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公开(公告)号：US11084847B2
公开(公告)日：2021-08-10
申请号：US16321430
申请日：2017-09-22
Inventor： Jiaqiang Cai , Qiang Tian , Mingliang Zhao , Hong Zeng , Hongmei Song , Nan Yu , Hua Deng , Wei Zhong , Long Yang , Lei Wu , Haitao Huang , Yongyong Wu , Donghai Su , Xin Zhou , Yuting Tan , Lichun Wang , Jingyi Wang
Abstract: The invention relates to a polyamide compound and a use thereof. Specifically, the invention relates to a type of polyamide compound (which preferably comprise one or more amide bonds formed by condensation of same or different L-amino acids or D-amino acids), or stereoisomers, crystalline polymorphs, solvates, metabolites, prodrugs or pharmaceutically acceptable salts or esters thereof, or pharmaceutical compositions thereof, as well as a method for preparing the polyamide compound and a use thereof in the prevention or treatment of diseases associated with κ-opioid receptor. The polyamide compound of the invention has excellent κ-opioid receptor agonistic activity and hydrophilicity, thus having a lesser ability of penetrating the blood-brain barrier and a lower capacity for entering the brain. The compound of the invention has higher selectivity for a κ-opioid receptor, lower addictiveness, improved pharmacokinetic properties, and improved safety (lower toxicity and/or fewer side effects), good patient compliance, and/or lesser propensity for developing tolerance, among other excellent medicinal properties.
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公开(公告)号：US10662214B2
公开(公告)日：2020-05-26
申请号：US15558620
申请日：2016-03-28
Inventor： Hong Ye , Gang Liu , Nan Yu , Hong Zeng , Mingliang Zhao , Yan Qing , Hua Deng , Wenjia Li , Donghong Li , Donghai Su , Wei Zhong , Shaohua Li , Xunwei Wu , Lichun Wang , Jingyi Wang
IPC: A01N43/04 , A61K31/70 , C07H19/10 , C07H19/20 , C07H1/00 , A61K31/7068 , A61K31/7076 , A61K45/06
Abstract: The present invention relates to a novel compound of 4′-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same and an application thereof. Specifically, the present invention relates to a phosphamide derivative of 4′-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same, a use thereof in the preparation of a medicine for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases, and a method of using the same for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases.
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公开(公告)号：US10899786B2
公开(公告)日：2021-01-26
申请号：US16344317
申请日：2017-12-19
Inventor： Jiaqiang Cai , Shuai Song , Qiang Tian , Yitao Zhang , Haitao Huang , Guoqing Zhong , Wei Zhong , Yongjia Hao , Mingliang Zhao , Hong Zeng , Hongmei Song , Xin Zhou , Yao Liu , Yuting Tan , Lichun Wang , Jingyi Wang
Abstract: Provided in the present invention are a compound of Formula (I), a pharmaceutical composition comprising the same, a method for preparing the same, and use thereof as a NS5B polymerase inhibitor, a DNA polymerase inhibitor or a reverse transcriptase inhibitor for the prevention or treatment of viral diseases or cancers.
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公开(公告)号：US20200262860A1
公开(公告)日：2020-08-20
申请号：US16851217
申请日：2020-04-17
Inventor： Hong Ye , Gang Liu , Nan Yu , Hong Zeng , Mingliang Zhao , Yan Qing , Hua Deng , Wenjia Li , Donghong Li , Donghai Su , Wei Zhong , Shaohua Li , Xunwei Wu , Lichun Wang , Jingyi Wang
IPC: C07H19/10 , A61K45/06 , A61K31/7076 , A61K31/7068 , C07H1/00 , C07H19/20
Abstract: The present application relates to a method for the prevention or treatment of an abnormal cell proliferative disease in a mammal, wherein the method comprises administering to the mammal an effective amount of a 4′-thionucleoside compound or a pharmaceutically acceptable salt, ester, hydrate, solvate thereof, or racemate thereof, or a mixture thereof.
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