公开(公告)号：US20240294534A1

公开(公告)日：2024-09-05

申请号：US18572274

申请日：2022-06-30

Applicant: UCB BIOPHARMA SRL

Inventor： Gareth Neil BRACE ,  Daniel Christopher BROOKINGS ,  Shuyu CHU ,  Rickki Lee CONNELLY ,  Anne Marie FOLEY ,  James Richard FROST ,  Ellen Olivia GALLIMORE ,  Paul GOLDSMITH ,  James Andrew JOHNSON ,  James Thomas REUBERSON ,  Robert STRAKER ,  Richard David TAYLOR ,  Luigi Piero STASI

IPC: C07D487/04 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541

CPC classification number: C07D487/04 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541

Abstract: A series of substituted imidazo[1,2-b][1,2,4]triazine derivatives of formula (I), being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US20250134890A1

公开(公告)日：2025-05-01

申请号：US18835890

申请日：2023-02-03

Applicant: UCB BIOPHARMA SRL

Inventor： Jeffrey BRUFFAERTS ,  Teresa DE HARO GARCIA ,  Martin Alexander LOWE ,  Komei SAKATA ,  Luigi Piero STASI ,  Richard David TAYLOR ,  Lewis Robin ,  Mengyang XUAN

IPC: A61K31/513 ,  A61K31/675 ,  A61P33/06 ,  C07D239/22 ,  C07D405/04 ,  C07D405/14 ,  C07F9/6558

Abstract: A series of 2-imino-6-methylhexahydropyrimidin-4-one derivatives, substituted in the 6-position by an arylphenyl or heteroarylphenyl moiety, being potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood, are beneficial as pharmaceutical agents, especially in the treatment of malaria.