公开(公告)号：US10060560B2

公开(公告)日：2018-08-28

申请号：US14414138

申请日：2013-06-25

申请人： Waters Technologies Corporation

发明人： Jonathan L. Belanger ,  Sylvain Cormier ,  Steven D. Trudeau ,  Paul Keenan ,  Daniel J. McCormick

IPC分类号： F16L15/04 ,  F16J15/08 ,  F16J15/10 ,  G01N30/60 ,  B01D15/10 ,  B01D15/22 ,  B01D15/40 ,  F16L19/02

CPC分类号： F16L15/04 ,  B01D15/10 ,  B01D15/22 ,  B01D15/40 ,  F16J15/0806 ,  F16J15/102 ,  F16L19/0212 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026

摘要： Described is a mobile phase fitting having reduced corrosion and erosion. The fitting includes a coupling body, compression screw, compression member and gasket. The coupling body has a threaded bore at one end, a tapered cavity, a narrow bore and a fluid channel. The compression screw has an axial bore to receive a tube and a threaded outer surface in engagement with the threaded bore of the coupling body. The compression member is disposed in the tapered cavity and has an axial opening to pass the tube and a tapered surface to engage a surface of the tapered cavity. The gasket is disposed in the narrow bore and has one surface in contact with the first internal surface and has a parallel surface to receive an end face of the tube. Mobile phase flows along a path that includes the tube, an opening in the gasket and the fluid channel.

公开(公告)号：US20180202888A1

公开(公告)日：2018-07-19

申请号：US15872755

申请日：2018-01-16

申请人： Waters Technologies Corporation

发明人： Abhijit Tarafder ,  Moon Chul Jung ,  Jonathan L. Belanger ,  Xiangjin Song ,  Wade P. Leveille ,  Darryl W. Brousmiche

IPC分类号： G01M3/20 ,  G01N30/34 ,  G01N30/02

摘要： Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. A coating is disposed to conform to at least one component of a chromatography system, such as a fitting or a section of tubing. The coating is made of or contains a responsive material that can undergo a detectable change when exposed to a chromatographic fluid or mobile phase. The change of the responsive material can indicate the presence of the fluid or mobile phase, a change in at least one physical property of the coating to prevent passage of the fluid or mobile phase, or a combination thereof.

公开(公告)号：US20220357305A1

公开(公告)日：2022-11-10

申请号：US17864944

申请日：2022-07-14

申请人： Waters Technologies Corporation

发明人： Peter Kirby ,  Marcos O. Peroza ,  Steven D. Trudeau ,  Ryan M. Hill ,  Raymond P. Fisk ,  Jonathan L. Belanger ,  Wade P. Leveille

IPC分类号： G01N30/60 ,  F16L19/00 ,  B01D15/10 ,  G01N30/02 ,  G01N30/30

摘要： A thermal module for pre-heating liquid flowing into a liquid chromatography column, includes a trough compartment with two ends, one of the two ends having an electrical socket, a first fluidic assembly, a second fluidic assembly, and a clamp assembly. The clamp assembly includes a rail configured to receive the first fluidic assembly. The clamp assembly includes a carriage slidably mounted to the rail and configured to receive the second fluidic assembly. The carriage is operable to establish a first fluid tight seal between the first fluidic assembly and a chromatography column received within the clamp assembly, and to establish a second fluid tight seal between the second fluidic assembly and the chromatography column. The clamp assembly is disposed within the trough compartment, and the first fluidic assembly is plugged into the electrical socket at the one end of the trough compartment.

公开(公告)号：US20210339166A1

公开(公告)日：2021-11-04

申请号：US17241480

申请日：2021-04-27

申请人： Waters Technologies Corporation

发明人： Jonathan L. Belanger ,  Wade P. Leveille ,  Michael O. Fogwill ,  Joseph D. Michienzi ,  Jeffrey Musacchio

IPC分类号： B01D15/22 ,  F16J15/34

摘要： Described are apparatuses, devices, and systems implementing seals for separation devices. An apparatus for a separation device may include an end nut shaped to be positioned on one of an inlet side and an outlet side of the separation device. The end nut may be further shaped to mate with a connecting fitting. The apparatus may further include a face seal having a device side and a fitting side. The face seal may be positioned, at least in part, in the end nut on the device side of the face seal. The face seal may be positioned to interface with the connecting fitting on the fitting side of the face seal upon the end nut being mated with the connecting fitting. The apparatus may also include a face seal bore of the face seal being axially alignable with at least one of an inlet and an outlet of the separation device.

公开(公告)号：US20180335170A1

公开(公告)日：2018-11-22

申请号：US16049483

申请日：2018-07-30

申请人： Waters Technologies Corporation

发明人： Jonathan L. Belanger ,  Sylvain Cormier ,  Steven D. Trudeau ,  Paul Keenan ,  Daniel J. McCormick

IPC分类号： F16L15/04 ,  G01N30/60 ,  F16L19/02 ,  B01D15/10 ,  F16J15/08 ,  B01D15/40 ,  B01D15/22 ,  F16J15/10

CPC分类号： F16L15/04 ,  B01D15/10 ,  B01D15/22 ,  B01D15/40 ,  F16J15/0806 ,  F16J15/102 ,  F16L19/0212 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026

摘要： Described is a mobile phase fitting having reduced corrosion and erosion. The fitting includes a coupling body, compression screw, compression member and gasket. The coupling body has a threaded bore at one end, a tapered cavity, a narrow bore and a fluid channel. The compression screw has an axial bore to receive a tube and a threaded outer surface in engagement with the threaded bore of the coupling body. The compression member is disposed in the tapered cavity and has an axial opening to pass the tube and a tapered surface to engage a surface of the tapered cavity. The gasket is disposed in the narrow bore and has one surface in contact with the first internal surface and has a parallel surface to receive an end face of the tube. Mobile phase flows along a path that includes the tube, an opening in the gasket and the fluid channel.

公开(公告)号：US11986751B2

公开(公告)日：2024-05-21

申请号：US17241480

申请日：2021-04-27

申请人： Waters Technologies Corporation

发明人： Jonathan L. Belanger ,  Wade P. Leveille, Sr. ,  Michael O. Fogwill ,  Joseph D. Michienzi ,  Jeffrey Musacchio

IPC分类号： B01D15/22 ,  B01D15/10 ,  F16J15/34 ,  G01N30/60

CPC分类号： B01D15/22 ,  B01D15/10 ,  F16J15/34 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026

摘要： Described are apparatuses, devices, and systems implementing seals for separation devices. An apparatus for a separation device may include an end nut shaped to be positioned on one of an inlet side and an outlet side of the separation device. The end nut may be further shaped to mate with a connecting fitting. The apparatus may further include a face seal having a device side and a fitting side. The face seal may be positioned, at least in part, in the end nut on the device side of the face seal. The face seal may be positioned to interface with the connecting fitting on the fitting side of the face seal upon the end nut being mated with the connecting fitting. The apparatus may also include a face seal bore of the face seal being axially alignable with at least one of an inlet and an outlet of the separation device.

公开(公告)号：US11511213B2

公开(公告)日：2022-11-29

申请号：US15752121

申请日：2016-08-12

申请人： Waters Technologies Corporation

发明人： Jonathan L. Belanger ,  Hua Yang ,  Edouard S. P. Bouvier ,  Mathew DeLano ,  Raymond P. Fisk ,  Hillary B. Hewitson ,  Wade P. Leveille ,  Kevin Daniel Wyndham

IPC分类号： B01D15/22 ,  G01N30/60 ,  B01D53/02 ,  C12M1/40 ,  C12M1/00 ,  B01L3/00 ,  G01N30/72 ,  G01N30/88

摘要： Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.

公开(公告)号：US20190086371A1

公开(公告)日：2019-03-21

申请号：US16133089

申请日：2018-09-17

申请人： Waters Technologies Corporation

发明人： Matthew A. Lauber ,  Mathew H. DeLano ,  Scott A. McCall ,  Jonathan L. Belanger ,  Theodore A. Dourdeville ,  Kerri M. Smith ,  Paul D. Rainville ,  Dimple D. Shah ,  Stephen J. Shiner ,  Catalin Doneanu ,  Michael Donegan

IPC分类号： G01N30/56 ,  G01N30/60 ,  G01N30/72 ,  C23C14/24 ,  C23C14/12 ,  C23C14/04

摘要： A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20-, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.

公开(公告)号：US20180236379A1

公开(公告)日：2018-08-23

申请号：US15752121

申请日：2016-08-12

申请人： Waters Technologies Corporation

发明人： Jonathan L. Belanger ,  Hua Yang ,  Edouard S.P. Bouvier ,  Mathew DeLano ,  Raymond P. Fisk ,  Hillary B. Hewitson ,  Wade P. Leveille ,  Kevin Daniel Wyndham

IPC分类号： B01D15/22 ,  G01N30/60 ,  C12M1/40 ,  C12M1/00

CPC分类号： B01D15/22 ,  B01D53/02 ,  B01D53/025 ,  B01D2253/1122 ,  B01L3/502753 ,  C12M21/18 ,  C12M23/20 ,  G01N30/6052 ,  G01N30/6073 ,  G01N30/6095 ,  G01N30/7266 ,  G01N2030/8831

摘要： Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.

公开(公告)号：US20180207549A1

公开(公告)日：2018-07-26

申请号：US15873280

申请日：2018-01-17

申请人： Waters Technologies Corporation

发明人： Xiangjin Song ,  James P. Murphy ,  Keith Fadgen ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Jonathan L. Belanger ,  Moon Chul Jung ,  Abhijit Tarafder

IPC分类号： B01D15/14 ,  B65D1/02 ,  B65D23/14

CPC分类号： B01D15/14 ,  B01L3/545 ,  B01L9/00 ,  B01L2300/021 ,  B65D1/0223 ,  B65D23/14 ,  B65D2501/0081 ,  G01N30/26 ,  G01N30/80 ,  G01N35/00732

摘要： Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection. Designated solvent containers and exclusively designated solvent containers provide solvents for use by chromatography systems. Control over solvent supply is achieved by requiring matched container shape and container receiving position shape within the tray, and additionally or alternatively, through solvent container coding readable by the solvent tray and chromatography system which provide information about the solvent container to the chromatography system.