公开(公告)号：US20250012807A1

公开(公告)日：2025-01-09

申请号：US18818247

申请日：2024-08-28

Applicant: UCB BIOPHARMA SRL

Inventor： James Philip O'CONNELL ,  John Robert PORTER ,  Alastair LAWSON ,  Boris KROEPLIEN ,  Stephen Edward RAPECKI ,  Timothy John NORMAN ,  David James MCMILLAN ,  Graham John WARRELLOW ,  Daniel Christopher BROOKINGS ,  Rikki Peter ALEXANDER

IPC: G01N33/68 ,  A61K47/64 ,  A61P35/00 ,  A61P37/00 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D401/14 ,  C07D471/00 ,  C07D471/04 ,  C07K14/525 ,  C07K14/705 ,  C07K16/24

Abstract: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

公开(公告)号：US20210140972A1

公开(公告)日：2021-05-13

申请号：US17072665

申请日：2020-10-16

Applicant: UCB BIOPHARMA SRL

Inventor： James Philip O'CONNELL ,  John Robert PORTER ,  Alastair LAWSON ,  Boris KROEPLIEN ,  Stephen Edward RAPECKI ,  Timothy John NORMAN ,  David James MCMILLAN ,  Graham John WARRELLOW ,  Daniel Christopher BROOKINGS ,  Rikki Peter ALEXANDER

IPC: G01N33/68 ,  C07D401/14 ,  C07K14/525 ,  C07D471/00 ,  C07K14/705 ,  C07K16/24 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D471/04 ,  A61K47/64 ,  A61P37/00 ,  A61P35/00

Abstract: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

公开(公告)号：US20240294534A1

公开(公告)日：2024-09-05

申请号：US18572274

申请日：2022-06-30

Applicant: UCB BIOPHARMA SRL

Inventor： Gareth Neil BRACE ,  Daniel Christopher BROOKINGS ,  Shuyu CHU ,  Rickki Lee CONNELLY ,  Anne Marie FOLEY ,  James Richard FROST ,  Ellen Olivia GALLIMORE ,  Paul GOLDSMITH ,  James Andrew JOHNSON ,  James Thomas REUBERSON ,  Robert STRAKER ,  Richard David TAYLOR ,  Luigi Piero STASI

IPC: C07D487/04 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541

CPC classification number: C07D487/04 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541

Abstract: A series of substituted imidazo[1,2-b][1,2,4]triazine derivatives of formula (I), being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.