in clinical situations.

公开(公告)号：US4727085A

公开(公告)日：1988-02-23

申请号：US706748

申请日：1985-02-28

Applicant: Masami Shiratsuchi ,  Kiyoshi Kawamura ,  Toshihiro Akashi ,  Hiroshi Ishihama ,  Yasumi Uchida

Inventor： Masami Shiratsuchi ,  Kiyoshi Kawamura ,  Toshihiro Akashi ,  Hiroshi Ishihama ,  Yasumi Uchida

IPC: A61K31/35 ,  C07D311/64

CPC classification number: A61K31/35 ,  C07D311/64

Abstract: A novel racemate K-351A composed of an optical isomer (2'S),(3S)K-351 [3,4-dihydro-8-(2'-hydroxy-3'-isopropylamino)propoxy-3-nitroxy-2H-1-benzopyran] and (2'R),(3R)K-351, a novel racemate K-351B composed of an optical isomer (2'R),(3S)K-351 and (2'S),(3R)K351 and an acid addition salt of these two novel racemates; a process for converting the two racemates to each other; and also to a pharmaceutical composition comprising each of the two racemates useful for the treatment of cardiovascular diseases.

Abstract translation: 由旋光异构体（2'S），（3S）K-351 [3,4-二氢-8-（2'-羟基-3'-异丙氨基）丙氧基-3-硝酰氧基-2H-1 （3S）K-351和（2'S），（3R）K351组成的新型外消旋体K-351B，（3R）K-351 和这两种新型外消旋体的酸加成盐; 将两种消旋体相互转化的过程; 并且还涉及包含用于治疗心血管疾病的两种外消旋体中的每一种的药物组合物。

公开(公告)号：US4448989A

公开(公告)日：1984-05-15

申请号：US451322

申请日：1982-12-20

Applicant: Masami Shiratsuchi ,  Hiroshi Ishihama ,  Yasumi Uchida

Inventor： Masami Shiratsuchi ,  Hiroshi Ishihama ,  Yasumi Uchida

IPC: A61K31/165 ,  A61P9/00 ,  C07C67/00 ,  C07C231/00 ,  C07C235/48 ,  C07C235/60 ,  C07D303/22 ,  C07C103/76 ,  C07C103/78

CPC classification number: C07D303/22

Abstract: A compound represented by the following formula ##STR1## wherein R represents a lower alkyl group having 2 to 6 carbon atoms, and n is an integer of from 1 to 5.

Abstract translation: 由下式表示的化合物＆lt; IMAGE＆gt;其中，R表示碳原子数2〜6的低级烷基，n为1〜5的整数。

公开(公告)号：US4737506A

公开(公告)日：1988-04-12

申请号：US851134

申请日：1986-04-07

Applicant: Noboru Shimizu ,  Hiroyuki Ishiwata ,  Tomio Ohta ,  Hiroshi Ishihama ,  Yasumi Uchida

Inventor： Noboru Shimizu ,  Hiroyuki Ishiwata ,  Tomio Ohta ,  Hiroshi Ishihama ,  Yasumi Uchida

IPC: C07D401/12 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/455 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D211/90 ,  C07D401/14

CPC classification number: C07D211/90

Abstract: This invention relates to a 1,4-dihydropyridine-3,5-dicarboxylate derivative represented by the following general formula (I): ##STR1## wherein R means an imidazolyl or pyridyl group, R.sub.1 denotes a hydrogen or halogen atom or a nitro or trifluoromethyl group, R.sub.2 is a lower alkyl group, X is CH or N, A means a lower alkylene group, ##STR2## B being a lower alkylene or O-lower alkylene group, ##STR3## R.sub.4 being a hydrogen atom or lower alkyl group, or ##STR4## m denotes a number of 1-3, and n stands for 1 or 2. The derivative has vasodilative effects, hyperkinemic effects, platelet aggregation inhibitory effects, thromboxane A.sub.2 formation inhibitory effects and so on, and are hence useful as a pharmaceutical product such as vasodilator, antihypertensive, antithrombotic agent, antiarteriosclerotic agent or the like.

Abstract translation: PCT No.PCT / JP85 / 00449 Sec。 一九八六年四月七日 102（e）日期1986年4月7日PCT提交1985年8月12日PCT公布。 公开号WO86 / 01206 PCT 日本特愿1986年2月27日。本发明涉及由以下通式（I）表示的1,4-二氢吡啶-3,5-二羧酸酯衍生物：其中R表示咪唑基或吡啶基，R1 表示氢或卤素原子或硝基或三氟甲基，R 2为低级烷基，X为CH或N，A表示低级亚烷基，B为低级亚烷基或O-低级亚烷基，IMA图 > R4是氢原子或低级烷基，或者表示1-3个数，n代表1或2.该衍生物具有血管扩张作用，超动力作用，血小板聚集抑制作用，血栓素A2形成抑制 效果等，因此可用作药物产品如血管扩张剂，抗高血压剂，抗血栓形成剂，抗动脉硬化剂等。

公开(公告)号：US4394382A

公开(公告)日：1983-07-19

申请号：US271927

申请日：1981-06-09

Applicant: Masami Shiratsuchi ,  Noboru Shimizu ,  Hiromichi Shigyo ,  Yoshinori Kyotani ,  Hisashi Kunieda ,  Kiyoshi Kawamura ,  Seiichi Sato ,  Toshihiro Akashi ,  Masahiko Nagakura ,  Naotoshi Sawada ,  Yasumi Uchida

Inventor： Masami Shiratsuchi ,  Noboru Shimizu ,  Hiromichi Shigyo ,  Yoshinori Kyotani ,  Hisashi Kunieda ,  Kiyoshi Kawamura ,  Seiichi Sato ,  Toshihiro Akashi ,  Masahiko Nagakura ,  Naotoshi Sawada ,  Yasumi Uchida

IPC: C07D311/04 ,  A61K31/353 ,  A61P9/02 ,  A61P9/04 ,  A61P21/02 ,  C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66 ,  A61K31/35

CPC classification number: C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66 ,  Y10S514/821

Abstract: A benzopyran compound represented by the following ##STR1## wherein A represents a direct bond or the bond --CH.sub.2 --O--,R.sub.1 represents a member selected from the group consisting of a C.sub.3 -C.sub.5 alkyl group, a hydroxy-(C.sub.3 -C.sub.5 alkyl) group, a lower alkylamino-lower alkyl group, a nitrato-(C.sub.3 -C.sub.5 alkyl) group and a phenyl-(C.sub.1 -C.sub.5) alkyl group, provided that the phenyl may be substituted by a lower alkoxy group, R.sub.2 represents a member selected from the group consisting of hydrogen, halogen, OH, NO.sub.2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group and acetyl group,R.sub.3 represents hydrogen or NO.sub.2,B represents a direct bond, a C.sub.1 -C.sub.7 alkylene group, a --O-lower alkylene group or a --CONH-lower alkylene group, andn represents 1 or 2;and an acid addition salt thereof and a pharmaceutical composition comprising aforesaid compound.

Abstract translation: 由下式（I）表示的苯并吡喃化合物，其中A表示直接键或键-CH2-O-，R1表示选自C3-C5烷基，羟基 - （C3 -C 5烷基）基，低级烷基氨基 - 低级烷基，硝基 - （C 3 -C 5烷基）基和苯基 - （C 1 -C 5）烷基，条件是苯基可以被低级烷氧基取代，R 2 表示选自氢，卤素，OH，NO 2，氨基甲酰基，低级烷基，低级烷氧基，低级亚烷基氧基和乙酰基的成员，R 3表示氢或NO 2，B表示直接键 ，C 1 -C 7亚烷基，-O-低级亚烷基或-CONH-低级亚烷基，n表示1或2; 及其酸加成盐和包含上述化合物的药物组合物。

公开(公告)号：US5576324A

公开(公告)日：1996-11-19

申请号：US325270

申请日：1994-10-27

Applicant: Yoshinori Kyotani ,  Tadaaki Ohgiya ,  Tsutomu Toma ,  Yuji Kurihara ,  Takahiro Kitamura ,  Takashi Yamaguchi ,  Kazuhiro Onogi ,  Seiichi Sato ,  Hiromichi Shigyo ,  Tomio Ohta ,  Mitsuo Kawada ,  Yasumi Uchida

Inventor： Yoshinori Kyotani ,  Tadaaki Ohgiya ,  Tsutomu Toma ,  Yuji Kurihara ,  Takahiro Kitamura ,  Takashi Yamaguchi ,  Kazuhiro Onogi ,  Seiichi Sato ,  Hiromichi Shigyo ,  Tomio Ohta ,  Mitsuo Kawada ,  Yasumi Uchida

IPC: C07D491/04 ,  C07D491/048 ,  C07D491/056 ,  A61K31/44

CPC classification number: C07D491/04

Abstract: A quinoline derivative represented by general formula (1), a medicinally acceptable salt thereof, and a remedy for cardiac diseases containing the same: ##STR1## [wherein ring A represents a furan, dihydrofuran or dioxolane ring, and R.sup.1 represents an aminoalkyl group].The compound (1) has a positively inotropic effect on myocardia and an antiarrhythmic effect, and can dilate blood vessels without extremely increasing the heart rate. Therefore, a remedy for cardiac diseases containing the same as the active ingredient is remarkably useful for treating cardiac insufficiency, arrhythmia, and so forth.

Abstract translation: PCT No.PCT / JP93 / 00566 Sec。 371日期：1994年10月27日 102（e）日期1994年10月27日PCT提交1993年4月28日PCT公布。 公开号WO93 / 22317 日本特公昭日1993年11月11日由通式（1）表示的喹啉衍生物及其药学上可接受的盐以及含有该喹啉衍生物的心脏病的药物：其中环A表示呋喃，二氢呋喃或二氧戊环 ，R1表示氨基烷基]。 化合物（1）对心肌具有正性变力作用，具有抗心律失常作用，能够扩张血管而不会极大地提高心率。 因此，含有与活性成分相同的心脏病的治疗对于治疗心功能不全，心律失常等是非常有用的。

公开(公告)号：US4678803A

公开(公告)日：1987-07-07

申请号：US716462

申请日：1985-03-27

Applicant: Masami Shiratsuchi ,  Kiyoshi Kawamura ,  Toshihiro Akashi ,  Hiroshi Ishihama ,  Yasumi Uchida

Inventor： Masami Shiratsuchi ,  Kiyoshi Kawamura ,  Toshihiro Akashi ,  Hiroshi Ishihama ,  Yasumi Uchida

IPC: A61K31/35 ,  A61K31/352 ,  A61P9/08 ,  A61P9/12 ,  A61P25/02 ,  C07D303/16 ,  C07D311/64 ,  C07D407/12

CPC classification number: C07D407/12 ,  C07D303/16 ,  C07D311/64

Abstract: An optical isomer selected from the group consisting of (2'R),(3R)-3,4-dihydro-8-(2'-hydroxy-3'-isopropylamino)propoxy-3-nitroxy-2H-1-benzopyran, (2'S),(3R)-3,4-dihydro-8-(2'-hydroxy-3'-isopropylamino)propoxy-3-nitroxy-2H-1-benzopyran and acid addition salts of these isomers, process for producing these isomers and a pharmaceutical composition thereof useful for the treatment of cardiovascular diseases.

Abstract translation: 选自（2'R），（3R）-3,4-二氢-8-（2'-羟基-3'-异丙基氨基）丙氧基-3-硝基苯基-2H-1-苯并吡喃的旋光异构体 ，（2'S），（3R）-3,4-二氢-8-（2'-羟基-3'-异丙氨基）丙氧基-3-硝基xy-2H-1-苯并吡喃和这些异构体的酸加成盐，方法 制备这些异构体及其用于治疗心血管疾病的药物组合物。