公开(公告)号：US20220248671A1

公开(公告)日：2022-08-11

申请号：US17720595

申请日：2022-04-14

Applicant: NIPPON SUISAN KAISHA, LTD.

Inventor： Hideaki YAMAGUCHI ,  Yuhei KOSUGE ,  Rie IKEDA ,  Nobushige DOISAKI ,  Seizo SATO

IPC: A01N37/06 ,  A61K31/202 ,  C11B1/02 ,  C11B3/12 ,  C11C1/00 ,  A61K8/36 ,  A61Q19/00 ,  A23L33/115 ,  C12N1/28 ,  C12P7/6427 ,  C12P7/6436 ,  C12P7/6463 ,  A23D9/013 ,  A23D9/02 ,  C11B3/10 ,  C11C3/10 ,  A23K20/158 ,  A61K8/9706 ,  A61K8/9728 ,  A61K8/99 ,  A61K36/06

Abstract: A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.

公开(公告)号：US20160317592A1

公开(公告)日：2016-11-03

申请号：US15101436

申请日：2014-12-04

Applicant: NIPPON SUISAN KAISHA, LTD.

Inventor： Hideaki YAMAGUCHI ,  Yuhei KOSUGE ,  Rie IKEDA ,  Nobushige DOISAKI ,  Seizo SATO

IPC: A61K36/06 ,  A61K31/202 ,  A23K20/158 ,  A23D9/013 ,  A23D9/02

CPC classification number: A01N37/06 ,  A23D9/013 ,  A23D9/02 ,  A23K20/158 ,  A23L33/115 ,  A61K8/361 ,  A61K8/99 ,  A61K31/202 ,  A61K36/06 ,  A61Q19/00 ,  C11B1/025 ,  C11B3/10 ,  C11B3/12 ,  C11C1/005 ,  C11C3/10 ,  C12N1/28 ,  C12P7/6427 ,  C12P7/6436 ,  C12P7/6463

Abstract: A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.

Abstract translation: 一种微生物油，其包含：特定量的至少一种在脂肪酸烷基酯形式和/或游离脂肪酸形式中具有至少20个碳原子的多不饱和脂肪酸; 特定量的脂肪酸烷基酯形式的碳原子数为16〜22的热产生脂肪酸和/或游离脂肪酸形式。 一种制备方法，其包括：提供含有至少一种具有至少20个碳原子的多不饱和脂肪酸的起始油，其为烷基酯形式和/或由微生物生物质获得的游离脂肪酸形式; 在特定条件下对原油进行整改; 得到上述微生物油。 使用上述制造方法得到的浓缩微生物油及其制造方法。 用于治疗或预防包含微生物油或浓缩微生物油的炎性疾病的药剂。

公开(公告)号：US20220348841A1

公开(公告)日：2022-11-03

申请号：US17860234

申请日：2022-07-08

Applicant: Nippon Suisan Kaisha, Ltd.

Inventor： Yuhei KOSUGE ,  Hideaki YAMAGUCHI ,  Nobushige DOISAKI

IPC: C11C3/00 ,  A23D9/007 ,  C07C69/58 ,  C07C57/12 ,  A61K31/201 ,  A61K31/202 ,  A23L33/12

Abstract: The present disclosure is: a free polyunsaturated fatty acid-containing composition, which comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, the content being at least 80.0% of the fatty acids in the composition, and satisfies at least one selected from a group consisting of conditions (1) and (2): (1) the content of conjugated unsaturated fatty acid is 1.0% or less of the fatty acids in the composition, and (2) the Gardner color is less than 3+; and a manufacturing method for the free polyunsaturated fatty acid-containing composition comprising the preparation of a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms, and hydrolysis of a reaction solution containing the prepared raw material composition, a lower alcohol, water and an alkali catalyst at a temperature of 10° C. or lower.

公开(公告)号：US20180195021A1

公开(公告)日：2018-07-12

申请号：US15906602

申请日：2018-02-27

Applicant: NIPPON SUISAN KAISHA, LTD.

Inventor： Yuhei KOSUGE ,  Hideaki YAMAGUCHI ,  Nobushige DOISAKI

IPC: C11C3/00 ,  A23L33/12

CPC classification number: C11C3/00 ,  A23D9/007 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/201 ,  A61K31/202 ,  C07C57/12 ,  C07C69/58

Abstract: The present disclosure is: a free polyunsaturated fatty acid-containing composition, which comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, the content being at least 80.0% of the fatty acids in the composition, and satisfies at least one selected from a group consisting of conditions (1) and (2): (1) the content of conjugated unsaturated fatty acid is 1.0% or less of the fatty acids in the composition, and (2) the Gardner color is less than 3+; and a manufacturing method for the free polyunsaturated fatty acid-containing composition comprising the preparation of a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms, and hydrolysis of a reaction solution containing the prepared raw material composition, a lower alcohol, water and an alkali catalyst at a temperature of 10° C. or lower.

公开(公告)号：US20210102142A1

公开(公告)日：2021-04-08

申请号：US17124636

申请日：2020-12-17

Applicant: NIPPON SUISAN KAISHA, LTD.

Inventor： Yuhei KOSUGE ,  Hideaki YAMAGUCHI ,  Nobushige DOISAKI

IPC: C11C3/00 ,  A23D9/007 ,  C07C69/58 ,  C07C57/12 ,  A61K31/201 ,  A61K31/202 ,  A23L33/12

Abstract: The present disclosure is: a free polyunsaturated fatty acid-containing composition, which comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, the content being at least 80.0% of the fatty acids in the composition, and satisfies at least one selected from a group consisting of conditions (1) and (2): (1) the content of conjugated unsaturated fatty acid is 1.0% or less of the fatty acids in the composition, and (2) the Gardner color is less than 3+; and a manufacturing method for the free polyunsaturated fatty acid-containing composition comprising the preparation of a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms, and hydrolysis of a reaction solution containing the prepared raw material composition, a lower alcohol, water and an alkali catalyst at a temperature of 10° C. or lower.

公开(公告)号：US20200157465A1

公开(公告)日：2020-05-21

申请号：US16752048

申请日：2020-01-24

Applicant: NIPPON SUISAN KAISHA, LTD.

Inventor： Yuhei KOSUGE ,  Hideaki YAMAGUCHI ,  Nobushige DOISAKI

IPC: C11C3/00 ,  A23D9/007 ,  C07C69/58 ,  C07C57/12 ,  A61K31/201 ,  A61K31/202 ,  A23L33/12

Abstract: The present disclosure is: a free polyunsaturated fatty acid-containing composition, which comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, the content being at least 80.0% of the fatty acids in the composition, and satisfies at least one selected from a group consisting of conditions (1) and (2): (1) the content of conjugated unsaturated fatty acid is 1.0% or less of the fatty acids in the composition, and (2) the Gardner color is less than 3+; and a manufacturing method for the free polyunsaturated fatty acid-containing composition comprising the preparation of a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms, and hydrolysis of a reaction solution containing the prepared raw material composition, a lower alcohol, water and an alkali catalyst at a temperature of 10° C. or lower.

公开(公告)号：US20180187126A1

公开(公告)日：2018-07-05

申请号：US15906645

申请日：2018-02-27

Applicant: NIPPON SUISAN KAISHA, LTD.

Inventor： Hideaki YAMAGUCHI ,  Nobushige DOISAKI ,  Seizo SATO ,  Yuhei KOSUGE

IPC: C11C3/00

CPC classification number: C11C3/00 ,  A23D9/007 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/201 ,  A61K31/202 ,  C07C57/12 ,  C07C69/58

Abstract: Provided is a free-polyunsaturated-fatty-acid-containing composition that has a total metal content of 0.1 ppm or less and that comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, in an amount that is at least 80.0% of the amount of fatty acids in the composition; and a method for manufacturing a free-polyunsaturated-fatty-acid-containing composition, comprising: providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms; performing a hydrolysis treatment on a reaction solution prepared by combining the provided raw material composition, a lower alcohol, water having a total metal content of 0.01 ppm or less, and an alkali catalyst; and limiting the contact between the reaction composition and the metal after the hydrolysis treatment so that the product T [cm2×days] of the contact surface area [cm2] per 1 g and the contact time [days] between the composition and the metal is 100 or less.