公开(公告)号：US08323680B1

公开(公告)日：2012-12-04

申请号：US10089658

申请日：2000-09-14

Applicant: Alvin Berger ,  Gayle Crozier

Inventor： Alvin Berger ,  Gayle Crozier

IPC: A61K47/00

CPC classification number: A61K31/231 ,  A23L33/115 ,  A23L33/12 ,  A61K31/00 ,  A61K31/16 ,  A61K31/164 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  A61K31/23

Abstract: A nutritional or therapeutic composition for oral administration which comprises a naturally occurring precursor that is metabolised to a compound having anandamide activity for use as a medicament or nutritive product. In addition the invention includes a method of production of the composition, use of the composition in the manufacture of a nutritional composition for the treatment or prevention of a behavioral disorder; and a method of treatment or prevention of a behavioral disorder which comprises administering an effective amount of the composition. In a preferred embodiment the composition comprises a triacylglycerol having palmitate and arachidonate attached to its backbone wherein arachidonate is at the sn-1 and sn-2 positions.

Abstract translation: 一种用于口服给药的营养或治疗组合物，其包含天然存在的前体，其被代谢为具有用于药物或营养产品的具有酰胺活性的化合物。 此外，本发明包括生产该组合物的方法，该组合物在制备用于治疗或预防行为障碍的营养组合物中的用途; 以及治疗或预防行为障碍的方法，其包括施用有效量的组合物。 在优选的实施方案中，组合物包含具有棕榈酸酯和花生四烯酸连接到其主链的三酰基甘油，其中花生四烯酸酯处于sn-1和sn-2位置。