公开(公告)号：US08648193B2

公开(公告)日：2014-02-11

申请号：US12474326

申请日：2009-05-29

申请人： Olivier Ouari ,  Hakim Karoui ,  Francois Le Moigne ,  Paul Tordo ,  Robert G. Griffin ,  Yoh Matsuki ,  Thorsten Maly

发明人： Olivier Ouari ,  Hakim Karoui ,  Francois Le Moigne ,  Paul Tordo ,  Robert G. Griffin ,  Yoh Matsuki ,  Thorsten Maly

IPC分类号： C07D235/02 ,  C07D207/46 ,  C07D263/52 ,  C07D409/02 ,  C07D409/14

CPC分类号： G01N1/28 ,  C07D471/18 ,  C07D491/22 ,  G01R33/281 ,  G01R33/5601 ,  Y10T436/25

摘要： The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns dinitroxide-type biradical polarizing agents characterized by a rigid linkage between the nitroxide units that enables optimal orientation and distance to be maintained between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

摘要翻译： 本发明涉及有机化学领域，特别涉及在动态核极化（DNP）技术中用作极化剂的有机自由基，其涉及将电子自旋的极化转移到核磁共振的化合物的核上 （NMR）。 它涉及二硝基化型双基极化剂，其特征在于氮氧自由基之间的刚性连接，其能够在所述氮氧自由基单元的氨基之间保持最佳取向和距离。 这种特殊结构使得在低温和高场下，所研究的化合物的极化核的NMR / MAS信号的极化转移和最佳增强是最佳的。

公开(公告)号：US20100249386A1

公开(公告)日：2010-09-30

申请号：US12474326

申请日：2009-05-29

申请人： Olivier OUARI ,  Hakim KAROUI ,  Francois Le MOIGNE ,  Paul TORDO ,  Robert G. Griffin ,  Yoh Matsuki ,  Thorsten Maly

发明人： Olivier OUARI ,  Hakim KAROUI ,  Francois Le MOIGNE ,  Paul TORDO ,  Robert G. Griffin ,  Yoh Matsuki ,  Thorsten Maly

IPC分类号： C07D471/02 ,  C07D491/22 ,  C07K2/00 ,  C07H21/04 ,  C07H21/02 ,  C08B37/00 ,  A61K49/10

CPC分类号： G01N1/28 ,  C07D471/18 ,  C07D491/22 ,  G01R33/281 ,  G01R33/5601 ,  Y10T436/25

摘要： The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns dinitroxide-type biradical polarizing agents characterized by a rigid linkage between the nitroxide units that enables optimal orientation and distance to be maintained between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

摘要翻译： 本发明涉及有机化学领域，特别涉及在动态核极化（DNP）技术中用作极化剂的有机自由基，其涉及将电子自旋的极化转移到核磁共振的化合物的核上 （NMR）。 它涉及二硝基化型双基极化剂，其特征在于氮氧自由基之间的刚性连接，其能够在所述氮氧自由基单元的氨基之间保持最佳取向和距离。 这种特殊结构使得在低温和高场下，所研究的化合物的极化核的NMR / MAS信号的极化转移和最佳增强是最佳的。