知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

22 records (took 0.024 seconds)

    Biomarkers of metabolic responses to hepatic drugs
    1.
    发明授权
    Biomarkers of metabolic responses to hepatic drugs 有权
    对肝脏药物的代谢反应的生物标记物

    公开(公告)号：US07807138B2

    公开(公告)日：2010-10-05

    申请号：US11840466

    申请日：2007-08-17

    Applicant: Alvin Berger ,  Imran A. Shah

    Inventor： Alvin Berger ,  Imran A. Shah

    IPC: A61N49/00

    CPC classification number: G01N33/5014

    Abstract: Methods for the measurement and prediction of response to hepatotoxicants and carcinogens through the detection of metabolites in a mammal are provided. The metabolites can be used as biomarkers, including efficacy biomarkers, surrogate biomarkers, and toxicity biomarkers. The methods find use for early prediction of toxicity, target identification/validation, and monitoring of drug efficacy.

    Abstract translation: 提供了通过检测哺乳动物代谢物测量和预测对肝毒素和致癌物质的反应的方法。 代谢物可用作生物标志物，包括功效生物标志物，替代生物标志物和毒性生物标志物。 该方法用于早期预测毒性，靶标鉴定/验证和药物疗效监测。

    Inertial torque reaction management with selectively engageable counter rotating component
    5.
    发明授权
    Inertial torque reaction management with selectively engageable counter rotating component 有权
    惯性转矩反应管理，可选择性地接合反向旋转部件

    公开(公告)号：US07178497B2

    公开(公告)日：2007-02-20

    申请号：US10908393

    申请日：2005-05-10

    Applicant: Alvin Berger ,  Vince Solferino

    Inventor： Alvin Berger ,  Vince Solferino

    IPC: F02B75/00

    CPC classification number: B60W30/20 ,  B60W10/06 ,  B60W10/08 ,  B60W10/30

    Abstract: A system and method for managing inertial torque reaction of a powertrain include a selectively engageable counter-rotating component to reduce or eliminate torque reaction on stationary powertrain structure. Selectively engageable counter-rotating inertia may be provided by a simple inertial mass or by an electrical machine functioning as an integral starter/generator (ISG) to provide vehicle launch assist, regenerative braking of the vehicle, and engine cranking. Embodiments include gear-driven, chain-driven, and belt-driven counter-rotating inertias selectively coupled for counter-rotation relative to the crankshaft by a clutch, a belt-driven pulley assembly, or chain-driven intermediate shaft assembly with a hydraulically actuated coupling pin.

    Abstract translation: 用于管理动力系的惯性力矩反作用的系统和方法包括可选择性地接合的反向旋转部件，以减少或消除固定动力系结构上的扭矩反作用。 可以通过简单的惯性质量或用作整体式起动/发电机（ISG）的电机来提供选择性地接合的反向旋转惯性，以提供车辆启动辅助，车辆的再生制动和发动机起动。 实施例包括齿轮驱动，链条驱动和皮带驱动的反向旋转惯性，其通过离合器，皮带从动皮带轮组件或链驱动的中间轴组件选择性地联接以相对于曲轴进行反向转动，所述中间轴组件具有液压致动 连接销。

    Nutritional composition
    8.
    发明授权
    Nutritional composition 失效
    营养成分

    公开(公告)号：US08323680B1

    公开(公告)日：2012-12-04

    申请号：US10089658

    申请日：2000-09-14

    Applicant: Alvin Berger ,  Gayle Crozier

    Inventor： Alvin Berger ,  Gayle Crozier

    IPC: A61K47/00

    CPC classification number: A61K31/231 ,  A23L33/115 ,  A23L33/12 ,  A61K31/00 ,  A61K31/16 ,  A61K31/164 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  A61K31/23

    Abstract: A nutritional or therapeutic composition for oral administration which comprises a naturally occurring precursor that is metabolised to a compound having anandamide activity for use as a medicament or nutritive product. In addition the invention includes a method of production of the composition, use of the composition in the manufacture of a nutritional composition for the treatment or prevention of a behavioral disorder; and a method of treatment or prevention of a behavioral disorder which comprises administering an effective amount of the composition. In a preferred embodiment the composition comprises a triacylglycerol having palmitate and arachidonate attached to its backbone wherein arachidonate is at the sn-1 and sn-2 positions.

    Abstract translation: 一种用于口服给药的营养或治疗组合物，其包含天然存在的前体，其被代谢为具有用于药物或营养产品的具有酰胺活性的化合物。 此外，本发明包括生产该组合物的方法，该组合物在制备用于治疗或预防行为障碍的营养组合物中的用途; 以及治疗或预防行为障碍的方法，其包括施用有效量的组合物。 在优选的实施方案中，组合物包含具有棕榈酸酯和花生四烯酸连接到其主链的三酰基甘油，其中花生四烯酸酯处于sn-1和sn-2位置。

Patent Agency Ranking