公开(公告)号：US20240024520A1

公开(公告)日：2024-01-25

申请号：US17907116

申请日：2021-03-26

Applicant: UCB BIOPHARMA SRL

Inventor： Alastair David Griffiths LAWSON ,  Alexander MACPHERSON ,  Anthony SCOTT-TUCKER ,  Anastasios SPILIOTOPOULOS

IPC: A61K51/10 ,  C07K16/18 ,  C12N15/10

CPC classification number: A61K51/1096 ,  C07K16/18 ,  C12N15/1037 ,  C07K2317/20 ,  C07K2317/24

Abstract: The present disclosure relates to isolated fragments of antibodies, in particular to isolated knob domains of bovine ultralong CDR-H3 or portions thereof which bind to an antigen of interest, and formulations comprising the same. The disclosure further relates to the use of the isolated antibody fragments and formulations in therapy. The present disclosure also extends to methods of preparing said isolated antibody fragments.