公开(公告)号：US08648193B2

公开(公告)日：2014-02-11

申请号：US12474326

申请日：2009-05-29

申请人： Olivier Ouari ,  Hakim Karoui ,  Francois Le Moigne ,  Paul Tordo ,  Robert G. Griffin ,  Yoh Matsuki ,  Thorsten Maly

发明人： Olivier Ouari ,  Hakim Karoui ,  Francois Le Moigne ,  Paul Tordo ,  Robert G. Griffin ,  Yoh Matsuki ,  Thorsten Maly

IPC分类号： C07D235/02 ,  C07D207/46 ,  C07D263/52 ,  C07D409/02 ,  C07D409/14

CPC分类号： G01N1/28 ,  C07D471/18 ,  C07D491/22 ,  G01R33/281 ,  G01R33/5601 ,  Y10T436/25

摘要： The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns dinitroxide-type biradical polarizing agents characterized by a rigid linkage between the nitroxide units that enables optimal orientation and distance to be maintained between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

摘要翻译： 本发明涉及有机化学领域，特别涉及在动态核极化（DNP）技术中用作极化剂的有机自由基，其涉及将电子自旋的极化转移到核磁共振的化合物的核上 （NMR）。 它涉及二硝基化型双基极化剂，其特征在于氮氧自由基之间的刚性连接，其能够在所述氮氧自由基单元的氨基之间保持最佳取向和距离。 这种特殊结构使得在低温和高场下，所研究的化合物的极化核的NMR / MAS信号的极化转移和最佳增强是最佳的。

公开(公告)号：US20100249386A1

公开(公告)日：2010-09-30

申请号：US12474326

申请日：2009-05-29

申请人： Olivier OUARI ,  Hakim KAROUI ,  Francois Le MOIGNE ,  Paul TORDO ,  Robert G. Griffin ,  Yoh Matsuki ,  Thorsten Maly

发明人： Olivier OUARI ,  Hakim KAROUI ,  Francois Le MOIGNE ,  Paul TORDO ,  Robert G. Griffin ,  Yoh Matsuki ,  Thorsten Maly

IPC分类号： C07D471/02 ,  C07D491/22 ,  C07K2/00 ,  C07H21/04 ,  C07H21/02 ,  C08B37/00 ,  A61K49/10

CPC分类号： G01N1/28 ,  C07D471/18 ,  C07D491/22 ,  G01R33/281 ,  G01R33/5601 ,  Y10T436/25

摘要： The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns dinitroxide-type biradical polarizing agents characterized by a rigid linkage between the nitroxide units that enables optimal orientation and distance to be maintained between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

摘要翻译： 本发明涉及有机化学领域，特别涉及在动态核极化（DNP）技术中用作极化剂的有机自由基，其涉及将电子自旋的极化转移到核磁共振的化合物的核上 （NMR）。 它涉及二硝基化型双基极化剂，其特征在于氮氧自由基之间的刚性连接，其能够在所述氮氧自由基单元的氨基之间保持最佳取向和距离。 这种特殊结构使得在低温和高场下，所研究的化合物的极化核的NMR / MAS信号的极化转移和最佳增强是最佳的。

公开(公告)号：US08786284B2

公开(公告)日：2014-07-22

申请号：US12930584

申请日：2011-01-11

申请人： Jagadishwar R. Sirigiri ,  Thorsten Maly

发明人： Jagadishwar R. Sirigiri ,  Thorsten Maly

IPC分类号： G01V3/00 ,  G01R33/28 ,  H01J25/02 ,  G01R33/3815

CPC分类号： G01R33/282 ,  G01R33/3607 ,  G01R33/3815 ,  G01R33/3873 ,  G01R33/3875 ,  G01R33/62 ,  H01J25/025

摘要： An integrated high-frequency generator system utilizing the magnetic field of the target application including a magnetic resonance magnet having an application zone and a high-frequency (microwave/terahertz) generator zone in the magnetic field of the magnetic resonance magnet; and a high-frequency (microwave/terahertz) generator disposed in the high-frequency (microwave/terahertz) generator zone and utilizing the magnet field of the magnetic resonance magnet to generate the high-frequency (microwave/terahertz) radiation. The magnetic resonance magnet may have an auxiliary magnetic field source for modifying the magnetic field profile in the high-frequency (microwave/terahertz) generator zone. The high-frequency (microwave/terahertz) generator may include an electron gun for generating an electron beam adapted to be focused by a magnetic field source having a spatially rising region, a homogenous region and a decaying region, an interaction structure for generating high-frequency (microwave/terahertz) radiation, an internal mode converter in the homogenous region for extracting the high-frequency (microwave/terahertz) radiation through a window, and a reduced collector disposed substantially in the homogenous region before the electron beam spreads in the decaying region.

摘要翻译： 一种利用目标应用的磁场的集成高频发生器系统，包括在磁共振磁体的磁场中具有应用区和高频（微波/太赫兹）发生器区的磁共振磁体; 以及设置在高频（微波/太赫兹）发生器区域中的高频（微波/太赫兹）发生器，并利用磁共振磁铁的磁场产生高频（微波/太赫兹）辐射。 磁共振磁体可以具有用于修改高频（微波/太赫兹）发生器区域中的磁场分布的辅助磁场源。 高频（微波/太赫兹）发生器可以包括用于产生适于被具有空间上升区域，均匀区域和衰减区域的磁场源聚焦的电子束的电子枪， 频率（微波/太赫兹）辐射，用于通过窗口提取高频（微波/太赫兹）辐射的均匀区域中的内部模式转换器，以及在电子束在衰减之前扩散的基本上位于均匀区域中的集电极 地区。

公开(公告)号：US20120176133A1

公开(公告)日：2012-07-12

申请号：US12930584

申请日：2011-01-11

申请人： Jagadishwar R. Sirigiri ,  Thorsten Maly

发明人： Jagadishwar R. Sirigiri ,  Thorsten Maly

IPC分类号： G01V3/00

CPC分类号： G01R33/282 ,  G01R33/3607 ,  G01R33/3815 ,  G01R33/3873 ,  G01R33/3875 ,  G01R33/62 ,  H01J25/025

摘要： An integrated high-frequency generator system utilizing the magnetic field of the target application including a magnetic resonance magnet having an application zone and a high-frequency (microwave/terahertz) generator zone in the magnetic field of the magnetic resonance magnet; and a high-frequency (microwave/terahertz) generator disposed in the high-frequency (microwave/terahertz) generator zone and utilizing the magnet field of the magnetic resonance magnet to generate the high-frequency (microwave/terahertz) radiation. The magnetic resonance magnet may have an auxiliary magnetic field source for modifying the magnetic field profile in the high-frequency (microwave/terahertz) generator zone. The high-frequency (microwave/terahertz) generator may include an electron gun for generating an electron beam adapted to be focused by a magnetic field source having a spatially rising region, a homogenous region and a decaying region, an interaction structure for generating high-frequency (microwave/terahertz) radiation, an internal mode converter in the homogenous region for extracting the high-frequency (microwave/terahertz) radiation through a window, and a reduced collector disposed substantially in the homogenous region before the electron beam spreads in the decaying region.

摘要翻译： 一种利用目标应用的磁场的集成高频发生器系统，包括在磁共振磁体的磁场中具有应用区和高频（微波/太赫兹）发生器区的磁共振磁体; 以及设置在高频（微波/太赫兹）发生器区域中的高频（微波/太赫兹）发生器，并利用磁共振磁铁的磁场产生高频（微波/太赫兹）辐射。 磁共振磁体可以具有用于修改高频（微波/太赫兹）发生器区域中的磁场分布的辅助磁场源。 高频（微波/太赫兹）发生器可以包括用于产生适于被具有空间上升区域，均匀区域和衰减区域的磁场源聚焦的电子束的电子枪， 频率（微波/太赫兹）辐射，用于通过窗口提取高频（微波/太赫兹）辐射的均匀区域中的内部模式转换器，以及在电子束在衰减之前扩散的基本上位于均匀区域中的集电极 地区。