-
公开(公告)号：US20050234080A1
公开(公告)日：2005-10-20
申请号：US10515285
申请日：2003-05-19
Applicant: Paul Coleman , George Hartman , Lou Neilson
Inventor： Paul Coleman , George Hartman , Lou Neilson
IPC: A61K31/138 , A61K31/337 , A61K31/4465 , A61K31/513 , A61K31/5377 , A61K31/551 , A61K39/395 , A61K45/00 , A61P35/00 , C07D239/36 , C07D239/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/14
CPC classification number: C07D239/36 , C07D239/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/14 , C07D417/14
Abstract: The present invention relates to dihydropyrimidone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
Abstract translation: 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢嘧啶酮化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
-
公开(公告)号：US20060134767A1
公开(公告)日：2006-06-22
申请号：US10520492
申请日：2003-07-03
Applicant: Carolyn Buser-Doepner , Paul Coleman , Christopher Cox , Mark Fraley , Robert Garbaccio , George Hartman , David Heimbrook , Lawrence Kuo , Hans Huber , Vinod Sardana , Maricel Torrent , Youwei Yan
Inventor： Carolyn Buser-Doepner , Paul Coleman , Christopher Cox , Mark Fraley , Robert Garbaccio , George Hartman , David Heimbrook , Lawrence Kuo , Hans Huber , Vinod Sardana , Maricel Torrent , Youwei Yan
CPC classification number: C07K14/47 , C07K2299/00 , C12N9/14 , G01N33/6803 , G01N2500/04 , G16B15/00 , G16B20/00
Abstract: The present invention is directed to the identification, characterization and three-dimensional structure of a novel ligand binding site of KSP. Binding of ligands to the novel binding site result in a conformational change in the three-dimensional structure of the protein and a modulation of the activity of KSP. This conformational change in turn results in the formation of a novel binding pocket in the KSP protein, which comprises the novel binding site of the instant invention.
Abstract translation: 本发明涉及KSP新型配体结合位点的鉴定，表征和三维结构。 配体与新结合位点的结合导致蛋白质三维结构的构象变化和KSP活性的调节。 这种构象变化又导致在KSP蛋白质中形成新的结合口袋，其包含本发明的新结合位点。
-
公开(公告)号：US20050038074A1
公开(公告)日：2005-02-17
申请号：US10916096
申请日：2004-08-11
Applicant: Paul Coleman , Christopher Cox , Robert Garbaccio , George Hartman
Inventor： Paul Coleman , Christopher Cox , Robert Garbaccio , George Hartman
IPC: A61P35/00 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/454 , C07D43/02
CPC classification number: C07D413/14 , C04B35/632 , C07D401/12 , C07D401/14 , C07D417/14
Abstract: The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
Abstract translation: 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢吡咯化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
-
公开(公告)号：US20080027058A1
公开(公告)日：2008-01-31
申请号：US11630224
申请日：2005-06-27
Applicant: Paul Coleman , Christopher Cox , Mark Fraley , George Hartman , John Schreier
Inventor： Paul Coleman , Christopher Cox , Mark Fraley , George Hartman , John Schreier
IPC: A61K31/4155 , A61K31/454 , A61K31/496 , A61P35/00 , C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06
CPC classification number: C07D231/12 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/14 , C07D487/08 , C07D491/107 , C07D491/113
Abstract: The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
-
公开(公告)号：US20060100191A1
公开(公告)日：2006-05-11
申请号：US10531495
申请日：2003-10-14
Applicant: Michael Breslin , Paul Coleman , Christopher Cox , George Hartman , Brenda Mariano
Inventor： Michael Breslin , Paul Coleman , Christopher Cox , George Hartman , Brenda Mariano
IPC: A61K31/5377 , A61K31/454 , A61K31/4025 , A61K31/401 , C07D413/02 , C07D403/02
CPC classification number: C07D405/12 , C07D207/20 , C07D401/12 , C07D401/14 , C07D403/12
Abstract: The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
-
Patent Agency Ranking
公开(公告)号：US20050119484A1
公开(公告)日：2005-06-02
申请号：US10506702
申请日：2003-03-04
Applicant: Michael Breslin , Paul Coleman , Christopher Cox , J. christopher Culberson , George Hartman , Brenda Mariano , Maricel Torrent
Inventor： Michael Breslin , Paul Coleman , Christopher Cox , J. christopher Culberson , George Hartman , Brenda Mariano , Maricel Torrent
IPC: A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/00 , A61P35/00 , C07D231/06 , C07D231/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D417/04 , C07D43/02
CPC classification number: C07D401/04 , C04B35/632 , C07D231/06 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D417/04
Abstract: The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
Abstract translation: 本发明涉及可用于治疗细胞增殖性疾病，治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的二氢吡唑化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
-
公开(公告)号：US20060234984A1
公开(公告)日：2006-10-19
申请号：US10567676
申请日：2004-08-11
Applicant: Paul Coleman , Christopher Cox , Robert Garbaccio , George Hartman
Inventor： Paul Coleman , Christopher Cox , Robert Garbaccio , George Hartman
IPC: A61K31/454 , A61K31/675 , C07D403/02
CPC classification number: C04B35/632 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
Abstract: The present invention relates to dihydropyrrole compounds of Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
Abstract translation: 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的式（I）的二氢吡咯化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
-
公开(公告)号：US20080027118A1
公开(公告)日：2008-01-31
申请号：US11630303
申请日：2005-06-27
Applicant: Paul Coleman , Christopher Cox , George Hartman
Inventor： Paul Coleman , Christopher Cox , George Hartman
IPC: A61K31/415 , A61P35/00 , C07D231/02
CPC classification number: C07D231/06 , C07F9/65031
Abstract: The present invention relates to prodrugs of dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
Abstract translation: 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢吡唑化合物的前药。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
-
公开(公告)号：US20060105997A1
公开(公告)日：2006-05-18
申请号：US10517559
申请日：2003-06-12
Applicant: Kenneth Arrington , Paul Coleman , Christopher Cox , Mark Fraley , Robert Garbaccio , George Hartman , William Hoffman , Edward Tasber
Inventor： Kenneth Arrington , Paul Coleman , Christopher Cox , Mark Fraley , Robert Garbaccio , George Hartman , William Hoffman , Edward Tasber
IPC: A61K31/675 , A61K31/4025 , C07D43/02
CPC classification number: C07D401/12 , C07D207/14 , C07D207/20 , C07D207/48 , C07D265/30 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12
Abstract: The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
Abstract translation: 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢吡咯化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
-
公开(公告)号：US20050043357A1
公开(公告)日：2005-02-24
申请号：US10915743
申请日：2004-08-11
Applicant: Paul Coleman , Christopher Cox , Robert Garbaccio , George Hartman
Inventor： Paul Coleman , Christopher Cox , Robert Garbaccio , George Hartman
IPC: A61P35/00 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/454 , C07D43/02
CPC classification number: C04B35/632 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
Abstract: The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
-
-
-
-
-
-
-
-
-
Search Results
31
records
(took 0.042 seconds)
