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公开(公告)号：US20070254880A1
公开(公告)日：2007-11-01
申请号：US10593950
申请日：2005-03-23
申请人： Wesley Blackaby , Mark Duggan , David Hallett , George Hartman , Andrew Jennings , William Leister , Richard Lewis , Craig Lindsley , Elizabeth Naylor , Leslie Street , Yi Wang , David Wisnoski , Scott Wolkenberg , Zhijian Zhao
发明人： Wesley Blackaby , Mark Duggan , David Hallett , George Hartman , Andrew Jennings , William Leister , Richard Lewis , Craig Lindsley , Elizabeth Naylor , Leslie Street , Yi Wang , David Wisnoski , Scott Wolkenberg , Zhijian Zhao
IPC分类号： A61K31/445 , A61K31/5375 , C07D211/06 , C07D413/02
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D413/14
摘要： The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
摘要翻译： 本发明涉及抑制甘氨酸转运蛋白GlyT1的吡啶基，哒嗪基，嘧啶基和吡嗪基哌啶化合物，其可用于治疗与甘氨酸能或谷氨酸能神经传递功能障碍相关的神经和精神疾病以及其中涉及甘氨酸转运蛋白GlyT1的疾病 。
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公开(公告)号：US20070129356A1
公开(公告)日：2007-06-07
申请号：US10582826
申请日：2004-12-15
申请人： Kenneth Arrington , Mark Fraley , George Hartman
发明人： Kenneth Arrington , Mark Fraley , George Hartman
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/513 , C07D239/36
CPC分类号： C07D239/36
摘要： The present invention relates to 2-phenylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的2-苯基嘧啶酮化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20070088274A1
公开(公告)日：2007-04-19
申请号：US11517751
申请日：2006-09-08
IPC分类号： A61M5/178
CPC分类号： A61B17/3421 , A61B17/3423 , A61B17/3474 , A61B2017/00265 , A61B2090/064 , A61M37/00
摘要： A trocar assembly for use in surgery in a patient, comprising an elongated outer tubular member having a first or proximal end and a second or distal end. The proximal end has a housing enclosing a fluid pressure chamber therein. The distal end of the outer tubular member has a gaseous fluid discharge arrangement therethrough, through which a medical instrument is disposed for surgical manipulation of the patient.
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公开(公告)号：US20060234984A1
公开(公告)日：2006-10-19
申请号：US10567676
申请日：2004-08-11
IPC分类号： A61K31/454 , A61K31/675 , C07D403/02
CPC分类号： C04B35/632 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to dihydropyrrole compounds of Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的式（I）的二氢吡咯化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20050234080A1
公开(公告)日：2005-10-20
申请号：US10515285
申请日：2003-05-19
申请人： Paul Coleman , George Hartman , Lou Neilson
发明人： Paul Coleman , George Hartman , Lou Neilson
IPC分类号： A61K31/138 , A61K31/337 , A61K31/4465 , A61K31/513 , A61K31/5377 , A61K31/551 , A61K39/395 , A61K45/00 , A61P35/00 , C07D239/36 , C07D239/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/14
CPC分类号： C07D239/36 , C07D239/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to dihydropyrimidone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的二氢嘧啶酮化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20050032817A1
公开(公告)日：2005-02-10
申请号：US10497382
申请日：2002-12-02
申请人： Mark Fraley , George Hartman
发明人： Mark Fraley , George Hartman
IPC分类号： A61K31/138 , A61K31/4465 , A61K31/4535 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/5517 , A61K39/395 , A61K45/00 , A61P35/00 , C07D491/04 , C07D491/048 , C07D519/00 , C07D491/02
CPC分类号： C07D491/04
摘要： The present invention relates to furanopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的呋喃并嘧啶酮化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20050004512A1
公开(公告)日：2005-01-06
申请号：US10776923
申请日：2004-02-11
申请人： Michael Campbell , Donald Halgren , George Hartman , Ken Parker , Jack Stubbs , Ronald Thompson
发明人： Michael Campbell , Donald Halgren , George Hartman , Ken Parker , Jack Stubbs , Ronald Thompson
CPC分类号： A61B17/3498 , A61B17/3421 , A61B17/3423 , A61B17/3462 , A61B17/3474 , A61B2017/00265 , A61B2090/064
摘要： A cannula assembly for the maintenance of an operative pneumoperitoneum in a patient comprising an elongated cannula having a proximal end and a distal end. A removable valve is securely arranged in the proximal end of the cannula to provide a seal and minimize the escape of gas introduced into the patient's pneumoperitoneum when an operative instrument is passed therethrough.
摘要翻译： 一种用于维持患者手术气腹的插管组件，包括具有近端和远端的细长插管。 可移除的阀被牢固地布置在套管的近端中以提供密封并且当手术器械穿过其中时引入到患者气腹中的气体的逸出最小化。
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公开(公告)号：US20080027058A1
公开(公告)日：2008-01-31
申请号：US11630224
申请日：2005-06-27
申请人： Paul Coleman , Christopher Cox , Mark Fraley , George Hartman , John Schreier
发明人： Paul Coleman , Christopher Cox , Mark Fraley , George Hartman , John Schreier
IPC分类号： A61K31/4155 , A61K31/454 , A61K31/496 , A61P35/00 , C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06
CPC分类号： C07D231/12 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/14 , C07D487/08 , C07D491/107 , C07D491/113
摘要： The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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公开(公告)号：US20060100191A1
公开(公告)日：2006-05-11
申请号：US10531495
申请日：2003-10-14
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4025 , A61K31/401 , C07D413/02 , C07D403/02
CPC分类号： C07D405/12 , C07D207/20 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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公开(公告)号：US20050228003A1
公开(公告)日：2005-10-13
申请号：US10497553
申请日：2002-12-02
申请人： Mark Fraley , George Hartman , William Hoffman
发明人： Mark Fraley , George Hartman , William Hoffman
IPC分类号： A61K31/138 , A61K31/337 , A61K31/4465 , A61K31/4535 , A61K31/519 , A61K31/551 , A61K31/5513 , A61K39/395 , A61K45/00 , A61P35/00 , C07D495/04 , C07D498/02 , C07D519/00
CPC分类号： C07D495/04 , C07D519/00
摘要： The present invention relates to thienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的噻吩并嘧啶酮化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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