Invention Application
US20050020506A1 Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use
审中-公开
包含胶原和脱矿质骨基质的交联组合物，制备方法和使用方法
- Patent Title: Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use
- Patent Title (中): 包含胶原和脱矿质骨基质的交联组合物，制备方法和使用方法
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Application No.: US10626571Application Date: 2003-07-25
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Publication No.: US20050020506A1Publication Date: 2005-01-27
- Inventor: Susan Drapeau , Mark Torrianni , Frank Everaerts , William McKay
- Applicant: Susan Drapeau , Mark Torrianni , Frank Everaerts , William McKay
- Main IPC: A61L24/00
- IPC: A61L24/00 ; A61L24/10 ; A61L27/22 ; A61L27/36 ; A61K38/39 ; A61K38/18
Abstract:
A composition comprising a collagen protein and demineralized bone matrix is described wherein the composition is chemically cross-linked with a carbodiimide such as N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC). The crosslinking reaction can be conducted in the presence of N-hydroxysuccinimide (NHS). The collagen can be in a porous matrix or scaffolding. The DBM can be in the form of particles dispersed in the collagen. A method of making the composition is also described wherein a collagen slurry is cast into the desired shape, freeze dried to form a porous scaffolding and infitrated with a solution comprising the cross-linking agent. The composition can be used as an implant for tissue (e.g., soft tissue or bone) engineering.
Information query
