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公开(公告)号：US11655295B2
公开(公告)日：2023-05-23
申请号：US16963067
申请日：2019-01-03
Inventor： Tongtong Xue , Qiang Li , Liang Xiao , Yuncheng Zheng , Dengnian Liu , Si Chen , Yan Hu , Lichun Wang , Jingyi Wang
IPC: C07K16/28 , A61K39/395 , A61P35/00
CPC classification number: C07K16/2803 , A61K39/39558 , A61P35/00
Abstract: The present invention relates to the field of treatment of diseases and immunology. Specifically, the present invention relates to an anti-LAG-3 antibody or an antigen-binding fragment thereof, nucleic acid molecules for encoding said antibody and fragment, and method for preparing said antibody and fragment. The anti-LAG-3 antibody or the antigen-binding fragment thereof according to the present invention has high specificity and high affinity to LAG-3, can effectively block the binding of LAG-3 to MHC II and/or FGL1, and can inhibit and/or block intracellular signaling mediated by LAG-3 binding to MHC II and/or FGL1. Therefore, the present invention further relates to a pharmaceutical composition comprising the antibody or the antigen-binding fragment thereof, and use of the pharmaceutical composition in the preparation of drugs. The drugs are used for improving the activity of immune cells and enhancing the immune response, or are used for preventing and/or treating tumors, infections or autoimmune diseases.
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公开(公告)号：US20210238282A1
公开(公告)日：2021-08-05
申请号：US17050161
申请日：2019-04-22
Inventor： Qiang Li , Tongtong Xue , Yuncheng Zheng , Liang Xiao , Dengnian Liu , Jianyu Sun , Jiangjiang Hu , Xinlu Ma , Kangyong Zhu , Yuanli Li
Abstract: Provided by the present invention are an antibody against human TIM-3 or an antigen-binding fragment thereof, and further provided are a nucleic acid molecule encoding the antibody, an expression vector for expressing the antibody and a host cell, and a method for producing the antibody. Further provided by the present invention are a pharmaceutical composition comprising the antibody or an antigen-binding fragment of the antibody, and an application of the pharmaceutical composition in the preparation of a medicine, the medicine is used for preventing and/or treating various diseases (including tumors, infectious diseases and autoimmune diseases).
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公开(公告)号：US10465014B2
公开(公告)日：2019-11-05
申请号：US15745230
申请日：2017-03-02
Inventor： Baiyong Li , Tongtong Xue , Yu Xia , Zhongmin Maxwell Wang , Liang Xiao , Lichun Wang , Jingyi Wang
IPC: C07K16/46 , A61K39/395 , C07K14/705 , C07K16/28 , A61K47/68 , A61P35/02
Abstract: The present invention belongs to the field of tumor therapy and molecular immunology, and relates to a PDL-1 antibody, a pharmaceutical composition thereof and use thereof. In particular, the present invention relates to a PDL-1 monoclonal antibody or an antigen-binding fragment thereof, wherein the monoclonal antibody has a heavy chain variable region comprising CDRs as set forth in SEQ ID NOs: 15-17; and/or has a light chain variable region comprising CDRs as set forth in SEQ ID NOs: 18-20. The monoclonal antibody of the present invention can bind to PDL-1 specifically, and specifically remove immunosuppressive function of PDL-1 and activate T lymphocytes.
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公开(公告)号：US20220144847A1
公开(公告)日：2022-05-12
申请号：US17431930
申请日：2020-02-11
Inventor： Zhonghui Chen , Shuangshuang Duan , Guiying Li , Runfeng Han , Qizheng Sun , Liandong Jing , Xiaojun Han , Qiang Tian , Hongmei Song , Tongtong Xue , Jingyi Wang
IPC: C07D487/08 , A61P35/00
Abstract: The present disclosure relates to a heterocyclic compound, a pharmaceutical composition comprising same, a preparation method therefor, and a use thereof. Specifically, the compound of the present invention is represented by formula (I), and used for preventing or treating a disease or condition related to RET activity.
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公开(公告)号：US20200010570A1
公开(公告)日：2020-01-09
申请号：US16516991
申请日：2019-07-19
Inventor： Baiyong Li , Tongtong Xue , Yu Xia , Zhongmin Maxwell Wang , Liang Xiao , Lichun Wang , Jingyi Wang
Abstract: The present invention belongs to the field of tumor therapy and molecular immunology, and relates to a PDL-1 antibody, a pharmaceutical composition thereof and use thereof. In particular, the present invention relates to a PDL-1 monoclonal antibody or an antigen-binding fragment thereof, wherein the monoclonal antibody has a heavy chain variable region comprising CDRs as set forth in SEQ ID NOs: 15-17; and/or has a light chain variable region comprising CDRs as set forth in SEQ ID NOs: 18-20. The monoclonal antibody of the present invention can bind to PDL-1 specifically, and specifically remove immunosuppressive function of PDL-1 and activate T lymphocytes.
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Patent Agency Ranking
公开(公告)号：US12150944B2
公开(公告)日：2024-11-26
申请号：US16979251
申请日：2019-04-30
Inventor： Hongmei Song , Xiaoxi Yuan , Jing Wang , Liang Xiao , Tongtong Xue , Ping Liu , Lichun Wang , Jingyi Wang
IPC: A61K47/68 , A61K9/00 , A61K31/337 , A61K31/555 , A61P35/00 , C07K16/32
Abstract: Disclosed in the present invention is the use of an anti-HER2 antibody-drug conjugate in cancer treatment. Further provided in the present invention is the use of a pharmaceutically acceptable salt, stereoisomer, or metabolite thereof, or a solvate of each of the foregoing in the manufacture of a medicament for the prophylaxis and/or treatment of a cancer insensitive or irresponsive to a treatment with a HER2-targeting agent.
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公开(公告)号：US11970506B2
公开(公告)日：2024-04-30
申请号：US16758980
申请日：2018-12-10
Inventor： Jiaqiang Cai , Shuai Song , Tongtong Xue , Liang Xiao , Hanwen Deng , Qiang Tian , Guoqing Zhong , Lichun Wang , Jingyi Wang
IPC: C07D491/22 , A61K45/06 , A61K47/68 , A61P35/00 , C07D401/14 , C07D403/12 , C07D403/14 , C07K5/062 , C07K16/30 , C07K16/32
CPC classification number: C07D491/22 , A61K47/6803 , A61K47/6851 , A61K47/6885 , A61P35/00 , C07D401/14 , C07D403/12 , C07D403/14 , C07K5/06052 , C07K16/30 , C07K16/32 , A61K45/06
Abstract: Provided herein are bioactive molecule conjugates, preparation methods and use thereof, particularly bioactive molecule conjugates (such as antibody-drug conjugates and small molecule drug conjugates) obtained by improved coupling of a drug and a targeting moiety, as well as their preparation method and use for the treatment of a disease associated with an abnormal cell activity.
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公开(公告)号：US11903948B2
公开(公告)日：2024-02-20
申请号：US17169087
申请日：2021-02-05
Inventor： Tongtong Xue , Zhenwei Miao , Jing Wang , Gang Chen , Yan Qing , Tong Zhu , Liang Xiao , Hong Zhang , Qiuyan Yang , Dylan Dalun Deng , Liping Liu , Hong Zeng , Li Yin , Qifeng Shi , Hongmei Song , Xi Zhao , Lichun Wang , Jingyi Wang
CPC classification number: A61K31/536 , A61K47/64 , A61K47/65 , A61K47/6803 , A61K47/6869 , A61P35/00 , C07K16/32 , C07K2317/24
Abstract: Provided is a preparation method of an antibody-drug conjugate represented by Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof, or a solvate of the foregoing,
wherein A, X, Y, L, D and a are as defined herein.-
公开(公告)号：US11421029B2
公开(公告)日：2022-08-23
申请号：US16624408
申请日：2018-08-17
Inventor： Tongtong Xue , Liang Xiao , Dengnian Liu , Hu Long , Jiangjiang Hu , Yamin Cui , Xiaoxi Yuan , Lichun Wang , Jingyi Wang
Abstract: Provided are a recombinant bispecific antibody against CTLA-4 and PDL-1, a nucleic acid molecule for encoding the antibody, a vector and a host cell comprising the nucleic acid molecule, and a method for preparing the antibody. Also provided are a pharmaceutical composition comprising the bispecific antibody, and usage of the bispecific antibody in preparation of the pharmaceutical composition.
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公开(公告)号：US20230295174A1
公开(公告)日：2023-09-21
申请号：US18017104
申请日：2021-07-23
Inventor： Zheng Gong , Hongming Li , Shidong Yi , Long Li , Tianming Wang , Pingyun Chen , Chengxi Yang , Tao Wang , Yaoyao Song , Jiangfeng Zhou , Yufeng Liang , Zhonghui Chen , Qiang Tian , Hongmei Song , Tongtong Xue , Jingyi Wang
IPC: C07D487/08
CPC classification number: C07D487/08 , C07B2200/13
Abstract: Provided are a salt and a crystal form of a pyrimidine compound, and preparation methods therefor. Specifically, provided are a salt and a crystal form of a compound I, including a crystal form of the salt, and preparation methods therefor.
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