公开(公告)号：US20230406924A1

公开(公告)日：2023-12-21

申请号：US18251006

申请日：2020-11-02

Applicant: UCB BIOPHARMA SRL

Inventor： Irena KADIU ,  Julien GASSER ,  James Martin KEANEY ,  Anastasios SPILIOTOPOULOS ,  Jonathan Mark PHILLIPS

IPC: C07K16/28 ,  A61P25/28

CPC classification number: C07K16/2803 ,  A61P25/28 ,  C07K2317/92

Abstract: The present invention provides antibodies or antigen-binding fragment thereof that bind and neutralize TREM1 for use in the treatment of a motor neuron degenerative disorders, in particular amyotrophic lateral sclerosis.