公开(公告)号：US5410532A

公开(公告)日：1995-04-25

申请号：US142047

申请日：1993-10-28

Applicant: Masahiro Ono ,  Tsuyoshi Itoh

Inventor： Masahiro Ono ,  Tsuyoshi Itoh

IPC: G01J9/02 ,  G11B7/09 ,  G11B7/22 ,  G11B11/105 ,  G11B7/00 ,  G01B11/26 ,  G01J1/20

CPC classification number: G11B7/22 ,  G01J9/0215 ,  G11B11/10532 ,  G11B11/10576 ,  G11B7/09

Abstract: A method of adjusting a beam splitter of an optical information recording/reproducing apparatus is provided. The optical information recording/reproducing apparatus includes a laser light source, an objective optical system for converging the light beam from the laser light source, a guide rail mechanism for moving the objective optical system, a beam splitter mounted in an optical path of the light beam parallel to the transfer direction and photodetectors for detecting the light beam split by the beam splitter. The method of adjusting the beam splitter includes supporting a supplementary laser source for emitting a laser beam on the guide rail mechanism so that the laser beam of the supplementary laser source is incident onto the beam splitter along the optical path. The method further includes adjusting the beam splitter, while observing the split laser beam from the beam splitter at plural points where the photodetectors are to be mounted.

Abstract translation: 提供一种调整光信息记录/再现装置的分束器的方法。 光信息记录/再现装置包括激光源，用于会聚来自激光光源的光束的物镜光学系统，用于移动物镜光学系统的导轨机构，安装在光的光路中的分束器 平行于传送方向的光束和用于检测由分束器分裂的光束的光电检测器。 调整分束器的方法包括：支撑用于在导轨机构上发射激光束的辅助激光源，使得辅助激光源的激光束沿着光路入射到分束器上。 该方法还包括调整分束器，同时在要安装光电检测器的多个点处观察来自分束器的分离激光束。

公开(公告)号：US09072204B2

公开(公告)日：2015-06-30

申请号：US13384502

申请日：2010-07-15

Applicant: Ryo Kuwabara ,  Atsushi Yamaguchi ,  Masahiro Ono ,  Hidenori Miyakawa

Inventor： Ryo Kuwabara ,  Atsushi Yamaguchi ,  Masahiro Ono ,  Hidenori Miyakawa

IPC: H05K3/28 ,  H01L21/56 ,  H01L23/31 ,  H01L23/552 ,  H01L25/16 ,  H05K1/02 ,  H05K1/03

CPC classification number: H05K3/284 ,  H01L21/561 ,  H01L21/565 ,  H01L23/3121 ,  H01L23/552 ,  H01L25/165 ,  H01L2224/16225 ,  H01L2924/01019 ,  H01L2924/3025 ,  H01L2924/3511 ,  H05K1/0218 ,  H05K1/0313 ,  H05K2203/1316

Abstract: An electronic module 10 includes: a circuit board 12 having a first surface and a second surface opposite the first surface; and a plurality of electronic components 14 mounted thereon. The electronic components 14 are sealed at the first surface of the circuit board 12, with a mold body 16 composed of a resin composition. A shield layer 28 is formed on the surface of the mold body 16. The glass transition temperature of a resin included in the mold body 16 is higher than the glass transition temperatures of resins included in the circuit board 12 and the shield layer 28, respectively. The modulus of elasticity of the mold body at 25° C. is 10 to 18 GPa, and the thickness of the circuit board is 0.3 to 1.0 mm.

Abstract translation: 电子模块10包括：具有第一表面和与第一表面相对的第二表面的电路板12; 以及安装在其上的多个电子部件14。 电子部件14被密封在电路板12的第一表面，模具体16由树脂组合物构成。 屏蔽层28形成在模体16的表面上。包括在模体16中的树脂的玻璃化转变温度分别高于包括在电路板12和屏蔽层28中的树脂的玻璃化转变温度 。 模具体在25℃下的弹性模量为10〜18GPa，电路基板的厚度为0.3〜1.0mm。

公开(公告)号：US09044520B2

公开(公告)日：2015-06-02

申请号：US13434722

申请日：2012-03-29

Applicant: Hideo Saji ,  Hiroyuki Kimura ,  Masahiro Ono ,  Ikuya Seki

Inventor： Hideo Saji ,  Hiroyuki Kimura ,  Masahiro Ono ,  Ikuya Seki

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/08

CPC classification number: A61K51/088 ,  G01N2800/042

Abstract: Embodiments of the invention provide a compound accumulating in an inflammatory site, a diagnostic agent containing the compound in labeled state and its precursor compound for labeling. Such a compound accumulating in inflammatory site may be represented by the following formula (1): Z—Y-Leu-Phe-(X)n-DLys(-(DLys)m-HalB)-(DLys)k-NH2  (1) wherein in the formula (1), Z represents a protective group for an amino group; Y represents Met or Nle; X represents a spacer consisting of one or more of amino acid and/or synthetic organic compounds; n represents 1 or 0; m represents 1 or 0; k represents 1 or 0; and HalB represents a substituted benzoic acid having a radioactive halogen in an aromatic ring.

Abstract translation: 本发明的实施方案提供了一种在炎症部位中积聚的化合物，含有标记状态的化合物的诊断剂及其用于标记的前体化合物。 Z-Y-Leu-Phe-（X）n-DLys（ - （DLys）m-HalB） - （DLys）k-NH 2（1）的化合物可以由下述式（1）表示： ）其中在式（1）中，Z表示氨基的保护基; Y表示Met或Nle; X表示由一种或多种氨基酸和/或合成有机化合物组成的间隔物; n表示1或0; m表示1或0; k表示1或0; HalB表示在芳香环中具有放射性卤素的取代苯甲酸。

公开(公告)号：US20130149252A1

公开(公告)日：2013-06-13

申请号：US13818392

申请日：2011-08-08

Applicant: Isao Hara ,  Eiichi Ozeki ,  Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma

Inventor： Isao Hara ,  Eiichi Ozeki ,  Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma

IPC: A61K49/00

CPC classification number: A61K49/0089 ,  A61K49/0032 ,  A61K49/0093 ,  Y10S977/773 ,  Y10S977/927

Abstract: The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.

Abstract translation: 本发明提供了具有开关功能（在纳米颗粒制备期间淬灭荧光染料并在成像期间发射荧光的功能）的新型荧光纳米颗粒成像探针。 一种开关荧光纳米颗粒探针，包括：由具有亲水嵌段链和疏水性嵌段链的两亲嵌段聚合物组成的分子组合; 以及包封在分子组合中的荧光染料，其中（a）所述亲水性嵌段链包含作为必需亲水性结构单元的选自肌氨酸单元和烯化氧单元的单元，（b）所述疏水性嵌段链包含： 必需的疏水结构单元，选自氨基酸单元和羟基酸单元的单元，和（c）荧光染料是由式（I）表示的花青化合物：和 荧光染料被封装在单分子组装中。

公开(公告)号：US20120330024A1

公开(公告)日：2012-12-27

申请号：US13582047

申请日：2011-02-24

Applicant: Hideo Saji ,  Masahiro Ono ,  Ikuya Seki

Inventor： Hideo Saji ,  Masahiro Ono ,  Ikuya Seki

IPC: C07D405/06 ,  C07F7/22 ,  C07D405/14 ,  C07D417/06 ,  C07D417/14

CPC classification number: C07D417/06 ,  A61K51/0453 ,  C07D405/06 ,  C07D405/14

Abstract: The present invention is a compound represented by the following formula (1) or a salt thereof. Furthermore, the present invention is an imaging agent used for imaging a tau protein, the imaging agent containing a compound represented by the formula (1) below or a salt thereof. In the formula (1), R3 is a radioactive iodine.

Abstract translation: 本发明是由下式（1）表示的化合物或其盐。 此外，本发明是用于成像tau蛋白的成像剂，该成像剂含有下述式（1）表示的化合物或其盐。 在式（1）中，R 3是放射性碘。

公开(公告)号：US20120253010A1

公开(公告)日：2012-10-04

申请号：US13434722

申请日：2012-03-29

Applicant: Hideo Saji ,  Hiroyuki Kimura ,  Masahiro Ono ,  Ikuya Seki

Inventor： Hideo Saji ,  Hiroyuki Kimura ,  Masahiro Ono ,  Ikuya Seki

IPC: C07K7/06

CPC classification number: A61K51/088 ,  G01N2800/042

Abstract: Embodiments of the invention provide a compound accumulating in an inflammatory site, a diagnostic agent containing the compound in labeled state and its precursor compound for labeling. Such a compound accumulating in inflammatory site may be represented by the following formula (1): Z—Y-Leu-Phe-(X)n-DLys(-(DLys)m-HalB)-(DLys)k-NH2  (1) wherein in the formula (1), Z represents a protective group for an amino group; Y represents Met or Nle; X represents a spacer consisting of one or more of amino acid and/or synthetic organic compounds; n represents 1 or 0; m represents 1 or 0; k represents 1 or 0; and HalB represents a substituted benzoic acid having a radioactive halogen in an aromatic ring.

Abstract translation: 本发明的实施方案提供了一种在炎症部位中积聚的化合物，含有标记状态的化合物的诊断剂及其用于标记的前体化合物。 Z-Y-Leu-Phe-（X）n-DLys（ - （DLys）m-HalB） - （DLys）k-NH 2（1）的化合物可以由下述式（1）表示： ）其中在式（1）中，Z表示氨基的保护基; Y表示Met或Nle; X表示由一种或多种氨基酸和/或合成有机化合物组成的间隔物; n表示1或0; m表示1或0; k表示1或0; HalB表示在芳香环中具有放射性卤素的取代苯甲酸。

公开(公告)号：US07833041B2

公开(公告)日：2010-11-16

申请号：US12421450

申请日：2009-04-09

Applicant: Masahiro Ono ,  Masayuki Okamoto

Inventor： Masahiro Ono ,  Masayuki Okamoto

IPC: H01R13/62

CPC classification number: H01R12/88 ,  H01R12/774

Abstract: A connector has a base having an opening to be inserted with a tip portion of a flexible printed circuit board at a front surface, and having a plurality of insertion holes passing from the front surface to a rear surface juxtaposed at a predetermined pitch, a connection terminal arranged in a projecting manner with a substantially T-shaped operating piece having at one end a movable contacting point that comes into pressure contact with joints juxtaposed at the tip portion of the flexible printed circuit board, the connection terminal having one end that becomes a fixed contacting point inserted to the insertion hole from the rear surface side, and an operating lever in which a cam portion is fitted into a turning recessed portion arranged at an upper side of the connection terminal to act as a turning supporting point, the cam portion driving an operation receiving portion positioned at the other end of the operating piece. A position regulation contacting portion arranged at a lower surface of the operating lever locks to a slip-out preventing projection arranged in a projecting manner at an upper side of the connection terminal to prevent slip-out when the operating lever is turned and a locking operation is completed.

Abstract translation: 连接器具有基部，其具有在前表面插入柔性印刷电路板的前端部的开口，并且具有从前表面延伸到以预定间距并置的后表面的多个插入孔，连接 端子布置成具有基本上T形的操作件的基本上T形的操作件，其一端具有与在柔性印刷电路板的顶端部分并列的接头进行压力接触的可动接触点，连接端子的一端变为 固定接触点从后表面侧插入插入孔;以及操作杆，其中凸轮部分装配到布置在连接端子的上侧的转向凹部中，以用作转动支撑点，凸轮部分 驱动位于操作件的另一端的操作接收部。 布置在操作杆的下表面处的位置调节接触部分锁定到突出地布置在连接端子的上侧的防滑突起，以防止当操作杆转动时滑脱，并且锁定操作 完成了。

公开(公告)号：US20100278733A1

公开(公告)日：2010-11-04

申请号：US12301805

申请日：2007-05-22

Applicant: Morio Nakayama ,  Mamoru Haratake ,  Masahiro Ono

Inventor： Morio Nakayama ,  Mamoru Haratake ,  Masahiro Ono

IPC: A61K49/00 ,  A61K51/00 ,  A61P43/00 ,  C07D213/61 ,  C07D333/22 ,  C07C211/00 ,  C07D277/30 ,  C07D233/54

CPC classification number: C07D213/61 ,  A61K51/04 ,  A61K51/0431 ,  A61K51/0455 ,  C07D213/60 ,  C07D233/64 ,  C07D277/24 ,  C07D307/42 ,  C07D333/28 ,  C07D333/36 ,  C07D409/06

Abstract: There is provided a composition comprising a compound represented by general formula (I), wherein Rl represents a 5-iodothiophen-2-yl group or the like, and R2 represents a 4-dimethylaminophenyl group or the like. This composition is useful for diagnosis of an amyloid-related disease such as Alzheimer's disease because the compound has high binding specificity to amyloid β protein, high permeability through the blood-brain barrier, and a property of being rapidly eliminated from sites other than senile plaques in the brain.

Abstract translation: 提供了包含由通式（I）表示的化合物的组合物，其中R1表示5-碘代噻吩-2-基等，R2表示4-二甲基氨基苯基等。 该组合物可用于淀粉样蛋白相关疾病如阿尔茨海默病的诊断，因为该化合物对淀粉样蛋白和bgr具有高结合特异性; 蛋白质，通过血脑屏障的高渗透性，以及从脑中除老年斑之外的部位迅速消除的性质。

公开(公告)号：US20100187675A1

公开(公告)日：2010-07-29

申请号：US12692872

申请日：2010-01-25

Applicant: Kazumichi Shimizu ,  Yoshihiro Tomura ,  Masahiro Ono

Inventor： Kazumichi Shimizu ,  Yoshihiro Tomura ,  Masahiro Ono

IPC: H01L23/48 ,  H01L21/60

CPC classification number: H01L21/563 ,  H01L21/561 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/73203 ,  H01L2224/73204 ,  H01L2924/00011 ,  H01L2924/00014 ,  H01L2924/1815 ,  H01L2924/00 ,  H01L2224/0401

Abstract: This semiconductor device is a semiconductor device in which a semiconductor element is flip-chip mounted onto a circuit substrate and the semiconductor element is covered and sealed with a sealing resin. A recess portion is formed in the sealing resin on a surface opposite to the mounting surface of the semiconductor element. Warping of the semiconductor device is reduced by the action of this recess portion.

Abstract translation: 该半导体装置是将半导体元件倒装芯片安装在电路基板上的半导体装置，半导体元件被密封树脂​​覆盖并密封。 在与半导体元件的安装表面相对的表面上的密封树脂中形成凹部。 通过该凹部的作用可以减小半导体器件的翘曲。

公开(公告)号：US20090215287A1

公开(公告)日：2009-08-27

申请号：US11918121

申请日：2006-07-06

Applicant: Masato Mori ,  Yoshihiko Yagi ,  Masahiro Ono ,  Yoshihiro Tomura ,  Kunio Hibino ,  Yasushi Nakagiri ,  Akihiro Miyashita ,  Kunio Sakurai

Inventor： Masato Mori ,  Yoshihiko Yagi ,  Masahiro Ono ,  Yoshihiro Tomura ,  Kunio Hibino ,  Yasushi Nakagiri ,  Akihiro Miyashita ,  Kunio Sakurai

IPC: H01R12/14

CPC classification number: H05K3/368 ,  H05K1/0271 ,  H05K1/144 ,  H05K1/145 ,  H05K2201/042 ,  H05K2201/09036 ,  H05K2201/09163 ,  H05K2201/2018

Abstract: A substrate connecting member connects two circuit boards connected together while maintaining high reliability of the junctions between itself and the circuit boards even if the circuit boards are warped by temperature change of an impact load. The substrate connecting member includes a frame member made of an insulating resin; slit grooves formed in at least one of the inner and outer surfaces of frame side portions composing the frame member, the slit grooves being formed throughout the entire length of the frame side portions in the direction perpendicular to the thickness direction of the frame side portions; and connection conductor portions having connection terminals provided on the top and bottom surfaces, respectively, of the frame side portions in the thickness direction and connecting conductors each connecting connection terminals.

Abstract translation: 衬底连接构件连接两个连接在一起的电路板，同时保持其自身和电路板之间的接合部的高可靠性，即使电路板由于冲击负载的温度变化而翘曲。 基板连接构件包括由绝缘树脂制成的框架构件; 狭缝槽形成在构成框架构件的框架侧部的至少一个内表面和外表面中，狭缝槽沿与框架侧部的厚度方向垂直的方向在框架侧部分的整个长度上形成; 以及连接导体部分，其具有分别设置在厚度方向上的框架侧部分的顶表面和底表面上的连接端子和连接连接端子的连接导体。