公开(公告)号：US20240254224A1

公开(公告)日：2024-08-01

申请号：US18558686

申请日：2022-05-02

Applicant: UCB BIOPHARMA SRL

Inventor： Daniel John LIGHTWOOD ,  Irena KADIU ,  Pallavi BHATTA ,  Anastasios SPILIOTOPOULOS ,  Peter Charles ELLIOTT ,  James Martin KEANEY ,  Silvia L. DELKER ,  Jan ABENDROTH

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/28

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to antibodies binding to TREM1 and inhibiting its interaction with one or more of its natural ligands. Specific examples of such antibodies are provided. The therapeutic uses of the antibodies and methods of generating such are also provided.

公开(公告)号：US20230406924A1

公开(公告)日：2023-12-21

申请号：US18251006

申请日：2020-11-02

Applicant: UCB BIOPHARMA SRL

Inventor： Irena KADIU ,  Julien GASSER ,  James Martin KEANEY ,  Anastasios SPILIOTOPOULOS ,  Jonathan Mark PHILLIPS

IPC: C07K16/28 ,  A61P25/28

CPC classification number: C07K16/2803 ,  A61P25/28 ,  C07K2317/92

Abstract: The present invention provides antibodies or antigen-binding fragment thereof that bind and neutralize TREM1 for use in the treatment of a motor neuron degenerative disorders, in particular amyotrophic lateral sclerosis.