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公开(公告)号：US11434235B2
公开(公告)日：2022-09-06
申请号：US16981430
申请日：2019-05-06
Inventor： Tianming Wang , Chengxi Yang , Jiaqiang Cai , Wei Liu , Baolei Zhang , Qiang Tian , Shuai Song , Hao Hu , Weibiao Han , Youqiang Li , Xing Chen , Lichun Wang , Jingyi Wang
IPC: C07D417/14 , A61K45/06
Abstract: Disclosed are a solid form of (E)-3-((R)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)acrylic acid, a preparation method therefor, a pharmaceutical composition comprising same, and the use thereof in the preparation of drugs for preventing or treating viral diseases.
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公开(公告)号：US20230295174A1
公开(公告)日：2023-09-21
申请号：US18017104
申请日：2021-07-23
Inventor： Zheng Gong , Hongming Li , Shidong Yi , Long Li , Tianming Wang , Pingyun Chen , Chengxi Yang , Tao Wang , Yaoyao Song , Jiangfeng Zhou , Yufeng Liang , Zhonghui Chen , Qiang Tian , Hongmei Song , Tongtong Xue , Jingyi Wang
IPC: C07D487/08
CPC classification number: C07D487/08 , C07B2200/13
Abstract: Provided are a salt and a crystal form of a pyrimidine compound, and preparation methods therefor. Specifically, provided are a salt and a crystal form of a compound I, including a crystal form of the salt, and preparation methods therefor.
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公开(公告)号：US11186599B2
公开(公告)日：2021-11-30
申请号：US17047000
申请日：2019-06-03
Inventor： Qiang Tian , Tianming Wang , Wei Liu , Baolei Zhang , Mingliang Zhao , Yufeng Liang , Jiaqiang Cai , Lichun Wang , Jingyi Wang
IPC: C07F9/6561 , C07F9/02
Abstract: The present invention relates to compounds represented by formula (I) and formula (II) and a chiral synthesis and chiral isolation method therefor, further relating to a salt and crystal form of the compound represented by formula (I), a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the preparation of a medicament used for the treatment of a viral infectious disease such as hepatitis B.
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