公开(公告)号：US20250003991A1

公开(公告)日：2025-01-02

申请号：US18690572

申请日：2022-09-09

Applicant: Universitair Zeikenhuis Antwerpen ,  Universiteit Antwerpen

Inventor： Matthias CUYKX ,  Bart PEETERS ,  Herman GOOSSENS

IPC: G01N33/72 ,  G01N21/31

Abstract: Provided herein is a method for determining a concentration of a hemoprotein in a test sample, wherein the hemoprotein comprises heme prosthetic group containing porphyrin, the method comprising contacting the test sample with a modification composition comprising at least one modification reagent for degrading the porphyrin, measuring spectrophotometrically a change in an absorbance profile of the porphyrin caused by the degradation, wherein the absorbance profile is measured within a spectrophotometric range of between 510 nm and 590 nm, and determining from the change in the absorbance profile, the concentration of hemoprotein in the sample.

公开(公告)号：US20240383218A1

公开(公告)日：2024-11-21

申请号：US18690996

申请日：2022-09-01

Applicant: FETTE COMPACTING GmbH ,  UNIVERSITEIT ANTWERPEN

Inventor： Nicolas Walter ,  Wouter Grymonpré ,  Joris Vanderputten ,  Jozef Verheyen ,  Jan Vogeleer ,  Serge Tavernier ,  Jef Wens

IPC: B30B15/30 ,  B65D88/66

Abstract: A feeding system for feeding a powder material to a moving powder mass includes a moving device structured to move the powder mass along a movement direction and a feeding reservoir that is structured to provide the powder material to be fed to the moving mass. The feeding reservoir includes a plurality of feeding openings dimensioned for feeding the powder material to the moving powder mass. At least some of the plurality of feeding openings being arranged along the movement direction of the moving powder mass.

公开(公告)号：US20240336573A1

公开(公告)日：2024-10-10

申请号：US18744429

申请日：2024-06-14

Applicant: Eberhard Karls Universität Tübingen Medizinische Fakultät ,  Universiteit Antwerpen

Inventor： Monika Schütz ,  Fabian Renschler ,  Jonas Malte Schweers ,  Ingo Autenrieth ,  Antti Poso ,  Thales Kronenberger ,  Koen Augustyns ,  Milla Kurki ,  Niccolo Cantini ,  Sophie Valembois

IPC: C07D233/90 ,  A61K31/4174 ,  A61P31/04

CPC classification number: C07D233/90 ,  A61K31/4174 ,  A61P31/04

Abstract: The invention relates to a novel compound for the treatment and prophylaxis of a disease, especially a bacterial infectious disease, for reducing pathogen virulence and promoting host-induced clearance of infection and/or sensitizing bacteria to antibiotic treatment, a method for preparing said compound, a pharmaceutical composition comprising said compound, and to a method for the treatment and/or prophylaxis of a disease, preferably a bacterial infectious disease.

公开(公告)号：US20240156935A1

公开(公告)日：2024-05-16

申请号：US18552827

申请日：2022-03-31

Applicant: VIB VZW ,  Vrije Universiteit Brussel ,  Universiteit Antwerpen

Inventor： Benoit Stijlemans

IPC: A61K39/005 ,  A61K39/00 ,  A61K39/002 ,  A61K39/008 ,  A61P37/04

CPC classification number: A61K39/005 ,  A61K39/002 ,  A61K39/008 ,  A61P37/04 ,  A61K2039/53

Abstract: The present invention provides vaccines and compositions, methods and uses of immunogenic vaccine compositions for eliciting an immune response to members of trypanosomatids such as Trypanosoma brucei, T. cruzi and Leishmania species.

公开(公告)号：US20240038483A1

公开(公告)日：2024-02-01

申请号：US18265897

申请日：2021-12-09

Applicant: UNIVERSITEIT ANTWERPEN

Inventor： Adrian Pedrazo Tardajos ,  Sara Bals

IPC: H01J37/20 ,  C23C16/26 ,  C23C16/56

CPC classification number: H01J37/20 ,  C23C16/26 ,  C23C16/56 ,  H01J2237/2001

Abstract: The present disclosure relates to a sample support device for charged particle microscopy and related methods. The device comprises a substrate and a heating and/or biasing element integrated in or on the substrate to heat (or apply a bias voltage to) a sample when positioned in an observation region of the device. The device comprises a membrane covering an opening in the heater element and/or substrate in the observation region of the device. The membrane is perforated to form at least one hole covered by a graphene layer to form a sample support to place a sample of interest thereon for study. A cap covers the membrane such that a chamber is formed in which the sample can be isolated in a controllable gaseous environment.

公开(公告)号：US20240024671A1

公开(公告)日：2024-01-25

申请号：US18223218

申请日：2023-07-18

Applicant: Universiteit Antwerpen ,  Universitair Ziekenhuis Antwerpen

Inventor： Stefan De Wachter

IPC: A61N1/36

CPC classification number: A61N1/36007 ,  A61N1/36178 ,  A61N1/36175 ,  A61N1/36171 ,  A61N1/36139

Abstract: The application discloses methods of ensuring pelvic health and/or treating a disease or disorder characterized by a dysfunctional autonomous nervous system in a subject with neuromodulation. The methods are characterized by the application of a burst stimulation pattern comprising a plurality of groups of electric pulses of high frequencies to the subject.

公开(公告)号：US20230307207A1

公开(公告)日：2023-09-28

申请号：US18017575

申请日：2021-07-09

Applicant: UNIVERSITEIT ANTWERPEN ,  IMEC VZW

Inventor： Jan SIJBERS ,  Jan DE BEENHOUWER ,  Yu-Ting LING ,  Wilfried VANDERVORST

IPC: H01J37/26 ,  G01N23/046

CPC classification number: H01J37/26 ,  G01N23/046 ,  G01N2223/401

Abstract: A method for determining a three-dimensional atomic distribution of a sample having a tip, during an atom probe tomography process. The method accounts for the tip not being axial symmetric and not having a hemispherical shaped apex throughout the evaporation process.

公开(公告)号：US11717164B2

公开(公告)日：2023-08-08

申请号：US16955035

申请日：2018-12-18

Applicant: UNIVERSITEIT ANTWERPEN

Inventor： Stijn Verwulgen ,  Steven Truijen ,  Jochen Vleugels

IPC: A61B5/00 ,  A61B5/30

CPC classification number: A61B5/0053 ,  A61B5/30 ,  A61B5/4312 ,  A61B5/4878 ,  A61B5/6885 ,  A61B5/742 ,  A61B5/7405 ,  A61B5/7455 ,  A61B2560/0223

Abstract: A device for measuring elasticity of a tissue of an object is disclosed. It comprises a base portion comprising contact means for contacting the tissue. It also comprises a palpation probe for pushing down on the tissue comprising a palpation pen for pushing down the tissue and a force measuring means for determining a palpation force applied to the palpation probe and/or a displacement measuring means for determining a displacement of the palpation pen being representative for a displacement of the tissue. The device also comprises a swiveling handle mounted pivotally to the base portion for positioning the device and for distributing a positioning force along the at least two contact points in a predetermined manner.

公开(公告)号：US20230183807A1

公开(公告)日：2023-06-15

申请号：US17436485

申请日：2020-03-04

Applicant: UNIVERSITAIR ZIEKENHUIS ANTWERPEN ,  Universiteit Antwerpen

Inventor： Joe Ibrahim ,  Ken Op de Beeck ,  Arvid Suls ,  Guido Van Camp ,  Marc Peeters

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: The present invention applies to the area of cancer diagnostics. In particular, the present invention is directed to a method for the ex vivo differential diagnosis between several cancer types in a subject based on the methylation status of the Gasdermin E (GSDME) gene. In a further aspect, the present invention relates to a method for the ex vivo differential diagnosis between several cancer types based on the methylation status of at least 2 CpG sites in the GSDME gene.

公开(公告)号：US20230168243A1

公开(公告)日：2023-06-01

申请号：US17912902

申请日：2021-03-23

Applicant: Universiteit Antwerpen ,  Universitair Ziekenhuis Antwerpen

Inventor： Didier EBO ,  Vito SABATO ,  Christel MERTENS ,  Jessy ELST

IPC: G01N33/50

CPC classification number: G01N33/5047 ,  G01N2800/24

Abstract: Provided herein are in vitro methods for diagnosing an immediate hypersensitivity reaction (IHR) against a small compound or a drug in a subject, comprising the steps of (a) contacting mast cells with serum obtained from said subject; (b) contacting the mast cells obtained in step (a) with said small compound or said drug; (c) detecting mast cell activation and/or degranulation of the mast cells obtained in step (b); and (d) attributing the detection or no detection of mast cell activation and/or degranulation to a particular diagnosis of IHR.