公开(公告)号：US10662214B2

公开(公告)日：2020-05-26

申请号：US15558620

申请日：2016-03-28

Applicant: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Inventor： Hong Ye ,  Gang Liu ,  Nan Yu ,  Hong Zeng ,  Mingliang Zhao ,  Yan Qing ,  Hua Deng ,  Wenjia Li ,  Donghong Li ,  Donghai Su ,  Wei Zhong ,  Shaohua Li ,  Xunwei Wu ,  Lichun Wang ,  Jingyi Wang

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/10 ,  C07H19/20 ,  C07H1/00 ,  A61K31/7068 ,  A61K31/7076 ,  A61K45/06

Abstract: The present invention relates to a novel compound of 4′-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same and an application thereof. Specifically, the present invention relates to a phosphamide derivative of 4′-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same, a use thereof in the preparation of a medicine for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases, and a method of using the same for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases.

公开(公告)号：US20200262860A1

公开(公告)日：2020-08-20

申请号：US16851217

申请日：2020-04-17

Applicant: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Inventor： Hong Ye ,  Gang Liu ,  Nan Yu ,  Hong Zeng ,  Mingliang Zhao ,  Yan Qing ,  Hua Deng ,  Wenjia Li ,  Donghong Li ,  Donghai Su ,  Wei Zhong ,  Shaohua Li ,  Xunwei Wu ,  Lichun Wang ,  Jingyi Wang

IPC: C07H19/10 ,  A61K45/06 ,  A61K31/7076 ,  A61K31/7068 ,  C07H1/00 ,  C07H19/20

Abstract: The present application relates to a method for the prevention or treatment of an abnormal cell proliferative disease in a mammal, wherein the method comprises administering to the mammal an effective amount of a 4′-thionucleoside compound or a pharmaceutically acceptable salt, ester, hydrate, solvate thereof, or racemate thereof, or a mixture thereof.