公开(公告)号：US20230075753A1

公开(公告)日：2023-03-09

申请号：US17759986

申请日：2021-02-01

Applicant: UCB BIOPHARMA SRL

Inventor： Neesha DEDI ,  Peter Charles ELLIOTT ,  Seppe Frans Roman LEYSEN ,  Sean MASON ,  David James MCMILLAN ,  Gillian Claire NESS ,  Niccolo PENGO ,  Martin Anthony REDHEAD ,  Alison TURNER ,  Kerry Louise TYSON

IPC: C07K16/40 ,  C12N15/63 ,  A61P17/00

Abstract: The present invention relates to antibodies which bind and inhibit KLK5 and methods of using the same to treat diseases caused by KLK5 imbalance. In particular, the present invention relates to inhibitory antibodies binding KLK5 and their use in the treatment of Netherton disease, atopic dermatitis and cancer.

公开(公告)号：US20230070261A1

公开(公告)日：2023-03-09

申请号：US17759988

申请日：2021-02-01

Applicant: UCB BIOPHARMA SRL

Inventor： Neesha DEDI ,  Peter Charles ELLIOTT ,  Seppe Frans Roman LEYSEN ,  Sean MASON ,  David James MCMILLAN ,  Gillian Claire NESS ,  Niccolo PENGO ,  Martin Anthony REDHEAD ,  Alison TURNER ,  Kerry Louise TYSON

IPC: C07K16/40

Abstract: The present invention relates to antibodies which bind and inhibit KLK5 and methods of using the same to treat diseases caused by KLK5 imbalance. In particular, the present invention relates to inhibitory anti-KLK5 antibodies and their use in the treatment of Netherton disease, atopic dermatitis and cancer.