公开(公告)号：US09517988B2

公开(公告)日：2016-12-13

申请号：US14936310

申请日：2015-11-09

Applicant: Sichuan Haisco Pharmaceutical Co., Ltd.

Inventor： Linlin Qin ,  Fangqiong Li ,  Shixu Yi ,  Huadong Luo ,  Xinfeng Luo ,  Songlin Wan ,  Lei Ren ,  Guoliang Liu ,  Yonggang Wei ,  Jianyu Liu ,  Peng Cho Tang

IPC: C07C43/00 ,  C07C39/00 ,  C07D213/00 ,  C07F9/00 ,  C07C39/17 ,  C07C39/42 ,  C07C69/96 ,  C07C43/21 ,  C07C43/23 ,  C07C69/157 ,  C07C69/24 ,  C07C69/82 ,  C07D207/16 ,  C07F9/6574 ,  C07F9/09 ,  C07F9/12 ,  C07F9/24 ,  C07D213/80 ,  C07C271/22 ,  C07C271/44 ,  C07C229/08 ,  C07C229/36 ,  C07C37/00 ,  C07C37/62 ,  C07C41/18 ,  C07C67/10 ,  C07C68/00 ,  C07C69/07 ,  C07C69/78 ,  C07C227/04 ,  C07C269/00 ,  C07D213/803 ,  C07F9/06

CPC classification number: C07C39/17 ,  C07C37/00 ,  C07C37/001 ,  C07C37/62 ,  C07C39/42 ,  C07C41/18 ,  C07C43/21 ,  C07C43/23 ,  C07C67/10 ,  C07C68/00 ,  C07C69/07 ,  C07C69/157 ,  C07C69/24 ,  C07C69/78 ,  C07C69/82 ,  C07C69/96 ,  C07C227/04 ,  C07C229/08 ,  C07C229/36 ,  C07C269/00 ,  C07C271/22 ,  C07C271/44 ,  C07C2601/02 ,  C07C2601/04 ,  C07D207/16 ,  C07D213/80 ,  C07D213/803 ,  C07F9/06 ,  C07F9/091 ,  C07F9/094 ,  C07F9/12 ,  C07F9/242 ,  C07F9/2458 ,  C07F9/65744

Abstract: The present invention relates to a phenol derivative and the preparation method and use in medicine thereof, and particular to a phenol derivative represented by general formula (A) or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically acceptable salt or a cocrystal thereof, a preparation method thereof, a pharmaceutical composition comprising the same, and use of the compound or composition of the present invention in the field of the central nervous system; wherein the definitions of substituents in general formula (A) are the same as those in the Description.

Abstract translation: 本发明涉及一种酚衍生物及其药物的制备方法和用途，特别涉及通式（A）表示的苯酚衍生物或立体异构体，溶剂合物，代谢物，前药，药学上可接受的盐或 其共结晶体，其制备方法，包含其的药物组合物，以及本发明化合物或组合物在中枢神经系统领域中的用途; 其中通式（A）中的取代基的定义与说明书中的相同。

公开(公告)号：US20170290781A1

公开(公告)日：2017-10-12

申请号：US15508677

申请日：2015-08-28

Applicant: Sichuan Haisco Pharmaceutical Co., Ltd.

Inventor： Yi MO ,  Fangqiong Li ,  Jianyu Liu ,  Yan Yu ,  Honghu Li ,  Hong Mu ,  Yuquan Zhang ,  Qingyang YU ,  Fujun Cheng ,  Pangke Yan ,  Ziwei Zhao ,  Linlin Qin

IPC: A61K31/05 ,  A61K9/00 ,  A61K9/08 ,  A61K47/44 ,  A61K47/24 ,  A61J1/18 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26 ,  A61K31/661 ,  A61K47/02

Abstract: The present disclosure provides a pharmaceutical preparation of a compound of formula (I) or a stereoisomer, pharmaceutically acceptable salt, or prodrug thereof. The present disclosure further provides a method for general anesthesia or sedation for mammals. Also provided are kits and manufactured products of the medicament and the pharmaceutical composition and a method for using the medicament and the pharmaceutical composition.

公开(公告)号：US10729666B2

公开(公告)日：2020-08-04

申请号：US15508677

申请日：2015-08-28

Applicant: Sichuan Haisco Pharmaceutical Co., Ltd.

Inventor： Yi Mo ,  Fangqiong Li ,  Jianyu Liu ,  Yan Yu ,  Honghu Li ,  Hong Mu ,  Yuquan Zhang ,  Qingyang Yu ,  Fujun Cheng ,  Pangke Yan ,  Ziwei Zhao ,  Linlin Qin

IPC: A61K31/05 ,  A61P25/20 ,  A61K9/08 ,  A61K9/107 ,  A61K9/19 ,  A61P1/08 ,  A61P25/08 ,  A61K45/06 ,  A61P25/24 ,  A61P25/22 ,  A61P25/18 ,  A61P25/06 ,  C07F9/09 ,  A61K31/661 ,  A61J1/18 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/24 ,  A61K47/26 ,  A61K47/44

Abstract: The present disclosure provides a pharmaceutical preparation of a compound of formula (I) or a stereoisomer, pharmaceutically acceptable salt, or prodrug thereof. The present disclosure further provides a method for general anesthesia or sedation for mammals. Also provided are kits and manufactured products of the medicament and the pharmaceutical composition and a method for using the medicament and the pharmaceutical composition.