公开(公告)号：US20240254224A1

公开(公告)日：2024-08-01

申请号：US18558686

申请日：2022-05-02

Applicant: UCB BIOPHARMA SRL

Inventor： Daniel John LIGHTWOOD ,  Irena KADIU ,  Pallavi BHATTA ,  Anastasios SPILIOTOPOULOS ,  Peter Charles ELLIOTT ,  James Martin KEANEY ,  Silvia L. DELKER ,  Jan ABENDROTH

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/28

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to antibodies binding to TREM1 and inhibiting its interaction with one or more of its natural ligands. Specific examples of such antibodies are provided. The therapeutic uses of the antibodies and methods of generating such are also provided.