公开(公告)号：US20070009493A1

公开(公告)日：2007-01-11

申请号：US11443387

申请日：2006-05-30

Applicant: Susan Drapeau ,  Sangwook Yoon

Inventor： Susan Drapeau ,  Sangwook Yoon

IPC: A61K35/14 ,  C12N5/08

CPC classification number: C12N5/0663 ,  A61K35/28 ,  A61K38/1875 ,  A61K38/57 ,  A61K48/005 ,  C12N2501/998 ,  C12N2502/11

Abstract: The invention provides a method of treatment joint and disk disease comprising administering to the subject in need thereof a novel composition comprising a substantially purified plurality of cells enhanced with at least one bioactive factor capable of causing at least a portion of the plurality of cells to express an increased amount of at least one chondrogenic marker.

Abstract translation: 本发明提供了一种治疗关节和椎间盘疾病的方法，包括向有需要的受试者施用新的组合物，其包含基本上纯化的多个细胞，所述多个细胞用至少一种能使至少一部分细胞表达的生物活性因子增强 增加量的至少一种软骨形成标记物。

公开(公告)号：US20080166755A9

公开(公告)日：2008-07-10

申请号：US10806915

申请日：2004-03-23

Applicant: Frances Titus ,  Jeffrey Marx ,  Scott Boden ,  Sangwook Yoon ,  Susan Drapeau

Inventor： Frances Titus ,  Jeffrey Marx ,  Scott Boden ,  Sangwook Yoon ,  Susan Drapeau

IPC: C12P21/02 ,  C07K14/475 ,  C07H21/04

CPC classification number: C07K14/005 ,  A61K38/00 ,  C07K14/43581 ,  C07K14/4702 ,  C07K14/475 ,  C07K14/495 ,  C07K14/51 ,  C07K2319/00 ,  C12N2740/16322

Abstract: The invention provides fusion polypeptides comprising protein transduction domains and osteoinductive polypeptides, as well as methods of using such polypeptides to induce osteogenesis and to promote proteoglycan synthesis. The invention also provides osteoinductive peptides which have demonstrated the ability to induce bone formation in vivo.

Abstract translation: 本发明提供了包含蛋白转导结构域和骨诱导多肽的融合多肽，以及使用这些多肽诱导成骨和促进蛋白多糖合成的方法。 本发明还提供已经证明在体内诱导骨形成的能力的骨诱导肽。

公开(公告)号：US20070238992A1

公开(公告)日：2007-10-11

申请号：US11344667

申请日：2006-02-01

Applicant: William Donofrio ,  Jeffrey Nycz ,  Can Cinbis ,  Matthew Morrison ,  Susan Drapeau ,  Qingshan (Sam) Ye

Inventor： William Donofrio ,  Jeffrey Nycz ,  Can Cinbis ,  Matthew Morrison ,  Susan Drapeau ,  Qingshan (Sam) Ye

IPC: A61B8/00

CPC classification number: A61B8/0875 ,  A61B5/076 ,  A61B5/4509 ,  A61B5/4528 ,  A61B5/6882 ,  A61B7/005 ,  A61B7/006 ,  A61B8/4472 ,  A61B8/56 ,  A61B8/565

Abstract: An implantable sensor for detecting changes in tissue density is disclosed. The implantable sensor includes a transducer adapted for detecting indicators of tissue density. The implantable sensor includes memory for storing data corresponding to the tissue density indicators detected by the sensor. A telemetry circuit is configured for transmitting the tissue density data outside of the body.

Abstract translation: 公开了一种用于检测组织密度变化的植入式传感器。 可植入传感器包括适于检测组织密度指标的换能器。 可植入传感器包括用于存储对应于由传感器检测的组织密度指示符的数据的存储器。 遥测电路被配置用于将身体外的组织密度数据传输。

公开(公告)号：US07892532B2

公开(公告)日：2011-02-22

申请号：US10806915

申请日：2004-03-23

Applicant: Frances Louisa Titus ,  Jeffrey C. Marx ,  Scott D. Boden ,  Sangwook T. (Tim) Yoon ,  Susan Drapeau

Inventor： Frances Louisa Titus ,  Jeffrey C. Marx ,  Scott D. Boden ,  Sangwook T. (Tim) Yoon ,  Susan Drapeau

IPC: A01N63/00 ,  C12N5/00 ,  C12N15/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  C07K14/43581 ,  C07K14/4702 ,  C07K14/475 ,  C07K14/495 ,  C07K14/51 ,  C07K2319/00 ,  C12N2740/16322

Abstract: The invention provides fusion polypeptides comprising protein transduction domains and osteoinductive polypeptides, as well as methods of using such polypeptides to induce osteogenesis and to promote proteoglycan synthesis. The invention also provides osteoinductive peptides which have demonstrated the ability to induce bone formation in vivo.

Abstract translation: 本发明提供了包含蛋白转导结构域和骨诱导多肽的融合多肽，以及使用这些多肽诱导成骨和促进蛋白多糖合成的方法。 本发明还提供已经证明在体内诱导骨形成的能力的骨诱导肽。

公开(公告)号：US20070254042A1

公开(公告)日：2007-11-01

申请号：US11415037

申请日：2006-05-01

Applicant: Susan Drapeau ,  Kathy Chamness ,  William McKay

Inventor： Susan Drapeau ,  Kathy Chamness ,  William McKay

IPC: A61K35/37

CPC classification number: A61L27/20 ,  A61F2/28 ,  A61L27/24 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/48

Abstract: Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a polysaccharide. Also described are methods for making and using such medical compositions.

Abstract translation: 描述的是可延展的药物组合物，例如包括与液体载体结合的固体的糊剂或油灰。 固体包括颗粒状胶原和颗粒脱矿质骨基质。 液体载体包括含有多糖的水性介质。 还描述了制备和使用这种医药组合物的方法。

公开(公告)号：US20070253930A1

公开(公告)日：2007-11-01

申请号：US11414689

申请日：2006-04-28

Applicant: Josee Roy ,  Susan Drapeau ,  Jeffrey Marx

Inventor： Josee Roy ,  Susan Drapeau ,  Jeffrey Marx

IPC: A61K38/21 ,  A61K38/18

CPC classification number: A61K38/1825 ,  A61K38/185 ,  A61K38/1858 ,  A61K38/2093 ,  A61K38/212

Abstract: The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.

Abstract translation: 本发明提供了一种通过施用破坏椎间盘中的神经元和/或血管元件（通常是退化的椎间盘）的治疗剂来减轻椎间盘突出症的方法。 磁盘中的神经元元件的破坏包括破坏神经末梢，而不会显着影响神经的中枢体，抑制神经末梢的激活，并抑制神经末梢进入椎间盘的生长。 血管元件的破坏包括使血管延伸部从圆盘缩回，或抑制这种延伸部的形成。 治疗剂可以通过体内泵，推注或贮库局部给药，或者可以全身给药。

公开(公告)号：US20070250114A1

公开(公告)日：2007-10-25

申请号：US11407615

申请日：2006-04-20

Applicant: Susan Drapeau

Inventor： Susan Drapeau

IPC: A61B17/08

CPC classification number: A61F2220/0008

Abstract: A flexible tissue sheath for treating a lacerated fibrous connective tissue is disclosed and can include a hollow body that can define an interior surface and an exterior surface. At least one tissue engagement structure can extend from the hollow body. The tissue engagement structure can engage an end of the lacerated fibrous connective tissue and substantially prevent the end of the lacerated fibrous connective tissue from withdrawing from the hollow body.

Abstract translation: 公开了一种用于处理撕裂的纤维结缔组织的柔性组织护套，并且可以包括可限定内表面和外表面的中空体。 至少一个组织接合结构可以从中空体延伸。 组织接合结构可以接合撕裂的纤维结缔组织的端部并且基本上防止撕裂的纤维结缔组织的端部从中空体抽出。

公开(公告)号：US20070254041A1

公开(公告)日：2007-11-01

申请号：US11415036

申请日：2006-05-01

Applicant: Susan Drapeau ,  Kathy Chamness ,  William McKay

Inventor： Susan Drapeau ,  Kathy Chamness ,  William McKay

IPC: A61K35/37

CPC classification number: A61L27/58 ,  A61L27/3608 ,  A61L27/446 ,  A61L27/46 ,  A61L27/48 ,  A61L27/56

Abstract: Described are medical implant devices that include particulate collagen and particulate demineralized bone matrix. These and potentially other materials are held together in a three-dimensionally stable structure such as a porous, resilient sheet, by an ionically-crosslinked polysaccharide gel. Also described are methods for making and using such medical devices.

Abstract translation: 描述的是包括颗粒状胶原和颗粒脱矿骨基质的医用植入装置。 这些和潜在的其它材料通过离子交联的多糖凝胶一起保持在三维稳定的结构中，例如多孔，弹性片。 还描述了制造和使用这种医疗装置的方法。

公开(公告)号：US20060259006A1

公开(公告)日：2006-11-16

申请号：US11118125

申请日：2005-04-29

Applicant: William McKay ,  Susan Drapeau

Inventor： William McKay ,  Susan Drapeau

IPC: A61M5/00

CPC classification number: A61M5/3148 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00261 ,  A61B2018/00392 ,  A61M5/32 ,  A61M5/3291 ,  A61M5/3298 ,  A61M2005/341

Abstract: Described are novel methods for delivering a medical agent to a plurality of locations within a patient tissue volume such as the interior space of a spinal disc, and also for removing material therefrom during medical agent delivery to enhance the delivery. Also described are medical delivery devices such as needle assemblies configured to facilitate the regional delivery of medical agents to patient tissue.

Abstract translation: 描述了用于将医疗剂递送到患者组织体积（例如脊椎盘的内部空间）内的多个位置的新方法，并且还用于在医疗剂递送期间从其中移除材料以增强输送。 还描述了医疗输送装置，例如构造成便于将医疗药剂区域递送到患者组织的针组件。

公开(公告)号：US20050020506A1

公开(公告)日：2005-01-27

申请号：US10626571

申请日：2003-07-25

Applicant: Susan Drapeau ,  Mark Torrianni ,  Frank Everaerts ,  William McKay

Inventor： Susan Drapeau ,  Mark Torrianni ,  Frank Everaerts ,  William McKay

IPC: A61L24/00 ,  A61L24/10 ,  A61L27/22 ,  A61L27/36 ,  A61K38/39 ,  A61K38/18

CPC classification number: A61L27/3687 ,  A61L24/0005 ,  A61L24/102 ,  A61L27/227 ,  A61L27/3608 ,  A61L27/3645 ,  A61L2430/02

Abstract: A composition comprising a collagen protein and demineralized bone matrix is described wherein the composition is chemically cross-linked with a carbodiimide such as N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC). The crosslinking reaction can be conducted in the presence of N-hydroxysuccinimide (NHS). The collagen can be in a porous matrix or scaffolding. The DBM can be in the form of particles dispersed in the collagen. A method of making the composition is also described wherein a collagen slurry is cast into the desired shape, freeze dried to form a porous scaffolding and infitrated with a solution comprising the cross-linking agent. The composition can be used as an implant for tissue (e.g., soft tissue or bone) engineering.

Abstract translation: 描述了包含胶原蛋白和软化骨基质的组合物，其中组合物与碳二亚胺如N-（3-二甲基氨基丙基）-N-乙基碳二亚胺盐酸盐（EDC）化学交联。 交联反应可以在N-羟基琥珀酰亚胺（NHS）的存在下进行。 胶原蛋白可以在多孔基质或脚手架中。 DBM可以是分散在胶原中的颗粒的形式。 还描述了制备组合物的方法，其中将胶原浆液浇铸成所需形状，冷冻干燥以形成多孔脚手架，并用包含交联剂的溶液进行渗透。 组合物可以用作组织（例如，软组织或骨）工程的植入物。