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公开(公告)号：US11898190B2
公开(公告)日：2024-02-13
申请号：US17401894
申请日：2021-08-13
Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION , KONAN GAKUEN , NIPPON SUISAN KAISHA, LTD.
Inventor： Yuji Okita , Makoto Ito , Rie Hamaguchi , Hatsumi Goda , Seiya Mochinaga , Daisuke Honda
IPC: C12P7/6432 , C12N15/09 , C12P7/64 , C12P1/00 , C12N15/79 , C12P7/6427 , C12P7/6472 , C12P19/34 , C12N1/00 , C12N1/12 , C12R1/00 , C12R1/89 , C10G3/00 , C12N15/52
CPC classification number: C12P7/6432 , C12N15/09 , C12N15/79 , C12P1/00 , C12P7/64 , C12P7/6427 , C12P7/6472 , C12P19/34 , C10G3/00 , C12N1/00 , C12N1/125 , C12N15/52 , C12R2001/00 , C12R2001/89
Abstract: A method for producing a microbial oil includes steps of: genetically modifying a labyrinthulid by disrupting and/or silencing a gene, or by transforming another gene in addition to the disruption and/or gene silencing of the gene, and culturing the labyrinthulid, such that a fatty acid composition accumulated in the labyrinthulid comprises an increased EPA content; and collecting the microbial oil having the increased EPA content from the labyrinthulid. The labyrinthulid before the modification is selected from (A) a labyrinthulid belonging to the genus Parietichytrium or genus Schizochytrium and having very weak or no activity of producing PUFAs via a PUFA-PKS pathway; and (B) a labyrinthulid belonging to the genus Thraustochytrium in which a host PUFA-PKS gene is disrupted or silenced to a very weak level. The increased EPA content is preferably not less than 11.5% of a total fatty acid composition.
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公开(公告)号：US11679091B2
公开(公告)日：2023-06-20
申请号：US16968321
申请日：2019-02-08
Applicant: NIPPON SUISAN KAISHA, LTD.
Inventor： Kenichi Yanagimoto , Li Han , Bungo Shirouchi
IPC: A61K31/202 , A23L33/12 , A23L33/00 , A61P7/10 , A61K31/232
CPC classification number: A61K31/202 , A23L33/12 , A23L33/40 , A61K31/232 , A61P7/10 , A23V2002/00
Abstract: The present invention provides a composition for improving lymphatic circulation, which contains a component selected from at least one highly unsaturated fatty acid, salt thereof, and ester thereof as an active ingredient. The present invention also provides a composition for improving lymphatic circulation, which contains as active ingredients a triglyceride comprising the at least one highly unsaturated fatty acid as a constituent fatty acid and a triglyceride comprising the at least one middle chain fatty acid as a constituent fatty acid. The present invention also provides a composition for improving lymphatic circulation, which contains as an active ingredient a triglyceride comprising the at least one highly unsaturated fatty acid and the at least one middle chain fatty acid as constituent fatty acids.
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公开(公告)号：US11617732B2
公开(公告)日：2023-04-04
申请号：US16615254
申请日：2018-05-23
Applicant: NIPPON SUISAN KAISHA, LTD.
Inventor： Rie Tsutsumi , Jiro Takeo , Hiroko Miyahara , Hiroshi Sakaue
IPC: A61K31/201 , A61P9/14 , A61K31/231 , A61K35/60
Abstract: The present invention provides a composition for improving vascular endothelial function, comprising: an ingredient selected from a monounsaturated fatty acid having 20 carbon atoms or more, a salt thereof, and an ester thereof as an active ingredient, in which the ratio of the monounsaturated fatty acid having 20 carbon atoms or more to the total fatty acids in the composition is 10 wt % or greater. The present invention also provides a composition for improving sleep, comprising an ingredient selected from a monounsaturated fatty acid having 20 carbon atoms or more, a salt thereof, and an ester thereof as an active ingredient.
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公开(公告)号：US20210346330A1
公开(公告)日：2021-11-11
申请号：US17380900
申请日：2021-07-20
Applicant: NIPPON SUISAN KAISHA, LTD.
Inventor： Jiro TAKEO , Hiroyuki KAWAHARA
IPC: A61K31/202 , A61K9/00 , A61K47/06 , A61K31/683 , A61P17/00 , A61P17/04 , A61K31/232 , A61K31/685 , A61K31/7032
Abstract: [Problem] To provide a composition for external skin use that has anti-inflammatory and antiallergic activity, and is very safe. [Solution] A composition for external skin use for inflammatory diseases contains dihomo-gamma-linolenic acid (DGLA) as the active ingredient thereof. It is preferable for the DGLA to be present as a glyceride, a phospholipid, or an alkyl ester. The amount of DGLA contained in the composition for external use is 0.1-50 wt %.
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公开(公告)号：US20210315187A1
公开(公告)日：2021-10-14
申请号：US17352680
申请日：2021-06-21
Applicant: NIPPON SUISAN KAISHA, LTD.
Inventor： Hiroshi MINAMI , Kosuke MATSUOKA
IPC: A01K61/59 , A61K35/612 , A23K20/105 , A23K50/80 , A23L17/40 , A23K20/179 , A61P43/00
Abstract: A method of rearing an aquaculture shrimp includes keeping shrimps in a land-farming nursery, and feeding to the shrimps kept in the land-farming nursery a feed including astaxanthin in an amount of 50 ppm or greater.
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Patent Agency Ranking
公开(公告)号：US20210269388A1
公开(公告)日：2021-09-02
申请号：US17317179
申请日：2021-05-11
Applicant: NIPPON SUISAN KAISHA, LTD.
Inventor： Nobushige DOISAKI , Kazuhiko HATA , Shinji TOKIWA , Kazunori MATSUSHIMA
Abstract: A highly unsaturated fatty acid or a highly unsaturated fatty acid ethyl ester that has been produced using as a feedstock oil a fat or oil that contains highly unsaturated fatty acids as constituent fatty acids and which has been reduced in the contents of environmental pollutants, wherein among the dioxins contained, polychlorinated dibenzoparadioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are contained in amounts of less than 0.05 pg-TEQ/g and coplanar PCBs (Co-PCBs) in amounts of less than 0.03 pg-TEQ/g. Also disclosed is a method for producing the highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester by the steps of removing free fatty acids and environmental pollutants by thin-film distillation from a feedstock oil, ethyl esterifying the resulting fat or oil, and refining the same by rectification and column chromatography.
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公开(公告)号：US11034643B2
公开(公告)日：2021-06-15
申请号：US16514191
申请日：2019-07-17
Applicant: NIPPON SUISAN KAISHA, LTD.
Inventor： Nobushige Doisaki , Kazuhiko Hata , Shinji Tokiwa , Kazunori Matsushima
IPC: C07C69/587 , C07C67/03 , C07C67/54 , C07C67/56 , C07C51/47 , C07C57/03 , C11C3/00 , A23D9/02 , C11B3/12 , A23L33/115 , A61K31/20 , A61K31/202 , A61K31/232 , B01D3/14 , B01D15/32 , C07C51/44 , C11B3/16
Abstract: A highly unsaturated fatty acid or a highly unsaturated fatty acid ethyl ester that has been produced using as a feedstock oil a fat or oil that contains highly unsaturated fatty acids as constituent fatty acids and which has been reduced in the contents of environmental pollutants, wherein among the dioxins contained, polychlorinated dibenzoparadioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are contained in amounts of less than 0.05 pg-TEQ/g and coplanar PCBs (Co-PCBs) in amounts of less than 0.03 pg-TEQ/g. Also disclosed is a method for producing the highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester by the steps of removing free fatty acids and environmental pollutants by thin-film distillation from a feedstock oil, ethyl esterifying the resulting fat or oil, and refining the same by rectification and column chromatography.
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公开(公告)号：US10952414B2
公开(公告)日：2021-03-23
申请号：US16542572
申请日：2019-08-16
Applicant: Nippon Suisan Kaisha, Ltd.
Inventor： Hiroshi Minami , Mitsuho Maeda , Eisuke Yasue , Kosuke Matsuoka
Abstract: An aquaculture system including an aquaculture tank for holding aquaculture water for culturing an aquatic organism, a thermal insulation house that covers the aquaculture tank, an insulation positioned on at least part of a region surrounding the aquaculture tank, and a temperature adjuster that adjusts a temperature inside the thermal insulation house and/or a temperature of the aquaculture water in the aquaculture tank.
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公开(公告)号：US10815505B2
公开(公告)日：2020-10-27
申请号：US15886599
申请日：2018-02-01
Applicant: KYUSHU UNIVERSITY, NAT'L UNIVERSITY CORPORATION , UNIVERSITY OF MIYAZAKI , KONAN GAKUEN , NIPPON SUISAN KAISHA, LTD.
Inventor： Keishi Sakaguchi , Takanori Matsuda , Takumi Kobayashi , Makoto Ito , Naoki Nagano , Masahiro Hayashi , Daisuke Honda , Yosuke Taoka , Yuji Okita , Hitoshi Izumida , Shinichi Sugimoto
Abstract: A microbial oil is extracted from stramenopile transformed with a gene associated with synthesis of fatty acids, the gene encoding a fatty acid desaturase. The stramenopile belongs to the class Labyrinthulomycete. The microbial oil satisfies one or more of the following requirements: (a) an amount of arachidonic acid is 7% or less based on a total amount of the fatty acid composition; (b) an amount of DPA is 9% or less based on the total amount of the fatty acid composition; (c) an amount of ETA is 0.04% or more based on the total amount of the fatty acid composition; (d) an amount of EPA is 7% or more based on the total amount of the fatty acid composition; and (e) an amount of DHA is 45% or more based on the total amount of the fatty acid composition.
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公开(公告)号：US10696924B1
公开(公告)日：2020-06-30
申请号：US16404662
申请日：2019-05-06
Applicant: NIPPON SUISAN KAISHA, LTD.
Inventor： Nobushige Doisaki , Kiyomi Furihata , Hideaki Yamaguchi
Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition.MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.
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