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公开(公告)号：US10159662B2
公开(公告)日：2018-12-25
申请号：US15767508
申请日：2016-12-08
Inventor： Yinong Xie , Zejin You , Zhiwen Deng , Jun Zhu , Ao Wang , Yan Feng , Dong Long , Hong Zeng , Hongmei Song , Qijun Ye , Wei Qi , Donghai Su , Lichun Wang , Jingyi Wang
IPC: A61K31/437 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61K39/00 , A61K31/343 , A61K38/17 , A61K31/519
Abstract: The present invention relates to an azetidine derivative for use as a Janus kinase (JAK) inhibitor, a drug composition comprising same, a preparation method therefor, and a use thereof in the treatment of JAK-related diseases comprising, for example, inflammatory diseases, autoimmune diseases, and cancers.
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公开(公告)号：US10787477B2
公开(公告)日：2020-09-29
申请号：US16343846
申请日：2017-12-15
Inventor： Chengxi Yang , Yufeng Liang , Jiangfeng Zhou , Jianhua Ge , Qiang Tian , Mingliang Zhao , Hong Zeng , Fulu Zhao , Jianfeng Han , Lichun Wang , Jingyi Wang
IPC: C07H19/10 , C07H1/06 , A61P35/00 , A61P31/12 , A61K31/7068
Abstract: The present invention relates to a solid form of a compound of Formula (I), a method for preparing the solid form, a pharmaceutical composition comprising the solid form, and the use of the solid form in the treatment of a disease involving abnormal cell proliferation or a viral infectious disease.
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公开(公告)号：US10696669B2
公开(公告)日：2020-06-30
申请号：US16334237
申请日：2017-11-09
Inventor： Shuai Song , Jiaqiang Cai , Qiang Tian , Hong Zeng , Hongmei Song , Hanwen Deng , Zujian Tang , Xiaofan Duan , Rongrong Long , Yao Liu , Lichun Wang , Jingyi Wang
IPC: C07D417/14 , C07D413/14 , C07D403/14 , C07D401/14 , C07D417/04 , A61P31/16 , A61P31/22 , A61P31/12 , A61K31/506 , A61K9/00
Abstract: The present invention relates to a dihydropyrimidine compound having an antiviral activity, a pharmaceutical composition comprising same, a preparation method therefor and the uses thereof in the prevention or treatment of viral diseases including, but not limited to, Hepatitis A, Hepatitis B, Hepatitis C, influenza, herpes and acquired immunodeficiency syndrome (AIDS).
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公开(公告)号：US11084847B2
公开(公告)日：2021-08-10
申请号：US16321430
申请日：2017-09-22
Inventor： Jiaqiang Cai , Qiang Tian , Mingliang Zhao , Hong Zeng , Hongmei Song , Nan Yu , Hua Deng , Wei Zhong , Long Yang , Lei Wu , Haitao Huang , Yongyong Wu , Donghai Su , Xin Zhou , Yuting Tan , Lichun Wang , Jingyi Wang
Abstract: The invention relates to a polyamide compound and a use thereof. Specifically, the invention relates to a type of polyamide compound (which preferably comprise one or more amide bonds formed by condensation of same or different L-amino acids or D-amino acids), or stereoisomers, crystalline polymorphs, solvates, metabolites, prodrugs or pharmaceutically acceptable salts or esters thereof, or pharmaceutical compositions thereof, as well as a method for preparing the polyamide compound and a use thereof in the prevention or treatment of diseases associated with κ-opioid receptor. The polyamide compound of the invention has excellent κ-opioid receptor agonistic activity and hydrophilicity, thus having a lesser ability of penetrating the blood-brain barrier and a lower capacity for entering the brain. The compound of the invention has higher selectivity for a κ-opioid receptor, lower addictiveness, improved pharmacokinetic properties, and improved safety (lower toxicity and/or fewer side effects), good patient compliance, and/or lesser propensity for developing tolerance, among other excellent medicinal properties.
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公开(公告)号：US20200253971A1
公开(公告)日：2020-08-13
申请号：US16859910
申请日：2020-04-27
Inventor： Shuai Song , Jiaqiang Cai , Qiang Tian , Hong Zeng , Hongmei Song , Hanwen Deng , Zujian Tang , Xiaofan Duan , Rongrong Long , Yao Liu , Lichun Wang , Jingyi Wang
IPC: A61K31/506 , A61K31/5377 , A61P31/16
Abstract: The present invention relates to a method for prophylactically treating or treating a viral disease, comprising administering to a subject in need thereof a dihydropyrimidine compound, and the viral diseases include, but are not limited to, Hepatitis A, Hepatitis B, Hepatitis C, influenza, herpes and acquired immunodeficiency syndrome (AIDS).
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Patent Agency Ranking
公开(公告)号：US11903948B2
公开(公告)日：2024-02-20
申请号：US17169087
申请日：2021-02-05
Inventor： Tongtong Xue , Zhenwei Miao , Jing Wang , Gang Chen , Yan Qing , Tong Zhu , Liang Xiao , Hong Zhang , Qiuyan Yang , Dylan Dalun Deng , Liping Liu , Hong Zeng , Li Yin , Qifeng Shi , Hongmei Song , Xi Zhao , Lichun Wang , Jingyi Wang
CPC classification number: A61K31/536 , A61K47/64 , A61K47/65 , A61K47/6803 , A61K47/6869 , A61P35/00 , C07K16/32 , C07K2317/24
Abstract: Provided is a preparation method of an antibody-drug conjugate represented by Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof, or a solvate of the foregoing,
wherein A, X, Y, L, D and a are as defined herein.-
公开(公告)号：US11266674B2
公开(公告)日：2022-03-08
申请号：US16627897
申请日：2018-08-24
Inventor： Hongmei Song , Hong Zeng , Xiaoda Niu , Ying Wang , Qiang Tian , Daibiao Xiao , Jiaqiang Cai , Lichun Wang , Jingyi Wang
IPC: A61K31/7068 , A61P35/00 , A61K31/435 , C07K16/28
Abstract: A pharmaceutical composition comprising a 4′-thionucleoside phosphamide derivative or a pharmaceutically acceptable salt, ester, hydrate, solvate, and isomer thereof, any crystalline form thereof or racemate, metabolite, or a combination of a mixture thereof with other drugs, and a method and use thereof for disease treatment and/or prevention.
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公开(公告)号：US11045455B2
公开(公告)日：2021-06-29
申请号：US16745206
申请日：2020-01-16
Inventor： Yinong Xie , Zejin You , Zhiwen Deng , Jun Zhu , Ao Wang , Yan Feng , Dong Long , Hong Zeng , Hongmei Song , Qijun Ye , Wei Qi , Donghai Su , Lichun Wang , Jingyi Wang
IPC: A61K31/437 , A61K31/519 , C07D487/04 , C07D471/04 , A61P37/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61K31/343 , A61K38/17 , A61K39/00
Abstract: The present invention relates to an azetidine derivative for use as a Janus kinase (JAK) inhibitor, a drug composition comprising same, a preparation method therefor, and a use thereof in the treatment of JAK-related diseases comprising, for example, inflammatory diseases, autoimmune diseases, and cancers.
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公开(公告)号：US10662214B2
公开(公告)日：2020-05-26
申请号：US15558620
申请日：2016-03-28
Inventor： Hong Ye , Gang Liu , Nan Yu , Hong Zeng , Mingliang Zhao , Yan Qing , Hua Deng , Wenjia Li , Donghong Li , Donghai Su , Wei Zhong , Shaohua Li , Xunwei Wu , Lichun Wang , Jingyi Wang
IPC: A01N43/04 , A61K31/70 , C07H19/10 , C07H19/20 , C07H1/00 , A61K31/7068 , A61K31/7076 , A61K45/06
Abstract: The present invention relates to a novel compound of 4′-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same and an application thereof. Specifically, the present invention relates to a phosphamide derivative of 4′-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same, a use thereof in the preparation of a medicine for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases, and a method of using the same for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases.
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公开(公告)号：US11207420B2
公开(公告)日：2021-12-28
申请号：US16497415
申请日：2018-04-12
Inventor： Jiaqiang Cai , Tongtong Xue , Shuai Song , Jing Wang , Qiang Tian , Liang Xiao , Hanwen Deng , Liping Liu , Zujian Tang , Hong Zeng , Rongrong Long , Hongmei Song , Qiang Zhang , Guoqing Zhong , Dengnian Liu , Haitao Huang , Ruibin Hu , Lichun Wang , Jingyi Wang
Abstract: Provided is a method for modifying a chimeric antigen receptor-modified T cell (CAR-T cell). The method comprises expressing an SCFV-CDS TM-4-1BB-CD3ζ molecule in a T cell. The CAR-T cell prepared using the method can specifically recognize and bind to a tumor cell with elevated expression of a ROBO1 protein, and can be used to prevent and treat a corresponding tumor-related disease.
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