公开(公告)号：US12150944B2

公开(公告)日：2024-11-26

申请号：US16979251

申请日：2019-04-30

Applicant: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

Inventor： Hongmei Song ,  Xiaoxi Yuan ,  Jing Wang ,  Liang Xiao ,  Tongtong Xue ,  Ping Liu ,  Lichun Wang ,  Jingyi Wang

IPC: A61K47/68 ,  A61K9/00 ,  A61K31/337 ,  A61K31/555 ,  A61P35/00 ,  C07K16/32

Abstract: Disclosed in the present invention is the use of an anti-HER2 antibody-drug conjugate in cancer treatment. Further provided in the present invention is the use of a pharmaceutically acceptable salt, stereoisomer, or metabolite thereof, or a solvate of each of the foregoing in the manufacture of a medicament for the prophylaxis and/or treatment of a cancer insensitive or irresponsive to a treatment with a HER2-targeting agent.