公开(公告)号：US11541049B2

公开(公告)日：2023-01-03

申请号：US16965450

申请日：2019-03-18

Applicant: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

Inventor： Yongyong Wu ,  Jiaqiang Cai ,  Guangchao Zhang ,  Shuangshuang Duan ,  Chaolei Wang ,  Lichun Wang ,  Jingyi Wang

IPC: C07D403/14 ,  A61K31/496 ,  A61P7/02 ,  A61K31/4725 ,  A61K45/06 ,  C07D401/14 ,  C07D413/14 ,  C07D401/10

Abstract: Provided are tetrahydroisoquinoline derivatives, the preparation and use thereof. More specifically, provided are the tetrahydroisoquinoline derivatives or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, polymorph, solvate, isotopically labeled compound, metabolite or prodrug thereof. Further provided are a preparation process of the compound, the intermediates, a pharmaceutical composition comprising the compound and the use thereof in the treatment or prevention of a thromboembolic disorder.

公开(公告)号：US20220144847A1

公开(公告)日：2022-05-12

申请号：US17431930

申请日：2020-02-11

Applicant: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Inventor： Zhonghui Chen ,  Shuangshuang Duan ,  Guiying Li ,  Runfeng Han ,  Qizheng Sun ,  Liandong Jing ,  Xiaojun Han ,  Qiang Tian ,  Hongmei Song ,  Tongtong Xue ,  Jingyi Wang

IPC: C07D487/08 ,  A61P35/00

Abstract: The present disclosure relates to a heterocyclic compound, a pharmaceutical composition comprising same, a preparation method therefor, and a use thereof. Specifically, the compound of the present invention is represented by formula (I), and used for preventing or treating a disease or condition related to RET activity.