公开(公告)号：US20230176071A1

公开(公告)日：2023-06-08

申请号：US17923904

申请日：2021-05-06

Applicant: UCB BIOPHARMA SRL

Inventor： Anastasios SPILIOTOPOULOS ,  David James MCMILLAN ,  Michael John Wright ,  Sebastian KELM ,  Xiaofeng LIU ,  Daniel John LIGHTWOOD

IPC: G01N33/68

CPC classification number: G01N33/6857

Abstract: A method of identifying of amino-acid residues on a target protein that form a binding site of a molecule of interest. Such method relies on selection of relevant patches of solvent-accessible residues and testing of an array of mutated proteins for changes of binding properties. Such method is useful for determining binding sites (epitopes) of antibodies, ligands and related molecules.

公开(公告)号：US20240254224A1

公开(公告)日：2024-08-01

申请号：US18558686

申请日：2022-05-02

Applicant: UCB BIOPHARMA SRL

Inventor： Daniel John LIGHTWOOD ,  Irena KADIU ,  Pallavi BHATTA ,  Anastasios SPILIOTOPOULOS ,  Peter Charles ELLIOTT ,  James Martin KEANEY ,  Silvia L. DELKER ,  Jan ABENDROTH

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/28

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to antibodies binding to TREM1 and inhibiting its interaction with one or more of its natural ligands. Specific examples of such antibodies are provided. The therapeutic uses of the antibodies and methods of generating such are also provided.

公开(公告)号：US20240024520A1

公开(公告)日：2024-01-25

申请号：US17907116

申请日：2021-03-26

Applicant: UCB BIOPHARMA SRL

Inventor： Alastair David Griffiths LAWSON ,  Alexander MACPHERSON ,  Anthony SCOTT-TUCKER ,  Anastasios SPILIOTOPOULOS

IPC: A61K51/10 ,  C07K16/18 ,  C12N15/10

CPC classification number: A61K51/1096 ,  C07K16/18 ,  C12N15/1037 ,  C07K2317/20 ,  C07K2317/24

Abstract: The present disclosure relates to isolated fragments of antibodies, in particular to isolated knob domains of bovine ultralong CDR-H3 or portions thereof which bind to an antigen of interest, and formulations comprising the same. The disclosure further relates to the use of the isolated antibody fragments and formulations in therapy. The present disclosure also extends to methods of preparing said isolated antibody fragments.

公开(公告)号：US20230406924A1

公开(公告)日：2023-12-21

申请号：US18251006

申请日：2020-11-02

Applicant: UCB BIOPHARMA SRL

Inventor： Irena KADIU ,  Julien GASSER ,  James Martin KEANEY ,  Anastasios SPILIOTOPOULOS ,  Jonathan Mark PHILLIPS

IPC: C07K16/28 ,  A61P25/28

CPC classification number: C07K16/2803 ,  A61P25/28 ,  C07K2317/92

Abstract: The present invention provides antibodies or antigen-binding fragment thereof that bind and neutralize TREM1 for use in the treatment of a motor neuron degenerative disorders, in particular amyotrophic lateral sclerosis.