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公开(公告)号：US20210269388A1
公开(公告)日：2021-09-02
申请号：US17317179
申请日：2021-05-11
摘要： A highly unsaturated fatty acid or a highly unsaturated fatty acid ethyl ester that has been produced using as a feedstock oil a fat or oil that contains highly unsaturated fatty acids as constituent fatty acids and which has been reduced in the contents of environmental pollutants, wherein among the dioxins contained, polychlorinated dibenzoparadioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are contained in amounts of less than 0.05 pg-TEQ/g and coplanar PCBs (Co-PCBs) in amounts of less than 0.03 pg-TEQ/g. Also disclosed is a method for producing the highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester by the steps of removing free fatty acids and environmental pollutants by thin-film distillation from a feedstock oil, ethyl esterifying the resulting fat or oil, and refining the same by rectification and column chromatography.
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公开(公告)号：US20190337883A1
公开(公告)日：2019-11-07
申请号：US16514191
申请日：2019-07-17
IPC分类号： C07C69/587 , C07C57/03 , C07C67/54 , C07C67/56 , C07C67/03 , C11B3/12 , C07C51/44 , B01D3/14 , C07C51/47 , B01D15/32
摘要： A highly unsaturated fatty acid or a highly unsaturated fatty acid ethyl ester that has been produced using as a feedstock oil a fat or oil that contains highly unsaturated fatty acids as constituent fatty acids and which has been reduced in the contents of environmental pollutants, wherein among the dioxins contained, polychlorinated dibenzoparadioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are contained in amounts of less than 0.05 pg-TEQ/g and coplanar PCBs (Co-PCBs) in amounts of less than 0.03 pg-TEQ/g. Also disclosed is a method for producing the highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester by the steps of removing free fatty acids and environmental pollutants by thin-film distillation from a feedstock oil, ethyl esterifying the resulting fat or oil, and refining the same by rectification and column chromatography.
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3.发明申请公开(公告)号：US20180147176A1
公开(公告)日：2018-05-31
申请号：US15878827
申请日：2018-01-24
发明人： Nobushige DOISAKI , Shingo ARATO , Takuro FUKAE
IPC分类号： A61K31/232 , C07C67/54 , C07C67/03 , C07C69/587 , C07C67/56 , C11C3/10 , C11B3/12
CPC分类号： A61K31/232 , C07C67/03 , C07C67/54 , C07C67/56 , C07C69/587 , C11B3/12 , C11C3/10
摘要： Provided are: a composition containing 96-99 area % of eicosapentaenoic acid alkyl ester, the composition having an arachidonic acid alkyl ester content of 0.7 area % or less, and an eicosapentaenoic-acid-alkyl-ester mono-trans isomer content of 2.5 area % or less; and a method for producing a composition containing a high concentration of eicosapentaenoic acid alkyl ester, the method including performing precision distillation on a composition containing eicosapentaenoic acid alkyl ester, obtained by alkyl esterification of a raw material oil containing eicosapentaenoic acid, under a vacuum of 0.2 Ton or lower and a temperature of 190° C. or lower in the entire column, and performing a concentration treatment on the precision-distilled composition using chromatography.
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公开(公告)号：US20170252315A1
公开(公告)日：2017-09-07
申请号：US15511757
申请日：2015-09-17
发明人： Nobushige DOISAKI , Shingo ARATO , Takuro FUKAE
IPC分类号： A61K31/232
CPC分类号： A61K31/232 , C07C67/03 , C07C67/54 , C07C67/56 , C07C69/587 , C11B3/12 , C11C3/10
摘要： Provided are: an eicosapentaenoic acid alkyl ester-containing composition which comprises 96-99 area % of an eicosapentaenoic acid alkyl ester, wherein the content of an arachidonic acid alkyl ester is 0.7 area % or less, and the content of mono-trans forms of the eicosapentaenoic acid alkyl ester is 2.5 area % or less; a method for producing a high-concentration eicosapentaenoic acid alkyl ester-containing composition, which comprises performing rectification on an eicosapentaenoic acid alkyl ester-containing composition with the degree of vacuum being 0.2 Torr or less and at a whole-column temperature 190° C. or less, and performing a concentration treatment on the rectified composition using chromatography, the eicosapentaenoic acid alkyl ester-containing composition being obtained by alkyl esterifying a feed oil containing eicosapentaenoic acid.
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公开(公告)号：US20220248671A1
公开(公告)日：2022-08-11
申请号：US17720595
申请日：2022-04-14
发明人： Hideaki YAMAGUCHI , Yuhei KOSUGE , Rie IKEDA , Nobushige DOISAKI , Seizo SATO
IPC分类号： A01N37/06 , A61K31/202 , C11B1/02 , C11B3/12 , C11C1/00 , A61K8/36 , A61Q19/00 , A23L33/115 , C12N1/28 , C12P7/6427 , C12P7/6436 , C12P7/6463 , A23D9/013 , A23D9/02 , C11B3/10 , C11C3/10 , A23K20/158 , A61K8/9706 , A61K8/9728 , A61K8/99 , A61K36/06
摘要： A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.
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公开(公告)号：US20210139813A1
公开(公告)日：2021-05-13
申请号：US17154646
申请日：2021-01-21
摘要： PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition.
MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.-
7.发明申请MICROBIAL OIL, PRODUCTION METHOD FOR MICROBIAL OIL, CONCENTRATED MICROBIAL OIL, AND PRODUCTION METHOD FOR CONCENTRATED MICROBIAL OIL 审中-公开微生物油，微生物油的生产方法，浓缩微生物油和浓缩微生物油的生产方法公开(公告)号：US20160317592A1
公开(公告)日：2016-11-03
申请号：US15101436
申请日：2014-12-04
发明人： Hideaki YAMAGUCHI , Yuhei KOSUGE , Rie IKEDA , Nobushige DOISAKI , Seizo SATO
IPC分类号： A61K36/06 , A61K31/202 , A23K20/158 , A23D9/013 , A23D9/02
CPC分类号： A01N37/06 , A23D9/013 , A23D9/02 , A23K20/158 , A23L33/115 , A61K8/361 , A61K8/99 , A61K31/202 , A61K36/06 , A61Q19/00 , C11B1/025 , C11B3/10 , C11B3/12 , C11C1/005 , C11C3/10 , C12N1/28 , C12P7/6427 , C12P7/6436 , C12P7/6463
摘要： A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.
摘要翻译： 一种微生物油，其包含：特定量的至少一种在脂肪酸烷基酯形式和/或游离脂肪酸形式中具有至少20个碳原子的多不饱和脂肪酸; 特定量的脂肪酸烷基酯形式的碳原子数为16〜22的热产生脂肪酸和/或游离脂肪酸形式。 一种制备方法，其包括：提供含有至少一种具有至少20个碳原子的多不饱和脂肪酸的起始油，其为烷基酯形式和/或由微生物生物质获得的游离脂肪酸形式; 在特定条件下对原油进行整改; 得到上述微生物油。 使用上述制造方法得到的浓缩微生物油及其制造方法。 用于治疗或预防包含微生物油或浓缩微生物油的炎性疾病的药剂。
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公开(公告)号：US20230055343A1
公开(公告)日：2023-02-23
申请号：US17962984
申请日：2022-10-10
摘要： PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition.
MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.-
公开(公告)号：US20220348841A1
公开(公告)日：2022-11-03
申请号：US17860234
申请日：2022-07-08
IPC分类号： C11C3/00 , A23D9/007 , C07C69/58 , C07C57/12 , A61K31/201 , A61K31/202 , A23L33/12
摘要： The present disclosure is: a free polyunsaturated fatty acid-containing composition, which comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, the content being at least 80.0% of the fatty acids in the composition, and satisfies at least one selected from a group consisting of conditions (1) and (2): (1) the content of conjugated unsaturated fatty acid is 1.0% or less of the fatty acids in the composition, and (2) the Gardner color is less than 3+; and a manufacturing method for the free polyunsaturated fatty acid-containing composition comprising the preparation of a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms, and hydrolysis of a reaction solution containing the prepared raw material composition, a lower alcohol, water and an alkali catalyst at a temperature of 10° C. or lower.
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10.发明申请公开(公告)号：US20210324432A1
公开(公告)日：2021-10-21
申请号：US17273144
申请日：2019-09-04
摘要： The present invention provides a method of producing a composition containing docosahexaenoic acid as a constituent fatty acid of glycerides, comprising hydrolyzing a feedstock oil containing glycerides comprising docosahexaenoic acid as a constituent fatty acid by action of a Candida cylindracea derived lipase and a partial glyceride lipase, thereby increasing the proportion of docosahexaenoic acid in glyceride fractions, wherein the lipase hydrolysis reaction is performed at a temperature no higher than 30° C. for a period no longer than 15 hours.
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