公开(公告)号：US20220025033A1

公开(公告)日：2022-01-27

申请号：US17500616

申请日：2021-10-13

Applicant: UCB BIOPHARMA SRL ,  SANOFI

Inventor： Alastair David Griffiths LAWSON ,  Daniel John LIGHTWOOD ,  Rebecca Jayne MUNRO ,  James Philip O'CONNELL ,  John Robert PORTER

IPC: C07K16/24

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

公开(公告)号：US20240024520A1

公开(公告)日：2024-01-25

申请号：US17907116

申请日：2021-03-26

Applicant: UCB BIOPHARMA SRL

Inventor： Alastair David Griffiths LAWSON ,  Alexander MACPHERSON ,  Anthony SCOTT-TUCKER ,  Anastasios SPILIOTOPOULOS

IPC: A61K51/10 ,  C07K16/18 ,  C12N15/10

CPC classification number: A61K51/1096 ,  C07K16/18 ,  C12N15/1037 ,  C07K2317/20 ,  C07K2317/24

Abstract: The present disclosure relates to isolated fragments of antibodies, in particular to isolated knob domains of bovine ultralong CDR-H3 or portions thereof which bind to an antigen of interest, and formulations comprising the same. The disclosure further relates to the use of the isolated antibody fragments and formulations in therapy. The present disclosure also extends to methods of preparing said isolated antibody fragments.

公开(公告)号：US20210166780A1

公开(公告)日：2021-06-03

申请号：US16972458

申请日：2019-06-05

Applicant: UCB Biopharma SRL

Inventor： Ralph ADAMS ,  James HEADS ,  Sebastian KELM ,  Alastair David Griffiths LAWSON

IPC: G16B15/20 ,  C07K16/00

Abstract: The present invention provides a method for generation of multi-domain proteins, more particular antibodies, with an improved native state colloidal stability.