Biomarkers of metabolic responses to hepatic drugs
    10.
    发明授权
    Biomarkers of metabolic responses to hepatic drugs 有权
    对肝脏药物的代谢反应的生物标记物

    公开(公告)号:US07807138B2

    公开(公告)日:2010-10-05

    申请号:US11840466

    申请日:2007-08-17

    IPC分类号: A61N49/00

    CPC分类号: G01N33/5014

    摘要: Methods for the measurement and prediction of response to hepatotoxicants and carcinogens through the detection of metabolites in a mammal are provided. The metabolites can be used as biomarkers, including efficacy biomarkers, surrogate biomarkers, and toxicity biomarkers. The methods find use for early prediction of toxicity, target identification/validation, and monitoring of drug efficacy.

    摘要翻译: 提供了通过检测哺乳动物代谢物测量和预测对肝毒素和致癌物质的反应的方法。 代谢物可用作生物标志物,包括功效生物标志物,替代生物标志物和毒性生物标志物。 该方法用于早期预测毒性,靶标鉴定/验证和药物疗效监测。