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公开(公告)号：US11911464B2
公开(公告)日：2024-02-27
申请号：US17275892
申请日：2019-09-13
Inventor： Paul Davis , Samer Al-Murrani
IPC: A61K39/39 , A61P33/02 , A61K39/002 , A61K39/005 , A61K39/008 , A61K39/012 , A61K39/015 , A61K39/018 , A61K39/00
CPC classification number: A61K39/39 , A61K39/002 , A61K39/005 , A61K39/008 , A61K39/012 , A61K39/015 , A61K39/018 , A61P33/02 , A61K2039/55516 , A61K2039/6031 , A61K2039/627
Abstract: Anti-parasitic compounds and uses thereof. Compounds comprising a C-terminal peptide adjuvant conjugated to an N-terminal peptide antigen via a protease-cleavable linker, said peptide adjuvant comprising a peptide analog of C5a, wherein said peptide antigen comprises an antigenic epitope of a parasitic organism, such as T. gondii. Methods of therapeutic or prophylactic treatment of a parasitic infections.
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公开(公告)号：US20230218749A1
公开(公告)日：2023-07-13
申请号：US17891757
申请日：2022-08-19
Inventor： Kari C. Nadeau
IPC: A61K39/35 , A61K45/06 , A61K9/14 , A61K47/46 , A61K35/60 , A61K35/747 , A61K47/10 , A61K39/005 , A61K31/59 , A61K9/00 , A61K47/44 , A61K31/375 , A61K31/593 , A61K39/00 , A61K35/00
CPC classification number: A61K39/35 , A61K45/06 , A61K9/148 , A61K47/46 , A61K35/60 , A61K35/747 , A61K47/10 , A61K39/005 , A61K31/59 , A61K9/0053 , A61K47/44 , A61K31/375 , A61K31/593 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/542 , A61K2039/55 , A61K2039/575 , A61K2035/115 , A61K2039/70 , A61K2039/572
Abstract: Mixed allergen compositions of two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin. Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.
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公开(公告)号：US09250239B2
公开(公告)日：2016-02-02
申请号：US14175001
申请日：2014-02-07
Applicant: Nisha J. Garg
Inventor： Nisha J. Garg
IPC: G01N33/53 , G01N33/569 , A61K39/005 , A61K39/00
CPC classification number: G01N33/56905 , A61K39/005 , A61K2039/53 , A61K2039/55522 , A61K2039/55538 , A61K2039/55577 , Y02A50/414
Abstract: Provided herein are vaccine compositions for control of Trypanosoma cruzi infection and Chagas disease. The compositions comprise plasmids encoding o GPI-anchored genes ASP-2, TcG-1, TcG2 and TcG4 from Trypanosoma cruzi; plasmids encoding cytokines IL12 and GM-CSF; and plasmids encoding a gene expression system. Certain vaccine compositions comprise recombinant proteins, selected from TcG-1, TcG2 and TcG4 from Trypanosoma cruzi. In another vaccination strategy, the recombinant proteins are replaced by lysates comprising Trypanosoma rangeli cells. Further provided herein are diagnosis compositions comprising 1) recombinant proteins, selected from TcG-1, TcG2 and TcG4 from Trypanosoma cruzi; 2) antibodies that specifically binds the TcG-1, TcG2 and TcG4 proteins; 3) sense and antisense polynucleotide sequences that encode the TcG-1, TcG2 and TcG4 proteins. Said compositions can be used in diagnosing and/or evaluating efficacy of treatments against Trypanosoma cruzi infection. A diagnosis kit, and methods of diagnosing and/or treating Trypanosoma cruzi infection are also provided.
Abstract translation: 本文提供了用于控制克氏锥虫感染和恰加斯病的疫苗组合物。 组合物包含编码来自锥虫的GPI锚定基因ASP-2，TcG-1，TcG2和TcG4的质粒; 编码细胞因子IL12和GM-CSF的质粒; 和编码基因表达系统的质粒。 某些疫苗组合物包含选自克氏锥虫的TcG-1，TcG2和TcG4的重组蛋白。 在另一种疫苗接种策略中，重组蛋白由包含锥虫属细胞的裂解物替代。 本文进一步提供的诊断组合物包括：1）选自TcG-1，TcG2和TcG4的克隆重组蛋白; 2）特异性结合TcG-1，TcG2和TcG4蛋白的抗体; 3）编码TcG-1，TcG2和TcG4蛋白质的有义和反义多核苷酸序列。 所述组合物可用于诊断和/或评估针对克氏锥虫感染的治疗效果。 还提供诊断试剂盒以及诊断和/或治疗克氏锥虫感染的方法。
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4.发明授权Multicomponent or monocomponent vaccine to be used against Chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure 有权用于对抗恰加斯病的多组分或单组分疫苗，含有它们的药物组合物，获得所述疫苗的免疫原的程序和所述方法中使用的核酸
公开(公告)号：US08900598B2
公开(公告)日：2014-12-02
申请号：US12740393
申请日：2008-10-30
Applicant: Carlos de Baeremaecker Barros
Inventor： Carlos de Baeremaecker Barros
IPC: A61K39/002 , A61K39/005 , A61K39/00
CPC classification number: A61K39/005 , A61K39/00 , A61K39/002 , A61K2039/53 , A61K2039/55505 , A61K2039/55522 , A61K2039/55527 , Y02A50/414
Abstract: A vaccine against the Chagas disease, capable of stimulating the immune response against the trans-sialidase virulence factor of the Trypanosoma cruzi parasite, which is a multicomponent vaccine comprising: (a) an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of thereof and (b) one or more polynucleotides including the regions codifying one or more immunogenic polypeptides, or a monocomponent vaccine comprising at least one component selected among an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of them and a group of polynucleotides including the regions codifying one or more immunogenic polypeptides derived from Trypanosoma cruzi and pharmaceutical compositions containing said multicomponent and monocomponent vaccines, the procedures for obtaining the immunogen portion of said vaccines and the nucleic acid used in the procedure.
Abstract translation: 一种针对恰加斯病的疫苗，其能够刺激针对克氏锥虫寄生虫的唾液酸酶毒力因子的免疫应答，其是多组分疫苗，其包含：（a）由一种或多种重组或合成多肽或部分形成的免疫原性部分 和（b）一种或多种多核苷酸，包括编码一种或多种免疫原性多肽的区域，或包含至少一种选自由一种或多种重组或合成多肽或其部分形成的免疫原性部分的组分的单组分疫苗和一组 包括编码一种或多种衍生自克氏锥虫的免疫原性多肽的区域的多核苷酸和含有所述多组分和单组分疫苗的药物组合物，获得所述疫苗的免疫原部分的程序和该方法中使用的核酸。
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公开(公告)号：US20140220603A1
公开(公告)日：2014-08-07
申请号：US14175001
申请日：2014-02-07
Applicant: Nisha J. Garg
Inventor： Nisha J. Garg
IPC: G01N33/569
CPC classification number: G01N33/56905 , A61K39/005 , A61K2039/53 , A61K2039/55522 , A61K2039/55538 , A61K2039/55577 , Y02A50/414
Abstract: Provided herein are vaccine compositions for control of Trypanosoma cruzi infection and Chagas disease. The compositions comprise plasmids encoding o GPI-anchored genes ASP-2, TcG-1, TcG2 and TcG4 from Trypanosoma cruzi; plasmids encoding cytokines IL12 and GM-CSF; and plasmids encoding a gene expression system. Certain vaccine compositions comprise recombinant proteins, selected from TcG-1, TcG2 and TcG4 from Trypanosoma cruzi. In another vaccination strategy, the recombinant proteins are replaced by lysates comprising Trypanosoma rangeli cells. Further provided herein are diagnosis compositions comprising 1) recombinant proteins, selected from TcG-1, TcG2 and TcG4 from Trypanosoma cruzi; 2) antibodies that specifically binds the TcG-1, TcG2 and TcG4 proteins; 3) sense and antisense polynucleotide sequences that encode the the TcG-1, TcG2 and TcG4 proteins. Said compositions can be used in diagnosing and/or evaluating efficacy of treatments against Trypanosoma cruzi infection. A diagnosis kit, and methods of diagnosing and/or treating Trypanosoma cruzi infection are also provided.
Abstract translation: 本文提供了用于控制克氏锥虫感染和恰加斯病的疫苗组合物。 组合物包含编码来自锥虫的GPI锚定基因ASP-2，TcG-1，TcG2和TcG4的质粒; 编码细胞因子IL12和GM-CSF的质粒; 和编码基因表达系统的质粒。 某些疫苗组合物包含选自克氏锥虫的TcG-1，TcG2和TcG4的重组蛋白。 在另一种疫苗接种策略中，重组蛋白由包含锥虫属细胞的裂解物替代。 本文进一步提供的诊断组合物包括：1）选自TcG-1，TcG2和TcG4的克隆重组蛋白; 2）特异性结合TcG-1，TcG2和TcG4蛋白的抗体; 3）编码TcG-1，TcG2和TcG4蛋白质的有义和反义多核苷酸序列。 所述组合物可用于诊断和/或评估针对克氏锥虫感染的治疗效果。 还提供诊断试剂盒以及诊断和/或治疗克氏锥虫感染的方法。
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公开(公告)号：US20110038887A1
公开(公告)日：2011-02-17
申请号：US12225396
申请日：2007-03-14
Applicant: Roland Contreras , Kristof De Vusser , Silvia Revelli
Inventor： Roland Contreras , Kristof De Vusser , Silvia Revelli
IPC: A61K39/005 , C07K14/44 , C07K19/00 , A61P33/02
CPC classification number: A61K39/005 , A61K38/16 , C07K14/44 , Y02A50/414
Abstract: The present invention relates to a vaccine against Trypanosoma cruzi infection, useful in the prevention and/or treatment of the Chagas disease. More specifically, the present invention relates to a recombinant mutant trans-sialidase enzyme that can be used as an efficient vaccine, without side effects.
Abstract translation: 本发明涉及可用于预防和/或治疗恰加斯病的克氏锥虫感染疫苗。 更具体地，本发明涉及可用作有效疫苗的重组突变体唾液酸酶，无副作用。
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公开(公告)号：US20100297187A1
公开(公告)日：2010-11-25
申请号：US12677682
申请日：2008-09-05
Applicant: Gregory Alan Stoloff , Wilson Romero Caparros-Wanderley
Inventor： Gregory Alan Stoloff , Wilson Romero Caparros-Wanderley
IPC: A61K39/015 , C07K14/435 , C07K7/08 , C07H21/04 , A61P33/06
CPC classification number: C07K14/43577 , A61K38/00 , A61K39/005 , A61K2039/53 , Y10S530/806 , Y10S530/855 , Y10S530/858
Abstract: Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognising at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40 kDA or less, and wherein the polypeptides are selected independently from: the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.
Abstract translation: 提供了包含一种或多种多肽的多肽组合物，该多肽在脊椎动物中具有免疫原性，使得它们使脊椎动物产生能够识别节肢动物唾液蛋白质级分中的至少一种表位的免疫系统细胞，其中节肢动物唾液蛋白质级分具有 质量为40kDA或更小，并且其中所述多肽独立地选自：SEQ ID 1-44的多肽序列或来自这些序列的亚序列，所述亚序列具有7个氨基酸或更多个; 或来自与上述一个或多个序列具有85％同源性或更多同源性的多肽序列并且包含在一个或多个以下数据库中：GenBank，蛋白质数据库（PDB），SwissProt，蛋白质信息资源（PIR），蛋白质研究基金会 （PRF）或这些的CDS翻译。
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8.发明申请MULTICOMPONENT OR MONOCOMPONENT VACCINE TO BE USED AGAINST CHAGAS DISEASE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCEDURE FOR THE OBTENTION OF IMMUNOGEN OF SAID VACCINES, AND NUCLEIC ACID USED IN SAID PROCEDURE 有权用于灭菌疫苗的多种或多种单克隆疫苗，含有它们的药物组合物，阻止免疫原性免疫球蛋白的程序，以及按照程序使用的核酸
公开(公告)号：US20100297186A1
公开(公告)日：2010-11-25
申请号：US12740393
申请日：2008-10-30
Applicant: Carlos de Baeremaecker Barros
Inventor： Carlos de Baeremaecker Barros
IPC: A61K39/005 , A61P31/04 , A61P37/04
CPC classification number: A61K39/005 , A61K39/00 , A61K39/002 , A61K2039/53 , A61K2039/55505 , A61K2039/55522 , A61K2039/55527 , Y02A50/414
Abstract: A vaccine against the Chagas disease, capable of stimulating the immune response against the trans-sialidase virulence factor of the Trypanosoma Cruzi parasite, which is a multicomponent vaccine comprising: (a) an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of thereof and (b) one or more polynucleotides including the regions that codifying one or more immunogenic polypeptides, or a monocomponent comprising at least one component selected among an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of them and a group of polynucleotides including the regions codifying one or more immunogenic polypeptides derived from Trypanosoma Cruzi and pharmaceutical compositions containing said multicomponent and monocomponent vaccines, the procedures for obtaining the immunogen portion of said vaccines and the nucleic acid used in the procedure.
Abstract translation: 一种针对恰加斯病的疫苗，其能够刺激针对锥虫克鲁日寄生虫的唾液酸酶毒力因子的免疫应答，其为多组分疫苗，其包含：（a）由一种或多种重组或合成多肽或部分形成的免疫原性部分 和（b）一种或多种多核苷酸，包括编码一种或多种免疫原性多肽的区域，或包含至少一种选自由一种或多种重组或合成多肽或其部分形成的免疫原性部分的组分的单组分和一组 包括编码一种或多种衍生自锥虫属的免疫原性多肽的区域的多核苷酸和含有所述多组分和单组分疫苗的药物组合物，获得所述疫苗的免疫原部分的程序和该方法中使用的核酸。
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公开(公告)号：US20100047329A1
公开(公告)日：2010-02-25
申请号：US12223722
申请日：2007-02-07
Applicant: Shinobu Watarai , Kenji Kono
Inventor： Shinobu Watarai , Kenji Kono
CPC classification number: A61K39/39 , A61K9/127 , A61K9/1272 , A61K39/005 , A61K39/0208 , A61K39/0241 , A61K39/085 , A61K39/12 , A61K39/17 , A61K2039/521 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55555 , C12N2760/18111 , C12N2760/18134 , C12N2760/18151
Abstract: An object of the present invention is to prepare novel vaccine carriers that can be used to produce vaccines that are capable of efficient induction of humoral and cellular immune responses. Another object of the present invention is to provide vaccines that are capable of efficient induction of humoral and cellular immune responses.The present inventors revealed that the above-stated objects of the present invention could be attained by using liposomes containing succinylated poly(glycidol) and this finding has led to the accomplishment of the invention. Stated specifically, the present invention can attain the aforementioned objects by providing vaccine carriers comprising liposomes containing succinylated poly(glycidol).
Abstract translation: 本发明的目的是制备可用于产生能够有效诱导体液和细胞免疫应答的疫苗的新型疫苗载体。 本发明的另一个目的是提供能够有效诱导体液和细胞免疫应答的疫苗。 本发明人揭示了本发明的上述目的可以通过使用含有琥珀酰化聚（缩水甘油）的脂质体来实现，这一发现导致了本发明的实现。 特别地，本发明可以通过提供包含含有琥珀酰化聚（缩水甘油）的脂质体的疫苗载体来实现上述目的。
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公开(公告)号：US20080241075A1
公开(公告)日：2008-10-02
申请号：US11856036
申请日：2007-09-15
Applicant: William Snell , Yanjie Liu , Robert Sinden , Oliver Billker
Inventor： William Snell , Yanjie Liu , Robert Sinden , Oliver Billker
CPC classification number: A61K39/018 , A61K39/002 , A61K39/005 , A61K39/012 , A61K39/015 , A61K2039/55566 , A61K2039/55572 , C07K14/44 , Y02A50/412 , Y02A50/489
Abstract: The present invention includes compositions and methods for the development and use of a vaccine that includes one or more FusM antigens in a carrier adapted to trigger a FusM-specific immune response in the human blood stream.
Abstract translation: 本发明包括用于开发和使用疫苗的组合物和方法，所述疫苗在适于触发人血液中的FusM特异性免疫应答的载体中包含一种或多种FusM抗原。
