公开(公告)号：US20230176071A1

公开(公告)日：2023-06-08

申请号：US17923904

申请日：2021-05-06

Applicant: UCB BIOPHARMA SRL

Inventor： Anastasios SPILIOTOPOULOS ,  David James MCMILLAN ,  Michael John Wright ,  Sebastian KELM ,  Xiaofeng LIU ,  Daniel John LIGHTWOOD

IPC: G01N33/68

CPC classification number: G01N33/6857

Abstract: A method of identifying of amino-acid residues on a target protein that form a binding site of a molecule of interest. Such method relies on selection of relevant patches of solvent-accessible residues and testing of an array of mutated proteins for changes of binding properties. Such method is useful for determining binding sites (epitopes) of antibodies, ligands and related molecules.

公开(公告)号：US20210166780A1

公开(公告)日：2021-06-03

申请号：US16972458

申请日：2019-06-05

Applicant: UCB Biopharma SRL

Inventor： Ralph ADAMS ,  James HEADS ,  Sebastian KELM ,  Alastair David Griffiths LAWSON

IPC: G16B15/20 ,  C07K16/00

Abstract: The present invention provides a method for generation of multi-domain proteins, more particular antibodies, with an improved native state colloidal stability.