公开(公告)号：US20240294534A1

公开(公告)日：2024-09-05

申请号：US18572274

申请日：2022-06-30

Applicant: UCB BIOPHARMA SRL

Inventor： Gareth Neil BRACE ,  Daniel Christopher BROOKINGS ,  Shuyu CHU ,  Rickki Lee CONNELLY ,  Anne Marie FOLEY ,  James Richard FROST ,  Ellen Olivia GALLIMORE ,  Paul GOLDSMITH ,  James Andrew JOHNSON ,  James Thomas REUBERSON ,  Robert STRAKER ,  Richard David TAYLOR ,  Luigi Piero STASI

IPC: C07D487/04 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541

CPC classification number: C07D487/04 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541

Abstract: A series of substituted imidazo[1,2-b][1,2,4]triazine derivatives of formula (I), being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.