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公开(公告)号：US20230236145A1
公开(公告)日：2023-07-27
申请号：US18011024
申请日：2021-06-18
IPC分类号： G01N27/327 , G01N27/48
CPC分类号： G01N27/3274 , G01N27/3273 , G01N27/3272 , G01N27/48 , G01N33/48714
摘要： A computer-implemented method for interpreting an electrochemical response, comprises the steps of: (a) providing an electrochemical response that is baseline-corrected; (b) identifying in the electrochemical response one or more peaks that exceed a predetermined height threshold and a predetermined prominence threshold, each identified peak having a peak position; (c) providing a predetermined peak position range for each of a plurality of analytes; and (d) attributing one or more of the analytes to the peaks identified in step b, by, for each peak, associating the peak with an analyte when the peak position falls within the predetermined peak position range for the analyte.
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公开(公告)号：US20200309799A1
公开(公告)日：2020-10-01
申请号：US16756029
申请日：2018-10-15
摘要： A method for determining a narcotic in a mixture comprising at least one interferant. The method comprises: (a) determining a voltage at which, in absence of the interferant, a voltammetric signal of the narcotic can be detected; (b) contacting an electrode with the mixture comprising the at least one interferant and potentially comprising the narcotic; (c) applying a pretreatment potential to the electrode for a duration of at least 5 seconds, the pretreatment potential measuring between −0.4 V and −2 V versus Ag/AgCl; (d) measuring a voltammetric response of the mixture, the measurement comprising at least the determined voltage; and (e) determining whether the narcotic is present in the mixture by analyzing whether the voltammetric signal of the narcotic, resolved from a voltammetric signal of the interferant, can be detected in the measured voltammetric response.
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公开(公告)号：US20170122900A1
公开(公告)日：2017-05-04
申请号：US15318530
申请日：2015-06-14
发明人： Karolien DE WAEL , Luc NAGELS , Guido VAN CAMP
IPC分类号： G01N27/416 , G01N33/94
CPC分类号： G01N27/4161 , G01N33/53 , G01N33/946
摘要： The present invention relates to a method and system for obtaining an interaction property between a molecule or biomolecule or particle or bioparticle or nano- or microparticle on the one hand and a target particle on the other hand. The method comprises obtaining potentiometric titration results for a potentiometric measurement during titration of a solution with a titrant, said solution being a solution of one of a ligand of the target particle or said molecule or biomolecule or particle or bioparticle or nano- or microparticle. Said titrant comprises the other of said target particle ligand or said molecule or biomolecule or particle or bioparticle or nano- or microparticle. The method also comprises deriving based on said potentiometric titration results an interaction property between said molecule or biomolecule or particle or bioparticle or nano- or microparticle and said target particle.
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4.发明申请公开(公告)号：US20140318985A1
公开(公告)日：2014-10-30
申请号：US14254542
申请日：2014-04-16
发明人： Karolien DE WAEL , Lucien Nagels , Guido Van Camp
IPC分类号： G01N27/333
CPC分类号： G01N27/3335 , G01N27/327 , G01N27/40 , G01N33/54353
摘要： A coated-wire potentiometric sensor comprising an electronically conducting substrate electrode coated with an ionically conductive sensing layer and an outermost surface consisting of or comprising in and/or on a first molecular species which is capable of reversibly adsorbing a second molecular species and a method for measuring the affinity between a first molecular species and a second molecular species comprising the steps of: providing a potentiometric sensor of the coated-wire type having an outermost surface; adapting said outermost surface so that consists of or comprises said first molecular species; placing said sensor in a system for the recording of sensorgrams; recording a sensorgram of the adsorption of a second molecular species on said first molecular species of or comprised in and/or on said adapted outermost surface.
摘要翻译： 一种涂覆线电位传感器，其包括涂覆有离子导电感测层的电子导电基底电极和由能够可逆地吸附第二分子物质的第一分子物质组成或包含在其中和/或之上的最外表面，以及用于 测量第一分子物质和第二分子物质之间的亲和力，包括以下步骤：提供具有最外表面的涂覆线型电位计传感器; 使所述最外表面适应成由或包含所述第一分子种类; 将所述传感器放置在用于记录传感图的系统中; 记录第二分子物质在所述第一分子种类上或包含在所述适配的最外表面中和/或上的吸附的传感图。
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公开(公告)号：US20240219339A1
公开(公告)日：2024-07-04
申请号：US18569473
申请日：2022-06-30
IPC分类号： G01N27/327 , C12Q1/6827 , C12Q1/6837 , C12Q1/6876 , G01N27/413
CPC分类号： G01N27/3276 , C12Q1/6837 , C12Q1/6876 , G01N27/3277 , G01N27/413 , C12Q1/6827 , C12Q2600/16 , C12Q2600/178
摘要： This invention discloses a particular photo-electrochemical method for the quantification of biological components involving type II photosensitizers and particles to enhance the photo-electrochemical signal.
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公开(公告)号：US20180067108A1
公开(公告)日：2018-03-08
申请号：US15702938
申请日：2017-09-13
IPC分类号： G01N33/543 , G01N33/94 , G01N33/544 , G01N33/53 , G01N27/327
CPC分类号： G01N33/5438 , G01N27/3275 , G01N33/5308 , G01N33/5436 , G01N33/544 , G01N33/9413 , G01N33/9446 , G01N33/946 , G01N2333/78
摘要： This invention provides:—an aptamer-based electrochemical sensor, wherein said aptamer is covalently bonded to or chemisorbed on an electrode, said aptamer forming a complex with a target molecule and is encapsulated by a gelatin B matrix;—a method of manufacturing said aptamer-based electrochemical sensor;—the use of the aptamer-based electrochemical sensor for the electrochemical determination of a concentration of a target molecule; and—a composite electrode combining a polymeric material and electrically conducting particles for selective analyte detection, wherein said electrode is coated with gelatin type B.
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公开(公告)号：US20220326172A1
公开(公告)日：2022-10-13
申请号：US17638370
申请日：2020-08-31
摘要： A source of formaldehyde for methylating a primary or secondary amine is part of an electrochemical measurement. The source of formaldehyde may be an adduct of formaldehyde.
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公开(公告)号：US20160377606A1
公开(公告)日：2016-12-29
申请号：US14901760
申请日：2014-07-03
IPC分类号： G01N33/543 , G01N27/327 , G01N33/94 , G01N33/53 , G01N33/544
CPC分类号： G01N33/5438 , G01N27/3275 , G01N33/5308 , G01N33/5436 , G01N33/544 , G01N33/9413 , G01N33/9446 , G01N33/946 , G01N2333/78
摘要： This invention provides: —an aptamer-based electrochemical sensor, wherein said aptamer is covalently bonded to or chemisorbed on an electrode, said aptamer forming a complex with a target molecule and is encapsulated by a gelatin B matrix; —a method of manufacturing said aptamer-based electrochemical sensor; —the use of the aptamer-based electrochemical sensor for the electrochemical determination of a concentration of a target molecule; and —a composite electrode combining a polymeric material and electrically conducting particles for selective analyte detection, wherein said electrode is coated with gelatin type B.
摘要翻译： 本发明提供： - 基于适体的电化学传感器，其中所述适体共价结合或电化学吸附在电极上，所述适体与靶分子形成复合物并被明胶B基质包封; - 制造所述基于适体的电化学传感器的方法; - 使用基于适体的电化学传感器用于电化学测定靶分子的浓度; 和 - 复合电极，其组合聚合材料和用于选择性分析物检测的导电颗粒，其中所述电极用B型明胶涂覆。
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