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    Peptide particle formulation
    1.
    发明授权
    Peptide particle formulation 有权
    肽颗粒配方

    公开(公告)号：US09408906B2

    公开(公告)日：2016-08-09

    申请号：US13153826

    申请日：2011-06-06

    申请人： Reid M. Rubsamen ,  David Earl Heckerman

    发明人： Reid M. Rubsamen ,  David Earl Heckerman

    IPC分类号： A61K39/00 ,  A61K9/14 ,  A61K39/39 ,  A61K9/16

    CPC分类号： A61K39/385 ,  A61K9/1647 ,  A61K9/5153 ,  A61K39/245 ,  A61K39/39 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/57 ,  A61K2039/6093 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/16134

    摘要： A composition as disclosed is comprised of a plurality of groups of particles. The particles are comprised of a biocompatible polymer which maybe a co-polymer such as PLGA combined with a peptide of a sequence of interest, e.g. a sequence which corresponds to a sequence presented on a surface of a cell infected with a virus. A plurality of different groups of particles are provided in the formulation wherein the particles within any single group include peptides of identical amino acid sequence. The particles are sized such that they are sufficiently large so as to prevent more than the contents of a single particle from being presented to a single immune system cell.

    摘要翻译： 所公开的组合物由多组颗粒组成。 颗粒由生物相容性聚合物组成，其可以是共聚物，例如与感兴趣的序列的肽结合的PLGA，例如。 对应于在感染病毒的细胞表面上呈现的序列的序列。 在制剂中提供多个不同组的颗粒，其中任何单一组中的颗粒包括相同氨基酸序列的肽。 这些颗粒的尺寸使得它们足够大，以便防止单个颗粒的含量超过单个免疫系统细胞。

    Insulin delivery enhanced by coached breathing
    4.
    发明授权
    Insulin delivery enhanced by coached breathing 失效
    通过辅导呼吸增强胰岛素输送

    公开(公告)号：US06408854B1

    公开(公告)日：2002-06-25

    申请号：US09553693

    申请日：2000-04-21

    申请人： Igor Gonda ,  Reid M. Rubsamen

    发明人： Igor Gonda ,  Reid M. Rubsamen

    IPC分类号： A61B1900

    CPC分类号： A61M15/00 ,  A61J7/0418 ,  A61J7/0427 ,  A61J7/0445 ,  A61K9/007 ,  A61K9/0073 ,  A61K38/28 ,  A61M11/001 ,  A61M15/0031 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0055 ,  A61M15/0066 ,  A61M15/008 ,  A61M15/0085 ,  A61M15/009 ,  A61M16/142 ,  A61M2016/0021 ,  A61M2016/0036 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2205/50 ,  A61M2205/8206

    摘要： The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of an inhale-exhale breathing maneuver. Particles of insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. The rate of absorption is enhanced by instructing the patient to inhale maximally and thereafter exhale maximally. This maneuver causes a spike in the rate at which insulin enters the circulatory system thereby increasing the rate at which glucose is removed from the circulatory system. The insulinmay be a dry powder but is preferably in a liquid formulation delivered to the patient from a hand-held, self-contained device which automatically releases an aerosolized burst of formulation. The device includes a sensor which is preferably electronic which measures inspiratory flow and volume which measurement can be used to control the point of drug release. The sensor can also assist the patient in the inhale-exhale maneuver.

    摘要翻译： 可以通过以下方法减少或消除对通过注射递送胰岛素的需要：将雾化的胰岛素制剂输送到患者的肺中，并且通过使用吸入呼气来增加胰岛素被吸收到血液中的速率 呼吸机动 输送到肺组织表面的胰岛素颗粒将被吸收到循环系统中。 通过指导患者最大限度吸入，然后最大程度地呼气，提高吸收率。 这种操作导致胰​​岛素进入循环系统的速率的峰值，从而增加从循环系统中除去葡萄糖的速率。 胰岛素可以是干粉，但是优选地是从手持式独立装置输送到患者的液体制剂，其自动释放雾化的制剂爆发。 该装置包括传感器，其优选是电子的，其测量吸气流量和体积，该测量可用于控制药物释放点。 传感器还可以帮助患者进行吸气呼气操作。

    Systems for the intrapulmonary delivery of aerosolized aqueous formulations
    5.
    发明授权
    Systems for the intrapulmonary delivery of aerosolized aqueous formulations 失效
    用于肺内递送雾化水性制剂的系统

    公开(公告)号：US6123068A

    公开(公告)日：2000-09-26

    申请号：US65753

    申请日：1998-04-24

    申请人： Lester John Lloyd ,  Peter M. Lloyd ,  Reid M. Rubsamen ,  Jeffrey Arthur Schuster

    发明人： Lester John Lloyd ,  Peter M. Lloyd ,  Reid M. Rubsamen ,  Jeffrey Arthur Schuster

    IPC分类号： B65D81/24 ,  A61J1/03 ,  A61J1/14 ,  A61J3/00 ,  A61J7/04 ,  A61K51/12 ,  A61M11/00 ,  A61M13/00 ,  A61M15/00 ,  A61M16/00 ,  B65D81/32 ,  B65D83/00

    CPC分类号： A61K51/1206 ,  A61M15/00 ,  A61M15/001 ,  A61M15/0031 ,  A61M15/0043 ,  A61M15/0051 ,  A61M15/0055 ,  A61M15/008 ,  B65D81/32 ,  A61J1/035 ,  A61J7/0418 ,  A61M11/002 ,  A61M15/0085 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2205/8206 ,  A61M2230/40

    摘要： A disposable package, tape, and cassette are provided which makes it possible to hold and disperse therefrom liquid, flowable formulations including aqueous formulations (solutions or dispersions with particles less than 0.25 microns in diameter) of a pharmaceutically active drug. In one embodiment formulation is packaged in individual dosage unit containers which containers are preferably interconnected. The package is designed to be integrated into a cassette which can be loaded into a dispersing device capable of individually opening dosage unit containers and aerosolizing the contents through a porous membrane, into a mouth piece on the cassette, for delivery to a patient. In addition to and alongside of each porous membrane, the package may include one or more openings through which air is forced in order to aid in avoiding the accumulation of aerosolized particles. The package may be configured so that the formulation is held in a container not positioned directly vertical to and below the porous membrane, thus making it necessary to channel formulation horizontally to the porous membrane and making it possible to include a vibrating mechanism directly below a chamber covered by the porous membrane. Release of aerosolized drug is breath actuated based on simultaneous measurements of inspiratory flow and volume so as to provide for repeatable dosing of drug to the patient.

    摘要翻译： 提供了一次性包装，胶带和盒，其使得可以将含有药物活性药物的水性制剂（直径小于0.25微米的溶液或分散体）的液体可流动制剂保持并分散。 在一个实施方案中，将制剂包装在单独的剂量单位容器中，这些容器优选地互连。 包装被设计成集成到盒子中，该盒子可以装载到能够单独打开剂量单位容器并通过多孔膜将内容物雾化到分离盒中的口件中的分散装置中，用于递送给患者。 除了每个多孔膜之外并且旁边，包装可以包括一个或多个开口，通过该开口迫使空气以帮助避免雾化颗粒的积聚。 包装可以被配置成使得制剂保持在不直接垂直于多孔膜的下方的容器中，因此使得必须水平地配制到多孔膜上，并且使得可以在腔室的正下方包括振动机构 被多孔膜覆盖。 基于吸气流量和体积的同时测量，气雾化药物的释放是呼吸启动的，以便向患者提供药物的可重复剂量。

    Intrapulmonary delivery of hematopoietic drug
    6.
    发明授权
    Intrapulmonary delivery of hematopoietic drug 失效
    肺内输送造血药物

    公开(公告)号：US6012450A

    公开(公告)日：2000-01-11

    申请号：US673963

    申请日：1996-07-01

    申请人： Reid M. Rubsamen

    发明人： Reid M. Rubsamen

    IPC分类号： A61J7/04 ,  A61M15/00 ,  A61M16/00 ,  A61M16/10 ,  A61M11/00

    CPC分类号： A61M15/009 ,  A61M15/001 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0051 ,  A61M15/0066 ,  A61M15/008 ,  A61M16/108 ,  A61J7/0445 ,  A61M2016/0021 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2205/52 ,  A61M2205/8206

    摘要： A method of treating human patients is provided by the intrapulmonary delivery of a formulation containing a hematopoietic drug. The formulation is automatically released in an aerosolized form from a hand-held, self-contained, portable device comprised of a means for automatically releasing a measured amount of drug into the inspiratory flow path of a patient in response to information obtained from a means for measuring the inspiratory flow rate and determining the inspiratory volume of a patient. Reproducible dosing is obtained by providing for automatic release at the same inspiratory flow rate and inspiratory volume each time drug is released. The device includes a timer to enable a patient to take a drug at the same time each day. Further, overadministration of a hematopoietic drug formulation is avoided by providing a pre-programmed microprocessor designed to avoid overdosing.

    摘要翻译： 通过肺内递送含有造血药物的制剂来提供治疗人类患者的方法。 该制剂以手持式独立式便携式装置自动释放，包括用于响应于从患者的吸入流动路径获得的信息自动释放测量量的药物到患者的吸气流动路径中的装置， 测量吸气流速并确定患者的吸气体积。 通过在药物释放时以相同的吸气流速和吸气量提供自动释放，可以获得可再现的剂量。 该装置包括能够使患者每天同时服用药物的计时器。 此外，通过提供设计用于避免过量的预编程微处理器来避免造血药物制剂的过度给药。

    Disposable package for use in aerosolized delivery of drugs
    8.
    发明授权
    Disposable package for use in aerosolized delivery of drugs 失效
    一次性包装，用于雾化交付药物

    公开(公告)号：US5823178A

    公开(公告)日：1998-10-20

    申请号：US693593

    申请日：1996-08-02

    申请人： Lester John Lloyd ,  Peter M. Lloyd ,  Reid M. Rubsamen ,  Jeffrey Arthur Schuster

    发明人： Lester John Lloyd ,  Peter M. Lloyd ,  Reid M. Rubsamen ,  Jeffrey Arthur Schuster

    IPC分类号： B65D81/24 ,  A61J1/03 ,  A61J1/14 ,  A61J3/00 ,  A61J7/04 ,  A61K51/12 ,  A61M11/00 ,  A61M13/00 ,  A61M15/00 ,  A61M16/00 ,  B65D81/32 ,  B65D83/00

    CPC分类号： A61K51/1206 ,  A61M15/00 ,  A61M15/001 ,  A61M15/0031 ,  A61M15/0043 ,  A61M15/0051 ,  A61M15/0055 ,  A61M15/008 ,  B65D81/32 ,  A61J1/035 ,  A61J7/0418 ,  A61M11/002 ,  A61M15/0085 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2205/8206 ,  A61M2230/40

    摘要： A disposable package, tape, and cassette are provided which makes it possible to hold and disperse therefrom liquid, flowable formulations including aqueous formulations (solutions or dispersions with particles less than 0.25 microns in diameter) of a pharmaceutically active drug. In one embodiment formulation is packaged in individual dosage unit containers which containers are preferably interconnected. The package is designed to be integrated into a cassette which can be loaded into a dispersing device capable of individually opening dosage unit containers and aerosolizing the contents through a porous membrane, into a mouth piece on the cassette, for delivery to a patient. In addition to and alongside of each porous membrane, the package may include one or more openings through which air is forced in order to aid in avoiding the accumulation of aerosolized particles. The package may be configured so that the formulation is held in a container not positioned directly vertical to and below the porous membrane, thus making it necessary to channel formulation horizontally to the porous membrane and making it possible to include a vibrating mechanism directly below a chamber covered by the porous membrane. Release of aerosolized drug is breath actuated based on simultaneous measurements of inspiratory flow and volume so as to provide for repeatable dosing of drug to the patient.

    摘要翻译： 提供了一次性包装，胶带和盒，其使得可以将含有药物活性药物的水性制剂（直径小于0.25微米的溶液或分散体）的液体可流动制剂保持并分散。 在一个实施方案中，将制剂包装在单独的剂量单位容器中，这些容器优选地互连。 包装被设计成集成到盒子中，该盒子可以装载到能够单独打开剂量单位容器并通过多孔膜将内容物雾化到分离盒中的口件中的分散装置中，用于递送给患者。 除了每个多孔膜之外并且旁边，包装可以包括一个或多个开口，通过该开口迫使空气以帮助避免雾化颗粒的积聚。 包装可以被配置成使得制剂保持在不直接垂直于多孔膜的下方的容器中，因此使得必须水平地配制到多孔膜上，并且使得可以在腔室的正下方包括振动机构 被多孔膜覆盖。 基于吸气流量和体积的同时测量，气雾化药物的释放是呼吸启动的，以便向患者提供药物的可重复剂量。

    Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease
    9.
    发明授权
    Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease 失效
    将雾化药物递送至肺部治疗呼吸系统疾病的方法

    公开(公告)号：US5819726A

    公开(公告)日：1998-10-13

    申请号：US794481

    申请日：1997-02-04

    申请人： Reid M. Rubsamen ,  Lester John Lloyd

    发明人： Reid M. Rubsamen ,  Lester John Lloyd

    IPC分类号： A61J7/04 ,  A61M11/04 ,  A61M15/00 ,  A61M16/00 ,  A61M11/00

    CPC分类号： A61M15/0045 ,  A61M11/001 ,  A61M11/005 ,  A61M11/042 ,  A61M15/0051 ,  A61M15/009 ,  A61J7/0418 ,  A61M2016/0021 ,  A61M2202/062 ,  A61M2205/52 ,  A61M2205/6045

    摘要： A method of treating patients suffering from a respiratory disease using a programmable, hand-held, self-contained drug dispensing device is disclosed. A patient's inspiratory flow rate is measured and a determination is made of a typical and preferred rate and volume for the release of respiratory drug. To obtain repeatability in dosing the drug is repeatedly released at the same rate and volume. To maximize the amount of drug delivered based on the amount released the drug is released at a rate of from about 0.10 to about 2.0 liters/second and (2) a volume of about 0.15 to about 0.8 liters. Parameters such as rate, volume, and particle size of the aerosolized formulation are adjusted to obtain repeatable dosing of the maximum amount of drug to the desired area of the lung. Lung function is measured and use parameters are adjusted in order to improve lung function.

    摘要翻译： 公开了一种使用可编程手持式独立药物分配装置治疗患有呼吸系统疾病的患者的方法。 测量患者的吸气流速，并确定释放呼吸药物的典型和优选的速率和体积。 为了在给药中获得重复性，药物以相同的速率和体积重复释放。 为了最大限度地发挥药物的释放量，以药物释放量为约0.10至约2.0升/秒，（2）体积约0.15至约0.8升。 调整诸如雾化制剂的速率，体积和粒度的参数，以获得最大量的药物到肺的期望区域的可重复给药。 测量肺功能，调整使用参数以改善肺功能。