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1.发明公开公开(公告)号：US20230398128A1
公开(公告)日：2023-12-14
申请号：US18201498
申请日：2023-05-24
发明人： Om DHINGRA , James S. BERNSTEIN
CPC分类号： A61K31/568 , A61K47/28 , A61K47/44 , A61K47/34 , A61P9/02 , A61K9/0053
摘要： The present invention features new testosterone undecanoate (TU) dosing regimens, e.g., for testosterone replacement therapy. The TU may be formulated with phytosterols or phytosterol esters.
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公开(公告)号：US11707502B2
公开(公告)日：2023-07-25
申请号：US17707497
申请日：2022-03-29
申请人： MANKIND PHARMA LTD.
发明人： Saurabh Kumar , Ankush Gupta , Hanumant Gambhire , Raghuveera H. G , P. V. S Narasimham , Anil Kumar
IPC分类号： A61K38/095 , A61P9/02 , A61K47/12 , A61K47/18
CPC分类号： A61K38/095 , A61K47/12 , A61K47/183 , A61P9/02
摘要： The present invention relates to a stable pharmaceutical composition comprising vasopressin or pharmaceutically acceptable salts thereof. The present invention further provides a method of increasing blood pressure in adults with vasodilatory shock by administering said pharmaceutical composition of vasopressin or pharmaceutically acceptable salts thereof.
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公开(公告)号：US20230218592A1
公开(公告)日：2023-07-13
申请号：US17996575
申请日：2021-04-20
发明人： Steven BURKE , Michael RABINOWITZ
IPC分类号： A61K31/4418 , A61P11/00 , A61P31/14 , A61P13/12 , A61P1/16 , A61P25/00 , A61P9/02 , A61K45/06
CPC分类号： A61K31/4418 , A61P11/00 , A61P31/14 , A61P13/12 , A61P1/16 , A61P25/00 , A61P9/02 , A61K45/06
摘要： Disclosed herein are new therapeutic methods comprising administering compounds that can stabilize HIF and inhibit HIF prolyl hydroxylase (HIF-PH). In particular, methods described herein can be useful for treating/preventing a disease or condition in patients in need thereof, such as a patient having a viral infection such as a respiratory and/or pulmonary viral infection (e.g., an infection such as COVID-19 or a coronavirus infection). Methods described herein can also be useful for treating/preventing organ injury (e.g. organ injury that occurs concurrently or as a result of an infection). For example, methods described herein can be useful for treating or preventing acute lung injury, acute respiratory distress syndrome (ARDS), cardiovascular injury, injury to the liver, kidney diseases, and/or multi-organ failure.
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公开(公告)号：US11590107B2
公开(公告)日：2023-02-28
申请号：US17079263
申请日：2020-10-23
发明人： Anthony P. Ford
IPC分类号： A61K31/4164 , A61P9/02
摘要： In various aspects and embodiments provided are compositions and methods for a disease or disorder in a patient such as a disease or disorder that affects the brain in a patient and treating such patient.
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公开(公告)号：US20220409700A1
公开(公告)日：2022-12-29
申请号：US17752664
申请日：2022-05-24
摘要： The present invention relates a pharmaceutical composition comprising a controlled-release CNP agonist which reduces CNP agonist-associated side-effects, the use of such controlled-release CNP agonist and to methods of treatment.
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公开(公告)号：US20220226423A1
公开(公告)日：2022-07-21
申请号：US17707497
申请日：2022-03-29
申请人： MANKIND PHARMA LTD.
发明人： Saurabh KUMAR , Ankush GUPTA , Hanumant GAMBHIRE , Raghuveera H.G , P. V. S NARASIMHAM , Anil KUMAR
IPC分类号： A61K38/095 , A61P9/02 , A61K47/12 , A61K47/18
摘要： The present invention relates to a stable pharmaceutical composition comprising vasopressin or pharmaceutically acceptable salts thereof. The present invention further provides a method of increasing blood pressure in adults with vasodilatory shock by administering said pharmaceutical composition of vasopressin or pharmaceutically acceptable salts thereof.
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公开(公告)号：US11306148B2
公开(公告)日：2022-04-19
申请号：US16657000
申请日：2019-10-18
发明人： Michael Dunn , Jia Su , Jason Mastaitis , Jesper Gromada , Lori Morton
摘要： The present invention provides monoclonal antibodies that bind to the natriuretic peptide receptor 1 (NPR1) protein, and methods of use thereof. In various embodiments of the invention, the antibodies are fully human antibodies that bind to NPR1. In some embodiments, the antibodies of the invention are useful for activating NPR1 activity, thus providing a means of treating or preventing a disease, disorder or condition associated with NPR1 in humans.
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公开(公告)号：US20200230079A1
公开(公告)日：2020-07-23
申请号：US16839450
申请日：2020-04-03
申请人： Nevakar Inc.
IPC分类号： A61K31/137 , A61K47/18 , A61K47/12 , A61K9/00 , A61P9/02
摘要： The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-norepinephrine and exhibit less than 5% degradation of total norepinephrine.
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公开(公告)号：US10646458B2
公开(公告)日：2020-05-12
申请号：US16239465
申请日：2019-01-03
申请人： Nevakar, Inc.
IPC分类号： A61K31/137 , A61K9/00 , A61P9/02 , A61K47/12 , A61K47/18
摘要： The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-norepinephrine and exhibit less than 5% degradation of total norepinephrine.
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公开(公告)号：US20190240284A1
公开(公告)日：2019-08-08
申请号：US16343232
申请日：2017-10-20
申请人： Chiasma, Inc.
发明人： Gary Patou
IPC分类号： A61K38/095 , A61K31/573 , A61K45/06 , A61K9/28 , A61K9/48 , A61P1/16 , A61P9/02 , A61P9/12
CPC分类号： A61K38/095 , A61K9/28 , A61K9/4891 , A61K31/573 , A61K45/06 , A61P1/16 , A61P9/02 , A61P9/12
摘要： Methods are disclosed of treating or preventing hypotension (e.g., neurogenic orthostatic hypotension or postprandial hypotension) or portal hypertension (e.g., bleeding esophageal varices associated with portal hypertension) or ascites (e.g., ascites associated with liver cirrhosis), by oral administration to affected subjects of compositions comprising a therapeutically effective amount of terlipressin or a pharmaceutically acceptable salt thereof.
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