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公开(公告)号：US20230114648A1
公开(公告)日：2023-04-13
申请号：US18073632
申请日：2022-12-02
发明人： Jess Dreher Reed , Dhanansayan Shanmuganayagam , Christian Gerald Krueger , Kenneth Allan Kudsk , Joseph Francis Pierre , Aaron F. Heneghan , Rodrigo P. Feliciano
IPC分类号： A61K31/353 , A61K9/00 , A23L33/00 , A23L33/10 , A23L33/17 , A23L33/115
摘要： Tannin-containing compositions and methods of using same to enhance or maintain immune function during simplified nutrition feeding. Pharmaceutical compositions, including enteral nutrition compositions, are provided. The compositions comprise such tannins as proanthocyanidins and/or hydrolysable tannins. Administering the tannins to the gastrointestinal tract of a subject receiving simplified nutrition, such as with enteral nutrition therapy or parenteral nutrition therapy, attenuates or prevents deleterious effects on the gastrointestinal immune system that would otherwise occur with the simplified nutrition.
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公开(公告)号：US10104888B2
公开(公告)日：2018-10-23
申请号：US15380754
申请日：2016-12-15
IPC分类号： A61K47/36 , A01N43/16 , A61K9/00 , A61K9/06 , A61K9/19 , A61K9/20 , A61K9/51 , A61K9/70 , A61K31/715 , A61K39/39 , A61K45/06 , A61K49/22 , A61L29/08 , A61L31/10 , A61K31/722 , A61K31/353 , A01N25/16 , A01N43/24 , A61K9/12 , A61K9/127 , A61K31/351 , A61K31/366 , A61K39/00 , A61K47/55 , A61F13/00 , C08H7/00
摘要： The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and/or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.
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公开(公告)号：US20170142967A1
公开(公告)日：2017-05-25
申请号：US15380754
申请日：2016-12-15
IPC分类号： A01N43/16 , A61K9/20 , A61K9/51 , A61K9/00 , A61K9/12 , A61K9/06 , A61K39/00 , A61K39/39 , A61K31/722 , A61K31/353 , A61K31/366 , A61K31/351 , A01N43/24 , A01N25/16 , A61K9/127
CPC分类号： A01N43/16 , A01N25/16 , A01N43/24 , A23V2250/21166 , A61F2013/00523 , A61F2013/00676 , A61K9/0014 , A61K9/0019 , A61K9/008 , A61K9/06 , A61K9/12 , A61K9/122 , A61K9/1273 , A61K9/19 , A61K9/2013 , A61K9/2054 , A61K9/5123 , A61K9/5161 , A61K9/7007 , A61K31/351 , A61K31/353 , A61K31/366 , A61K31/715 , A61K31/722 , A61K39/0005 , A61K39/39 , A61K45/06 , A61K47/36 , A61K47/55 , A61K49/227 , A61K2039/542 , A61K2039/55583 , A61L29/085 , A61L31/10 , C08H6/00 , A01N25/28 , A01N2300/00 , A61K2300/00 , C08L5/08
摘要： The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and/or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.
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公开(公告)号：US11306128B2
公开(公告)日：2022-04-19
申请号：US16723551
申请日：2019-12-20
发明人： Jess Dreher Reed , Sergio Madrigal-Carballo , Michael Allen Polewski , Christian Gerald Krueger , Emilia Alfaro-Viquez
摘要： Methods of purifying mucin, purified mucin, and products comprising the purified mucin. The methods include combining a mucin-containing substance with water and one or more purification agents to form a purification mixture, incubating the purification mixture for a time sufficient to form a mucin precipitate in a liquid phase, and separating the mucin precipitate from the liquid phase. The purification agents include one or more of a surfactant, a chelating agent, and a protic solvent. The mucin purified from the methods can be used alone or in combination with a biopolymer such as a tannin and chitosan and can be used to generate materials in the form of a gel, a foam, a film, or a powder.
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公开(公告)号：US09545423B2
公开(公告)日：2017-01-17
申请号：US14139081
申请日：2013-12-23
IPC分类号： A61K47/36 , A61K31/722 , A01N43/16 , A61K9/00 , A61K9/06 , A61K9/19 , A61K9/51 , A61K9/70 , A61K31/715 , A61K39/39 , A61K45/06 , A61K49/22 , A61L29/08 , A61L31/10 , A61K31/353 , A61K9/20 , A61K39/00 , A61F13/00 , C08H7/00
CPC分类号： A01N43/16 , A01N25/16 , A01N43/24 , A23V2250/21166 , A61F2013/00523 , A61F2013/00676 , A61K9/0014 , A61K9/0019 , A61K9/008 , A61K9/06 , A61K9/12 , A61K9/122 , A61K9/1273 , A61K9/19 , A61K9/2013 , A61K9/2054 , A61K9/5123 , A61K9/5161 , A61K9/7007 , A61K31/351 , A61K31/353 , A61K31/366 , A61K31/715 , A61K31/722 , A61K39/0005 , A61K39/39 , A61K45/06 , A61K47/36 , A61K47/55 , A61K49/227 , A61K2039/542 , A61K2039/55583 , A61L29/085 , A61L31/10 , C08H6/00 , A01N25/28 , A01N2300/00 , A61K2300/00 , C08L5/08
摘要： The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and/or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.
摘要翻译： 本发明提供包含壳聚糖和单宁的基质的组合物，其中壳聚糖与单宁静电键合以形成壳聚糖 - 单宁复合材料。 壳聚糖可以部分或全部脱乙酰化，单宁可以是单体或低聚原花色素或可水解的单宁。 壳聚糖 - 单宁复合材料可以是纳米颗粒，水凝胶膜，生物泡沫或生物凝胶，或壳聚糖 - 单宁复合材料可以包覆脂质体。 复合材料可用于药物递送，用于抗菌和/或抗真菌应用，用于组织工程应用，用于伤口愈合应用，或者它们可以用作疫苗接种的辅助剂，包括口服疫苗接种。 本发明还提供了制备复合材料及其各种形式的方法。
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公开(公告)号：US20140200266A1
公开(公告)日：2014-07-17
申请号：US14152267
申请日：2014-01-10
发明人： Jess Dreher Reed , Dhanansayan Shanmuganayagam , Christian Gerald Krueger , Kenneth Allan Kudsk , Joseph Francis Pierre , Aaron F. Heneghan , Rodrigo P. Feliciano
IPC分类号： A61K31/353
CPC分类号： A61K31/353 , A23L33/10 , A23L33/115 , A23L33/17 , A23L33/40 , A23V2002/00 , A61K9/0029
摘要： Tannin-containing compositions and methods of using same to enhance or maintain immune function during simplified nutrition feeding. Pharmaceutical compositions, including enteral nutrition compositions, are provided. The compositions comprise such tannins as proanthocyanidins and/or hydrolysable tannins. Administering the tannins to the gastrointestinal tract of a subject receiving simplified nutrition, such as with enteral nutrition therapy or parenteral nutrition therapy, attenuates or prevents deleterious effects on the gastrointestinal immune system that would otherwise occur with the simplified nutrition.
摘要翻译： 含单宁的组合物和使用它们的方法在简化的营养喂养期间增强或维持免疫功能。 提供药物组合物，包括肠内营养组合物。 组合物包含这样的单宁，如原花青素和/或可水解的单宁。 将单宁管理到接受简化营养的受试者的胃肠道，例如用肠内营养治疗或肠外营养治疗，可以减轻或预防对于简化营养时会出现的对胃肠道免疫系统的有害影响。
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公开(公告)号：US20210085641A1
公开(公告)日：2021-03-25
申请号：US17111948
申请日：2020-12-04
发明人： Jess Dreher Reed , Dhanansayan Shanmuganayagam , Christian Gerald Krueger , Kenneth Allan Kudsk , Joseph Francis Pierre , Aaron F. Heneghan , Rodrigo P. Feliciano
IPC分类号： A61K31/353 , A61K9/00 , A23L33/00 , A23L33/10 , A23L33/17 , A23L33/115
摘要： Tannin-containing compositions and methods of using same to enhance or maintain immune function during simplified nutrition feeding. Pharmaceutical compositions, including enteral nutrition compositions, are provided. The compositions comprise such tannins as proanthocyanidins and/or hydrolysable tannins. Administering the tannins to the gastrointestinal tract of a subject receiving simplified nutrition, such as with enteral nutrition therapy or parenteral nutrition therapy, attenuates or prevents deleterious effects on the gastrointestinal immune system that would otherwise occur with the simplified nutrition.
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公开(公告)号：US10881635B2
公开(公告)日：2021-01-05
申请号：US16102844
申请日：2018-08-14
发明人： Jess Dreher Reed , Dhanansayan Shanmuganayagam , Christian Gerald Krueger , Kenneth Allan Kudsk , Joseph Francis Pierre , Aaron F. Heneghan , Rodrigo P. Feliciano
IPC分类号： A61K31/353 , A61K9/00 , A23L33/00 , A23L33/10 , A23L33/17 , A23L33/115
摘要： Tannin-containing compositions and methods of using same to enhance or maintain immune function during simplified nutrition feeding. Pharmaceutical compositions, including enteral nutrition compositions, are provided. The compositions comprise such tannins as proanthocyanidins and/or hydrolysable tannins. Administering the tannins to the gastrointestinal tract of a subject receiving simplified nutrition, such as with enteral nutrition therapy or parenteral nutrition therapy, attenuates or prevents deleterious effects on the gastrointestinal immune system that would otherwise occur with the simplified nutrition.
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公开(公告)号：US20170056369A1
公开(公告)日：2017-03-02
申请号：US15347204
申请日：2016-11-09
发明人： Jess Dreher Reed , Dhanansayan Shanmuganayagam , Christian Gerald Krueger , Kenneth Allan Kudsk , Joseph Francis Pierre , Aaron F. Heneghan , Rodrigo P. Feliciano
IPC分类号： A61K31/353 , A23L33/10 , A23L33/17 , A23L33/115 , A61K9/00 , A23L33/00
CPC分类号： A61K31/353 , A23L33/10 , A23L33/115 , A23L33/17 , A23L33/40 , A23V2002/00 , A61K9/0029
摘要： Tannin-containing compositions and methods of using same to enhance or maintain immune function during simplified nutrition feeding. Pharmaceutical compositions, including enteral nutrition compositions, are provided. The compositions comprise such tannins as proanthocyanidins and/or hydrolysable tannins. Administering the tannins to the gastrointestinal tract of a subject receiving simplified nutrition, such as with enteral nutrition therapy or parenteral nutrition therapy, attenuates or prevents deleterious effects on the gastrointestinal immune system that would otherwise occur with the simplified nutrition.
摘要翻译： 含单宁的组合物和使用它们的方法在简化的营养喂养期间增强或维持免疫功能。 提供药物组合物，包括肠内营养组合物。 组合物包含这样的单宁，如原花青素和/或可水解的单宁。 将单宁管理到接受简化营养的受试者的胃肠道，例如用肠内营养治疗或肠外营养治疗，可以减轻或预防对于简化营养时会出现的对胃肠道免疫系统的有害影响。
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公开(公告)号：US11559511B2
公开(公告)日：2023-01-24
申请号：US17111948
申请日：2020-12-04
发明人： Jess Dreher Reed , Dhanansayan Shanmuganayagam , Christian Gerald Krueger , Kenneth Allan Kudsk , Joseph Francis Pierre , Aaron F. Heneghan , Rodrigo P. Feliciano
IPC分类号： A61K31/353 , A61K9/00 , A23L33/00 , A23L33/10 , A23L33/17 , A23L33/115
摘要： Tannin-containing compositions and methods of using same to enhance or maintain immune function during simplified nutrition feeding. Pharmaceutical compositions, including enteral nutrition compositions, are provided. The compositions comprise such tannins as proanthocyanidins and/or hydrolysable tannins. Administering the tannins to the gastrointestinal tract of a subject receiving simplified nutrition, such as with enteral nutrition therapy or parenteral nutrition therapy, attenuates or prevents deleterious effects on the gastrointestinal immune system that would otherwise occur with the simplified nutrition.
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