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    Insulin delivery enhanced by coached breathing
    3.
    发明授权
    Insulin delivery enhanced by coached breathing 失效
    通过辅导呼吸增强胰岛素输送

    公开(公告)号：US06408854B1

    公开(公告)日：2002-06-25

    申请号：US09553693

    申请日：2000-04-21

    申请人： Igor Gonda ,  Reid M. Rubsamen

    发明人： Igor Gonda ,  Reid M. Rubsamen

    IPC分类号： A61B1900

    CPC分类号： A61M15/00 ,  A61J7/0418 ,  A61J7/0427 ,  A61J7/0445 ,  A61K9/007 ,  A61K9/0073 ,  A61K38/28 ,  A61M11/001 ,  A61M15/0031 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0055 ,  A61M15/0066 ,  A61M15/008 ,  A61M15/0085 ,  A61M15/009 ,  A61M16/142 ,  A61M2016/0021 ,  A61M2016/0036 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2205/50 ,  A61M2205/8206

    摘要： The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of an inhale-exhale breathing maneuver. Particles of insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. The rate of absorption is enhanced by instructing the patient to inhale maximally and thereafter exhale maximally. This maneuver causes a spike in the rate at which insulin enters the circulatory system thereby increasing the rate at which glucose is removed from the circulatory system. The insulinmay be a dry powder but is preferably in a liquid formulation delivered to the patient from a hand-held, self-contained device which automatically releases an aerosolized burst of formulation. The device includes a sensor which is preferably electronic which measures inspiratory flow and volume which measurement can be used to control the point of drug release. The sensor can also assist the patient in the inhale-exhale maneuver.

    摘要翻译： 可以通过以下方法减少或消除对通过注射递送胰岛素的需要：将雾化的胰岛素制剂输送到患者的肺中，并且通过使用吸入呼气来增加胰岛素被吸收到血液中的速率 呼吸机动 输送到肺组织表面的胰岛素颗粒将被吸收到循环系统中。 通过指导患者最大限度吸入，然后最大程度地呼气，提高吸收率。 这种操作导致胰​​岛素进入循环系统的速率的峰值，从而增加从循环系统中除去葡萄糖的速率。 胰岛素可以是干粉，但是优选地是从手持式独立装置输送到患者的液体制剂，其自动释放雾化的制剂爆发。 该装置包括传感器，其优选是电子的，其测量吸气流量和体积，该测量可用于控制药物释放点。 传感器还可以帮助患者进行吸气呼气操作。

    Method for treating diabetes mellitus in a patient
    6.
    发明授权
    Method for treating diabetes mellitus in a patient 失效
    治疗患者糖尿病的方法

    公开(公告)号：US07278419B2

    公开(公告)日：2007-10-09

    申请号：US10768371

    申请日：2004-01-30

    申请人： Igor Gonda ,  Reid M. Rubsamen ,  Stephen J. Farr

    发明人： Igor Gonda ,  Reid M. Rubsamen ,  Stephen J. Farr

    IPC分类号： A61M11/00

    CPC分类号： A61K9/007 ,  A61J7/0418 ,  A61J7/0427 ,  A61J7/0445 ,  A61K9/0073 ,  A61K9/0075 ,  A61K38/28 ,  A61M11/001 ,  A61M15/00 ,  A61M15/0031 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0065 ,  A61M15/0066 ,  A61M15/008 ,  A61M15/0085 ,  A61M15/009 ,  A61M16/142 ,  A61M2016/0021 ,  A61M2016/0036 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2205/50 ,  A61M2205/8206

    摘要： The need for the delivery of insulin by injection can be reduced or eliminated by delivering aerosolized insulin. Repeatability of dosing is obtainable by using either regular insulin or monomeric insulin. When delivering insulin (not monomeric) by inhalation, the total inhaled volume should be about the same at each delivery to obtain repeatable results. The patient can be coached (by teaching) to inhale a given amount of air and can also be coached (by teaching) to inhale at a given flow rate. Further, the rate at which blood glucose is lowered is increased by the use of monomeric insulin. Particles of insulin and monomeric insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. A dry powder or a liquid insulin formulation is delivered to the patient from a mechanical or electronic hand-held, self-contained device.

    摘要翻译： 通过注射雾化胰岛素可以减少或消除通过注射输送胰岛素的需要。 给药的重复性可通过使用正常胰岛素或单体胰岛素获得。 当通过吸入输送胰岛素（非单体）时，每次输送时，总吸入体积应大致相同，以获得可重复的结果。 患者可以通过教学来吸引一定量的空气，也可以通过教导进行指导，以给定的流量进行吸气。 此外，通过使用单体胰岛素来增加血糖降低的速度。 输送到肺组织表面的胰岛素和单体胰岛素的颗粒将被吸收到循环系统中。 将干粉或液体胰岛素制剂从机械或电子手持式独立装置输送给患者。

    Method of maintaining a diabetic patient's blood glucose level in a desired range
    8.
    发明授权
    Method of maintaining a diabetic patient's blood glucose level in a desired range 失效
    将糖尿病患者的血糖水平维持在期望范围内的方法

    公开(公告)号：US5873358A

    公开(公告)日：1999-02-23

    申请号：US69891

    申请日：1998-04-29

    申请人： Igor Gonda ,  Reid M. Rubsamen

    发明人： Igor Gonda ,  Reid M. Rubsamen

    IPC分类号： A61J7/04 ,  A61K9/00 ,  A61K38/28 ,  A61M15/00 ,  A61M16/00 ,  A61M16/14 ,  A61M11/00

    CPC分类号： A61K9/007 ,  A61K38/28 ,  A61K9/0073 ,  A61M11/001 ,  A61M15/00 ,  A61M15/0031 ,  A61M15/0051 ,  A61M15/0066 ,  A61M15/008 ,  A61M16/142 ,  A61J7/0418 ,  A61J7/0427 ,  A61J7/0445 ,  A61M15/0085 ,  A61M15/009 ,  A61M2016/0021 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2205/8206

    摘要： The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of monomeric insulin and/or an inhale-exhale breathing maneuver. Particles of insulin and in particular monomeric insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. The rate of absorption is enhanced by the monomeric form of insulin and by instructing the patient to inhale maximally and thereafter exhale maximally. This maneuver causes a spike in the rate at which insulin enters the circulatory system thereby increasing the rate at which glucose is removed from the circulatory system. The insulin or insulin analog may be a dry powder but is preferably in a liquid formulation delivered to the patient from a hand-held, self-contained device which automatically releases an aerosolized burst of formulation. The device includes a sensor which is preferably electronic which measures inspiratory flow and volume which measurement can be used to control the point of drug release. The sensor can also assist the patient in the inhale-exhale maneuver.

    摘要翻译： 可以通过以下方法减少或消除对通过注射递送胰岛素的需要：将雾化的胰岛素制剂输送到患者的肺中，并且通过使用单体胰岛素和/或胰岛素来增加胰岛素被吸收到血液中的速率， 或吸气呼气机动。 胰岛素的颗粒，特别是递送到肺组织表面的单体胰岛素将被吸收到循环系统中。 通过胰岛素的单体形式和通过指导患者最大限度吸入，然后最大程度地呼出，吸收速率增强。 这种操作导致胰​​岛素进入循环系统的速率的峰值，从而增加从循环系统中除去葡萄糖的速率。 胰岛素或胰岛素类似物可以是干粉，但是优选地是从手持式独立装置输送到患者的液体制剂，其自动释放雾化的制剂爆发。 该装置包括传感器，其优选是电子的，其测量吸气流量和体积，该测量可用于控制药物释放点。 传感器还可以帮助患者进行吸气呼气操作。

    Method of treating diabetes mellitus in a patient
    9.
    发明授权
    Method of treating diabetes mellitus in a patient 失效
    治疗患者糖尿病的方法

    公开(公告)号：US07448375B2

    公开(公告)日：2008-11-11

    申请号：US11130986

    申请日：2005-05-17

    申请人： Igor Gonda ,  Reid M. Rubsamen ,  Stephen J. Farr

    发明人： Igor Gonda ,  Reid M. Rubsamen ,  Stephen J. Farr

    IPC分类号： A61M11/00

    CPC分类号： A61M15/0045 ,  A61M11/001 ,  A61M15/0043 ,  A61M15/0051 ,  A61M15/0066 ,  A61M15/008 ,  A61M15/0081 ,  A61M15/0083

    摘要： Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each time is consistent. A device for delivering insulin by inhalation is disclosed which device comprises a means for measuring inhaled volume and for halting inhalation at a pre-determined point. The device also comprises an adjustable means for applying various amounts of force to a container of formulation to expel different amounts of drug from the container based on the force applied.

    摘要翻译： 通过控制患者吸入的空气的总体积，将吸入胰岛素的剂量控制在狭窄的范围内。 通过以相同的总吸入体积的空气重复递送雾化胰岛素，每次输送给患者的胰岛素量是一致的。 公开了一种用于通过吸入递送胰岛素的装置，该装置包括用于测量吸入体积并在预定点停止吸入的装置。 该装置还包括可调节装置，用于根据施加的力将不同量的力施加到制剂容器以从容器中排出不同量的药物。

    Insulin delivery enhanced by coached breathing
    10.
    发明授权
    Insulin delivery enhanced by coached breathing 失效
    通过辅导呼吸增强胰岛素输送

    公开(公告)号：US06647987B2

    公开(公告)日：2003-11-18

    申请号：US10175597

    申请日：2002-06-18

    申请人： Igor Gonda ,  Reid M. Rubsamen

    发明人： Igor Gonda ,  Reid M. Rubsamen

    IPC分类号： A61B1900

    CPC分类号： A61M15/00 ,  A61J7/0418 ,  A61J7/0427 ,  A61J7/0445 ,  A61K9/007 ,  A61K9/0073 ,  A61K38/28 ,  A61M11/001 ,  A61M15/0031 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0055 ,  A61M15/0066 ,  A61M15/008 ,  A61M15/0085 ,  A61M15/009 ,  A61M16/142 ,  A61M2016/0021 ,  A61M2016/0036 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2205/50 ,  A61M2205/8206

    摘要： The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of an inhale-exhale breathing maneuver. Particles of insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. The rate of absorption is enhanced by instructing the patient to inhale maximally and thereafter exhale maximally. The insulin is delivered to the patient from a hand-held, self-contained device which automatically releases an aerosolized burst of formulation. The device includes a sensor which is preferably electronic which measures inspiratory flow and volume which measurement can be used to control the point of drug release. The sensor can also assist the patient in the inhale-exhale maneuver.

    摘要翻译： 可以通过以下方法减少或消除对通过注射递送胰岛素的需要：将雾化的胰岛素制剂输送到患者的肺中，并且通过使用吸入呼气来增加胰岛素被吸收到血液中的速率 呼吸机动 输送到肺组织表面的胰岛素颗粒将被吸收到循环系统中。 通过指导患者最大限度吸入，然后最大程度地呼气，提高吸收率。 胰岛素从手持式独立装置输送给患者，该装置自动释放雾化的制剂爆发。 该装置包括传感器，其优选是电子的，其测量吸气流量和体积，该测量可用于控制药物释放点。 传感器还可以帮助患者进行吸气呼气操作。