公开(公告)号：US20180042230A1

公开(公告)日：2018-02-15

申请号：US15792963

申请日：2017-10-25

申请人： NIPPON SUISAN KAISHA, LTD.

发明人： Seizo SATO ,  Takuro FUKAE ,  Naomi OHTSUKA ,  Hideaki YAMAGUCHI ,  Rie IKEDA

IPC分类号： A01N37/06 ,  C12N1/28 ,  C11C3/10 ,  C11C1/00 ,  C11B3/12 ,  C11B3/10 ,  C11B1/02 ,  A61Q19/00 ,  A61K36/06 ,  A61K31/202 ,  A61K8/99 ,  A61K8/36 ,  A23D9/02 ,  A23D9/013 ,  C12P7/64

摘要： A microbial oil comprising dihomo-γ-linolenic acid as a constituent fatty acid of an oil, the microbial oil has a content, in terms of a weight ratio of arachidonic acid relative to dihomo-γ-linolenic acid (arachidonic acid/dihomo-γ-linolenic acid) of less than 1/13. Preferably, the microbial oil has a triglyceride content of greater than or equal to 70% by weight, and a saturated fatty acid content of less than or equal to 40% by weight. Moreover, a lower alcohol ester of dihomo-γ-linolenic acid or a free fatty acid of dihomo-γ-linolenic acid obtained from the microbial oil is provided.

公开(公告)号：US20220248671A1

公开(公告)日：2022-08-11

申请号：US17720595

申请日：2022-04-14

申请人： NIPPON SUISAN KAISHA, LTD.

发明人： Hideaki YAMAGUCHI ,  Yuhei KOSUGE ,  Rie IKEDA ,  Nobushige DOISAKI ,  Seizo SATO

IPC分类号： A01N37/06 ,  A61K31/202 ,  C11B1/02 ,  C11B3/12 ,  C11C1/00 ,  A61K8/36 ,  A61Q19/00 ,  A23L33/115 ,  C12N1/28 ,  C12P7/6427 ,  C12P7/6436 ,  C12P7/6463 ,  A23D9/013 ,  A23D9/02 ,  C11B3/10 ,  C11C3/10 ,  A23K20/158 ,  A61K8/9706 ,  A61K8/9728 ,  A61K8/99 ,  A61K36/06

摘要： A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.

公开(公告)号：US20170000116A1

公开(公告)日：2017-01-05

申请号：US15101581

申请日：2014-12-04

申请人： NIPPON SUISAN KAISHA, LTD.

发明人： Seizo SATO ,  Takuro FUKAE ,  Naomi OHTSUKA ,  Hideaki YAMAGUCHI ,  Rie IKEDA

IPC分类号： A01N37/06 ,  C12N1/28 ,  C12P7/64 ,  C11B3/10

CPC分类号： A01N37/06 ,  A23D9/013 ,  A23D9/02 ,  A23K20/158 ,  A23L33/115 ,  A61K8/361 ,  A61K8/99 ,  A61K31/202 ,  A61K36/06 ,  A61Q19/00 ,  C11B1/025 ,  C11B3/10 ,  C11B3/12 ,  C11C1/005 ,  C11C3/10 ,  C12N1/28 ,  C12P7/6427 ,  C12P7/6436 ,  C12P7/6463

摘要： A microbial oil comprising dihomo-γ-linolenic acid as a constituent fatty acid of an oil, the microbial oil has a content, in terms of a weight ratio of arachidonic acid relative to dihomo-γ-linolenic acid (arachidonic acid/dihomo-γ-linolenic acid) of less than 1/13. Preferably, the microbial oil has a triglyceride content of greater than or equal to 70% by weight, and a saturated fatty acid content of less than or equal to 40% by weight. Moreover, a lower alcohol ester of dihomo-γ-linolenic acid or a free fatty acid of dihomo-γ-linolenic acid obtained from the microbial oil is provided.

摘要翻译： 作为油的构成脂肪酸的二胡-γ-亚麻酸的微生物油，以花生四烯酸相对于二高-γ-亚麻酸的重量比（花生四烯酸/二高-γ - 亚麻酸）小于1/13。 优选地，微生物油的甘油三酯含量大于或等于70重量％，饱和脂肪酸含量小于或等于40重量％。 此外，提供了由微生物油获得的二高-γ-亚麻酸的低级醇酯或二 - γ-亚麻酸的游离脂肪酸。

公开(公告)号：US20160317592A1

公开(公告)日：2016-11-03

申请号：US15101436

申请日：2014-12-04

申请人： NIPPON SUISAN KAISHA, LTD.

发明人： Hideaki YAMAGUCHI ,  Yuhei KOSUGE ,  Rie IKEDA ,  Nobushige DOISAKI ,  Seizo SATO

IPC分类号： A61K36/06 ,  A61K31/202 ,  A23K20/158 ,  A23D9/013 ,  A23D9/02

CPC分类号： A01N37/06 ,  A23D9/013 ,  A23D9/02 ,  A23K20/158 ,  A23L33/115 ,  A61K8/361 ,  A61K8/99 ,  A61K31/202 ,  A61K36/06 ,  A61Q19/00 ,  C11B1/025 ,  C11B3/10 ,  C11B3/12 ,  C11C1/005 ,  C11C3/10 ,  C12N1/28 ,  C12P7/6427 ,  C12P7/6436 ,  C12P7/6463

摘要： A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.

摘要翻译： 一种微生物油，其包含：特定量的至少一种在脂肪酸烷基酯形式和/或游离脂肪酸形式中具有至少20个碳原子的多不饱和脂肪酸; 特定量的脂肪酸烷基酯形式的碳原子数为16〜22的热产生脂肪酸和/或游离脂肪酸形式。 一种制备方法，其包括：提供含有至少一种具有至少20个碳原子的多不饱和脂肪酸的起始油，其为烷基酯形式和/或由微生物生物质获得的游离脂肪酸形式; 在特定条件下对原油进行整改; 得到上述微生物油。 使用上述制造方法得到的浓缩微生物油及其制造方法。 用于治疗或预防包含微生物油或浓缩微生物油的炎性疾病的药剂。