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公开(公告)号：US20170226465A1
公开(公告)日：2017-08-10
申请号：US15495435
申请日：2017-04-24
Applicant: OLYMPUS CORPORATION
Inventor： Hiroyuki KIMURA , Tatsuya MINAMI , Yasunori MAKARA
Abstract: A cell culture system of the present invention includes: a culture-medium storage part that holds a culture medium for culturing cells; a temporary holding part that is coupled to the culture-medium storage part and that is provided with a holding space for temporarily holding the culture medium supplied from the culture-medium storage part and a discharge port for discharging the culture medium; a culture-medium supply part that is coupled to the discharge port of the temporary holding part and that supplies the culture medium discharged from the temporary holding part, to a cell culture vessel; and a discharge part that discharges the culture medium from the cell culture vessel, wherein the culture-medium supply part is provided with a culture-medium intermittent supply mechanism that intermittently supplies the culture medium discharged from the temporary holding part, to the cell culture vessel in a predetermined cycle.
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公开(公告)号：US20200239827A1
公开(公告)日：2020-07-30
申请号：US16745530
申请日：2020-01-17
Applicant: OLYMPUS CORPORATION
Inventor： Hiroshi SASAKI , Tatsuya MINAMI , Yusuke MATSUMOTO
Abstract: The present invention provides an erythrocyte-culture monitoring device including a light source that radiates monochromatic light onto a culture solution culturing erythrocytes accommodated in a culture container, a first photodetector that detects a light intensity of the monochromatic light transmitted through the culture solution, and a controller that evaluates an amount of hemoglobin in the culture solution based on a temporal change in the light intensity detected by the photodetector.
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公开(公告)号：US20150344833A1
公开(公告)日：2015-12-03
申请号：US14721174
申请日：2015-05-26
Applicant: OLYMPUS CORPORATION
Inventor： Hiroyuki KIMURA , Tatsuya MINAMI , Yasunori MAKARA
CPC classification number: C12M29/26 , C12M23/14 , C12M23/48 , C12M25/02 , C12M29/14 , C12M41/12 , C12M41/40 , C12M41/48 , F04F3/00
Abstract: Supply and discharge of a solution, such as a medium, in a cell culture bag are easily controlled. Provided is a system including a sac-like cell culture bag having a supply port for supplying a solution, such as a medium, to the inside and having a discharge port for discharging the solution, such as a medium, from the inside, wherein gate opening and closing means for opening and closing inner holes of the supply port and the discharge port are attached to the supply port and the discharge port, and the gate opening and closing means are controlled to easily exchange the medium or the like in the cell culture bag.
Abstract translation: 容易地控制细胞培养袋中的溶液如培养基的供应和排出。 本发明提供一种系统，其包括囊状细胞培养袋，其具有用于向内部供给溶液的供给口（例如介质），并具有用于从内部排出介质的溶液的排出口，其中，门 用于打开和关闭供给口和排出口的内孔的打开和关闭装置附接到供给口和排出口，并且控制门开闭装置以容易地更换细胞培养物中的介质等 袋。
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公开(公告)号：US20200283721A1
公开(公告)日：2020-09-10
申请号：US16803345
申请日：2020-02-27
Applicant: OLYMPUS CORPORATION
Inventor： Tatsuya MINAMI , Yusuke MATSUMOTO
Abstract: A cell culture apparatus includes: a supply unit that supplies a culture medium to a culture tank accommodating the culture medium and cells; a discharge unit that discharges the culture medium and the cells from the culture tank; and one or more processors comprising hardware, the one or more processors being configured to determine whether or not cell density in the culture medium in the culture tank has exceeded a preliminarily set predetermined threshold, wherein in response to determining that the cell density has exceeded the predetermined threshold, the one or more processors are configured to cause the discharge unit to discharge a portion of the culture medium and the cells from the culture tank and cause the supply unit to supply a new culture medium to the culture tank to reduce the cell density to the predetermined threshold or less.
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公开(公告)号：US20170327782A1
公开(公告)日：2017-11-16
申请号：US15666551
申请日：2017-08-01
Applicant: OLYMPUS CORPORATION
Inventor： Hiroyuki KIMURA , Tatsuya MINAMI , Yasunori MAKARA
CPC classification number: C12M37/04 , C12M23/34 , C12M23/52 , C12M29/00 , C12M33/00 , C12M41/00 , C12M41/14
Abstract: Provided is a cell-culturing apparatus including a culturing unit in which a culturing vessel is placed and an incubator in which a plurality of culturing units are placed in an interior thereof, and that can maintain the interior thereof at an environment that is appropriate for cell culturing, wherein the incubator includes openings that are provided for each of the plurality of culturing units and through which the culturing units can separately be moved into and out of the incubator, and closing means that are provided at the openings and that seals off the internal environment of the incubator from outside when the culturing unit is taken out of the incubator.
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Patent Agency Ranking
公开(公告)号：US20170158996A1
公开(公告)日：2017-06-08
申请号：US15431153
申请日：2017-02-13
Applicant: OLYMPUS CORPORATION
Inventor： Hiroyuki KIMURA , Tatsuya MINAMI , Yasunori MAKARA
Abstract: A cell culture apparatus according to the present invention includes a cell culture bag and a culture tank. The cell culture bag is composed of a bag-shaped film material capable of accommodating cells and a culture medium therein. At least a part of the bag-shaped film material is formed of a porous membrane that selectively allows a substance contained in the culture medium to pass through but does not allow the cells to pass through. The culture tank retains the cell culture bag in an immersed state in a solution.
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公开(公告)号：US20170107475A1
公开(公告)日：2017-04-20
申请号：US15391804
申请日：2016-12-27
Applicant: OLYMPUS CORPORATION
Inventor： Hiroyuki KIMURA , Tatsuya MINAMI , Yasunori MAKARA
Abstract: A cell-culturing system includes: a solution-holding means holding a medium; and a solution-supplying means supplying the solution supplied thereto from the solution-holding means to a cell-culturing container. The solution-supplying means may supply a solution to the container via a solution dripping step. The container may be connected to the solution-supplying means at a position that is lower than the solution-supplying means in a direction in which gravity acts; the solution-supplying means may have a space in which the solution supplied thereto from the solution-holding means is made to drip; the system may be provided with a discharging port discharging the solution at a position in a container side surface at a desired height; and the solution may be discharged outside when the height of a top surface of the solution in the container reaches the port as a result of supplying the solution to the container from the solution-supplying means.
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公开(公告)号：US20170022469A1
公开(公告)日：2017-01-26
申请号：US15208663
申请日：2016-07-13
Applicant: OLYMPUS CORPORATION
Inventor： Hiroyuki KIMURA , Tatsuya MINAMI , Yasunori MAKARA
CPC classification number: C12M41/48 , C12M23/14 , C12M23/58 , C12M29/00 , C12M29/10 , C12M29/14 , C12M33/04 , C12M41/00 , C12M41/12 , C12M41/14 , C12M41/40 , C12M41/44
Abstract: A cell culturing apparatus according to the present invention includes a culture-medium retaining unit that retains a culture medium for culturing a cell, a culture bag provided with a feed port and a discharge port, a culture-medium feeding unit that connects the culture-medium retaining unit and the feed port and that feeds the culture medium from the culture-medium retaining unit to the culture bag, a negative-pressure supplying unit that supplies negative pressure to the discharge port, and a waste retaining unit that retains the culture medium from the discharge port.
Abstract translation: 本发明的细胞培养装置包括保留用于培养细胞的培养基的培养基保持单元，设置有进料口和排出口的培养袋，培养基培养装置， 介质保持单元和进料口，并且将培养基从培养基保持单元供给到培养袋，将负压供给到排出口的负压供给单元和保持培养基的废弃物保持单元 从排放口。
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公开(公告)号：US20180320120A1
公开(公告)日：2018-11-08
申请号：US16031312
申请日：2018-07-10
Applicant: OLYMPUS CORPORATION
Inventor： Hiroyuki KIMURA , Tatsuya MINAMI , Yasunori MAKARA
CPC classification number: C12M1/36 , B01L1/00 , B01L2300/02 , B01L2300/0861 , B01L2400/0457 , C12M3/00 , C12M23/02 , C12M23/42 , C12M29/00 , C12M41/32 , C12M41/44
Abstract: A cell culture container includes, in sequence from above in the gravity direction: a culture-medium holding container; a cell holding container that holds cells and a culture medium supplied from the culture-medium holding container through a supply port provided in the top surface thereof; a waste-liquid holding container that holds the culture medium discharged from the cell holding container; and a discharge mechanism for discharging the culture medium that has exceeded a predetermined level from the cell holding container to the waste-liquid holding container.
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公开(公告)号：US20180291328A1
公开(公告)日：2018-10-11
申请号：US16006399
申请日：2018-06-12
Applicant: OLYMPUS CORPORATION
Inventor： Hiroshi SASAKI , Tatsuya MINAMI , Yasunori MAKARA
Abstract: Provided is a cell-culturing apparatus including: an incubator that can maintain an interior thereof in an environment that is appropriate for growth of cells; a cell-culturing vessel that is accommodated inside the incubator; an optical-data acquisition unit that acquires optical data of a medium in the cell-culturing vessel; a medium changing unit that changes the medium in the cell-culturing vessel; and a controller, wherein a timing at which the medium is changed is determined on the basis of a change over time in the optical data acquired by the optical-data acquisition unit.
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