公开(公告)号：US20100279956A1

公开(公告)日：2010-11-04

申请号：US12771729

申请日：2010-04-30

Applicant: Bruce J. MC CREEDY, JR. ,  Alvin Berger ,  YunFu Hu ,  Satish C. Kalhan

Inventor： Bruce J. MC CREEDY, JR. ,  Alvin Berger ,  YunFu Hu ,  Satish C. Kalhan

IPC: A61K31/7004 ,  C12Q1/00 ,  G01N33/53 ,  C12Q1/02 ,  G01N33/00 ,  G01N30/02 ,  A61K31/66 ,  A61K31/60 ,  A61K31/56 ,  A61K31/415 ,  A61K31/195

CPC classification number: G01N33/6893 ,  G01N2500/00 ,  G01N2570/00 ,  G01N2800/085 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  H01J49/0027 ,  Y10T436/143333 ,  Y10T436/163333 ,  Y10T436/200833

Abstract: The present invention provides various biomarkers of fatty liver disease, including steatosis and steatohepatitis. The present invention also provides various methods of using the biomarkers, including methods for diagnosis of fatty liver disease, methods of determining predisposition to fatty liver disease, methods of monitoring progression/regression of fatty liver disease, methods of assessing efficacy of compositions for treating fatty liver disease, methods of screening compositions for activity in modulating biomarkers of fatty liver disease, methods of treating fatty liver disease, as well as other methods based on biomarkers of fatty liver disease.

Abstract translation: 本发明提供脂肪肝疾病的多种生物标志物，包括脂肪变性和脂肪性肝炎。 本发明还提供了使用生物标志物的各种方法，包括用于诊断脂肪肝疾病的方法，确定脂肪肝疾病倾向的方法，监测脂肪肝疾病进展/消退的方法，评价组合物治疗脂肪的功效的方法 肝脏疾病，筛选脂肪肝疾病生物标志物活性组合物的方法，脂肪肝疾病治疗方法以及基于脂肪肝疾病生物标志物的其他方法。