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公开(公告)号：US20250012807A1
公开(公告)日：2025-01-09
申请号：US18818247
申请日：2024-08-28
Applicant: UCB BIOPHARMA SRL
Inventor： James Philip O'CONNELL , John Robert PORTER , Alastair LAWSON , Boris KROEPLIEN , Stephen Edward RAPECKI , Timothy John NORMAN , David James MCMILLAN , Graham John WARRELLOW , Daniel Christopher BROOKINGS , Rikki Peter ALEXANDER
IPC: G01N33/68 , A61K47/64 , A61P35/00 , A61P37/00 , C07D213/72 , C07D235/04 , C07D239/26 , C07D401/14 , C07D471/00 , C07D471/04 , C07K14/525 , C07K14/705 , C07K16/24
Abstract: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.
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公开(公告)号：US20220340648A1
公开(公告)日：2022-10-27
申请号：US17682082
申请日：2022-02-28
Applicant: UCB Biopharma SRL
Inventor： Patrick DOWNEY , Kerry Louise TYSON , Marco KRIEK , Lorenzo DE LICHTERVELDE , Daniel John LIGHTWOOD , David James MCMILLAN , Peter Charles ELLIOT , Terence Seward BAKER
Abstract: The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.
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公开(公告)号：US20230176071A1
公开(公告)日：2023-06-08
申请号：US17923904
申请日：2021-05-06
Applicant: UCB BIOPHARMA SRL
Inventor： Anastasios SPILIOTOPOULOS , David James MCMILLAN , Michael John Wright , Sebastian KELM , Xiaofeng LIU , Daniel John LIGHTWOOD
IPC: G01N33/68
CPC classification number: G01N33/6857
Abstract: A method of identifying of amino-acid residues on a target protein that form a binding site of a molecule of interest. Such method relies on selection of relevant patches of solvent-accessible residues and testing of an array of mutated proteins for changes of binding properties. Such method is useful for determining binding sites (epitopes) of antibodies, ligands and related molecules.
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公开(公告)号：US20230070261A1
公开(公告)日：2023-03-09
申请号：US17759988
申请日：2021-02-01
Applicant: UCB BIOPHARMA SRL
Inventor： Neesha DEDI , Peter Charles ELLIOTT , Seppe Frans Roman LEYSEN , Sean MASON , David James MCMILLAN , Gillian Claire NESS , Niccolo PENGO , Martin Anthony REDHEAD , Alison TURNER , Kerry Louise TYSON
IPC: C07K16/40
Abstract: The present invention relates to antibodies which bind and inhibit KLK5 and methods of using the same to treat diseases caused by KLK5 imbalance. In particular, the present invention relates to inhibitory anti-KLK5 antibodies and their use in the treatment of Netherton disease, atopic dermatitis and cancer.
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Patent Agency Ranking
公开(公告)号：US20210107971A1
公开(公告)日：2021-04-15
申请号：US16771993
申请日：2018-12-13
Applicant: UCB Biopharma SRL
Inventor： Ralph ADAMS , Patrick DOWNEY , Terence Seward BAKER , Kerry Louise TYSON , Lorenzo DE LICHTERVELDE , Daniel John LIGHTWOOD , David James MCMILLAN
IPC: C07K16/18
Abstract: The present invention relates to antibodies binding alpha synuclein and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.
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公开(公告)号：US20230075753A1
公开(公告)日：2023-03-09
申请号：US17759986
申请日：2021-02-01
Applicant: UCB BIOPHARMA SRL
Inventor： Neesha DEDI , Peter Charles ELLIOTT , Seppe Frans Roman LEYSEN , Sean MASON , David James MCMILLAN , Gillian Claire NESS , Niccolo PENGO , Martin Anthony REDHEAD , Alison TURNER , Kerry Louise TYSON
Abstract: The present invention relates to antibodies which bind and inhibit KLK5 and methods of using the same to treat diseases caused by KLK5 imbalance. In particular, the present invention relates to inhibitory antibodies binding KLK5 and their use in the treatment of Netherton disease, atopic dermatitis and cancer.
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公开(公告)号：US20220220192A1
公开(公告)日：2022-07-14
申请号：US17585174
申请日：2022-01-26
Applicant: UCB BIOPHARMA SRL
Inventor： Ralph ADAMS , Patrick DOWNEY , Terence Seward BAKER , Kerry Louise TYSON , Lorenzo DE LICHTERVELDE , Daniel John LIGHTWOOD , David James MCMILLAN
IPC: C07K16/18
Abstract: The present invention relates to antibodies binding alpha synuclein and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.
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公开(公告)号：US20210140972A1
公开(公告)日：2021-05-13
申请号：US17072665
申请日：2020-10-16
Applicant: UCB BIOPHARMA SRL
Inventor： James Philip O'CONNELL , John Robert PORTER , Alastair LAWSON , Boris KROEPLIEN , Stephen Edward RAPECKI , Timothy John NORMAN , David James MCMILLAN , Graham John WARRELLOW , Daniel Christopher BROOKINGS , Rikki Peter ALEXANDER
IPC: G01N33/68 , C07D401/14 , C07K14/525 , C07D471/00 , C07K14/705 , C07K16/24 , C07D213/72 , C07D235/04 , C07D239/26 , C07D471/04 , A61K47/64 , A61P37/00 , A61P35/00
Abstract: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.
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公开(公告)号：US20210101964A1
公开(公告)日：2021-04-08
申请号：US16772043
申请日：2018-12-13
Applicant: UCB Biopharma SRL
Inventor： Patrick DOWNEY , Kerry Louise TYSON , Marco KRIEK , Lorenzo DE LICHTERVELDE , Daniel John LIGHTWOOD , David James MCMILLAN , Peter Charles ELLIOTT , Terence Seward BAKER
Abstract: The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.
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