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公开(公告)号：US10669538B2
公开(公告)日：2020-06-02
申请号：US15293102
申请日：2016-10-13
Applicant: NUEVOLUTION A/S
Inventor： Henrik Pedersen , Alex Haahr Gouliaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Slok , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Thomas Thisted , Per-Ola Freskgard , Anette Holtmann
IPC: C12N15/10 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12P19/34 , C40B40/00
Abstract: The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The invention allows the generation of libraries which can be screened for e.g. therapeutic activity.
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公开(公告)号：US11702652B2
公开(公告)日：2023-07-18
申请号：US16744002
申请日：2020-01-15
Applicant: NUEVOLUTION A/S
Inventor： Thomas Franch , Mikkel Dybro Lundorf , Søren Nyboe Jakobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sørensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Sløk , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebæk Jensen , Lene Petersen , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Søren Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgard , Alex Haahr Gouliaev , Henrik Pedersen
CPC classification number: C12N15/1068 , C12N15/1089 , C40B40/08 , C40B50/04 , C40B50/06
Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
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公开(公告)号：US10077440B2
公开(公告)日：2018-09-18
申请号：US14794258
申请日：2015-07-08
Applicant: Nuevolution A/S
Inventor： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
IPC: C12N15/10 , C12Q1/6806 , C40B50/16 , C40B50/10
CPC classification number: C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
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Patent Agency Ranking
公开(公告)号：US09284600B2
公开(公告)日：2016-03-15
申请号：US14099106
申请日：2013-12-06
Applicant: Nuevolution A/S
Inventor： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schrøder Glad , Kim Birkebaek Jensen , Henrik Pedersen
CPC classification number: C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
Abstract translation: 公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个 反应物，并且提供标识起始位点处的反应物的各个标签是使用一种或多种酶。
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公开(公告)号：US10287576B2
公开(公告)日：2019-05-14
申请号：US15375929
申请日：2016-12-12
Applicant: NUEVOLUTION A/S
Inventor： Thomas Franch , Mikkel Dybro Lundorf , Søren Nyboe Jakobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sørensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Sløk , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebæk Jensen , Lene Petersen , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Søren Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgard , Alex Haahr Gouliaev , Henrik Pedersen
Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
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公开(公告)号：US09688980B2
公开(公告)日：2017-06-27
申请号：US14571941
申请日：2014-12-16
Applicant: NUEVOLUTION A/S
Inventor： Henrik Pedersen , Alex Haahr Gouliaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Slok , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Thomas Thisted , Per-Ola Freskgard , Anette Holtmann
IPC: C40B40/06 , C40B40/10 , C12N15/10 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12P19/34 , C40B40/00
CPC classification number: C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
Abstract: The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
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公开(公告)号：US09487775B2
公开(公告)日：2016-11-08
申请号：US14861735
申请日：2015-09-22
Applicant: Nuevolution A/S
Inventor： Thomas Franch , Alex Haahr Gouliaev , Per-Ola Freskgard , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Birkebaek Jensen , Kim Birkebaek Jensen , Henrik Pedersen
CPC classification number: C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
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公开(公告)号：US11001835B2
公开(公告)日：2021-05-11
申请号：US16056891
申请日：2018-08-07
Applicant: Nuevolution A/S
Inventor： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
IPC: C12N15/10 , C12Q1/6806 , C40B50/16 , C40B50/10
Abstract: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
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