-
公开(公告)号：US20140037647A1
公开(公告)日：2014-02-06
申请号：US14112358
申请日：2012-03-28
Applicant: Mark A. Rubin , Himisha Beltran
Inventor： Mark A. Rubin , Himisha Beltran
CPC classification number: G01N33/6893 , A61K31/00 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/675 , A61K31/713 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , G01N33/57434 , G01N2333/82 , G01N2333/91215
Abstract: Disclosed herein are new prognostic molecular markers for prostate cancer. More specifically, the invention has identified that overexpression or amplification of at least one of AURKA or MYCN define a distinct subgroup of prostate cancer that is predisposed to the development of lethal NEPC, who will benefit from early intervention.
Abstract translation: 本文公开了用于前列腺癌的新的预后分子标记。 更具体地，本发明已经确定，AURKA或MYCN中的至少一种的过度表达或扩增定义了易于发生致死性NEPC的前列腺癌的不同亚组，其将受益于早期干预。
-
公开(公告)号：US09568483B2
公开(公告)日：2017-02-14
申请号：US14112358
申请日：2012-03-28
Applicant: Mark A. Rubin , Himisha Beltran
Inventor： Mark A. Rubin , Himisha Beltran
IPC: C12Q1/68 , C07H21/04 , G01N33/68 , G01N33/574 , A61K31/00 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/675 , A61K31/713
CPC classification number: G01N33/6893 , A61K31/00 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/675 , A61K31/713 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , G01N33/57434 , G01N2333/82 , G01N2333/91215
Abstract: Disclosed herein are new prognostic molecular markers for prostate cancer. More specifically, the invention has identified that overexpression or amplification of at least one of AURKA or MYCN define a distinct subgroup of prostate cancer that is predisposed to the development of lethal NEPC, who will benefit from early intervention.
Abstract translation: 本文公开了用于前列腺癌的新的预后分子标记。 更具体地，本发明已经确定，AURKA或MYCN中的至少一种的过度表达或扩增定义了易于发生致死性NEPC的前列腺癌的不同亚组，其将受益于早期干预。
-
3.发明申请COMPOSITIONS AND METHODS FOR DIAGNOSING PROSTATE CANCER BASED ON DETECTION OF SLC45A3-ELK4 FUSION TRANSCRIPT 有权基于检测SLC45A3-ELK4融合转录物检测前列腺癌的组合物和方法公开(公告)号：US20120039887A1
公开(公告)日：2012-02-16
申请号：US13202207
申请日：2010-02-19
Applicant: Mark A. Rubin , Dorothee Pflueger , David S. Rickman
Inventor： Mark A. Rubin , Dorothee Pflueger , David S. Rickman
IPC: A61K39/395 , A61P35/00 , C12Q1/18 , C07H21/00 , C07K16/18 , A61K31/7088 , C12Q1/68
CPC classification number: C07K14/4748 , C12N15/62 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156
Abstract: RNA transcripts representing a fusion of a human SLC45A3 nucleic acid and a human ELK4 nucleic acid that are associated with prostate cancer are described. Compositions and methods useful for detection of fusion transcripts of human SLC45A3 and ELK4 genetic sequences associated with cancer and useful for cancer therapy are provided.
Abstract translation: 描述代表人类SLC45A3核酸和与前列腺癌相关的人ELK4核酸的融合物的RNA转录物。 提供了可用于检测与癌症相关的人类SLC45A3和ELK4遗传序列的融合转录物并可用于癌症治疗的组合物和方法。
-
公开(公告)号：US20110034677A1
公开(公告)日：2011-02-10
申请号：US12650164
申请日：2009-12-30
Applicant: Scott Tomlins , Daniel Rhodes , Arul Chinnaiyan , Rohit Mehra , Mark A. Rubin , Xiao-Wei Sun , Sven Perner , Charles Lee , Francesca Demichelis
Inventor： Scott Tomlins , Daniel Rhodes , Arul Chinnaiyan , Rohit Mehra , Mark A. Rubin , Xiao-Wei Sun , Sven Perner , Charles Lee , Francesca Demichelis
CPC classification number: C12Q1/6886 , A01K67/0275 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C07K2319/00 , C12N9/6424 , C12N9/6445 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57434 , Y10S435/81
Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
Abstract translation: 描述了前列腺癌中雄激素调节基因和ETS家族成员基因的复发基因融合。 还提供了在前列腺癌诊断，研究和治疗中具有效用的组合物和方法。
-
公开(公告)号：US07767393B2
公开(公告)日：2010-08-03
申请号：US11343797
申请日：2006-01-31
Applicant: Arul M. Chinnaiyan , Mark A. Rubin , Arun Sreekumar
Inventor： Arul M. Chinnaiyan , Mark A. Rubin , Arun Sreekumar
CPC classification number: G01N33/57434 , C12Q1/6886 , C12Q2600/158 , Y10S436/811 , Y10S436/813
Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of prostate cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
-
Patent Agency Ranking
公开(公告)号：US09284609B2
公开(公告)日：2016-03-15
申请号：US13483157
申请日：2012-05-30
Applicant: Scott Tomlins , Daniel Rhodes , Arul Chinnaiyan , Rohit Mehra , Mark A. Rubin , Xiao-Wei Sun , Sven Perner , Charles Lee , Francesca Demichelis
Inventor： Scott Tomlins , Daniel Rhodes , Arul Chinnaiyan , Rohit Mehra , Mark A. Rubin , Xiao-Wei Sun , Sven Perner , Charles Lee , Francesca Demichelis
IPC: C12P19/34 , C07H21/04 , C12Q1/68 , C12N15/113 , G01N33/574
CPC classification number: C12Q1/6886 , A01K67/0275 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C07K2319/00 , C12N9/6424 , C12N9/6445 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57434 , Y10S435/81
Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
-
公开(公告)号：US08211645B2
公开(公告)日：2012-07-03
申请号：US12650164
申请日：2009-12-30
Applicant: Scott Tomlins , Daniel Rhodes , Arul Chinnaiyan , Rohit Mehra , Mark A. Rubin , Xiao-Wei Sun , Sven Perner , Charles Lee , Francesca Demichelis
Inventor： Scott Tomlins , Daniel Rhodes , Arul Chinnaiyan , Rohit Mehra , Mark A. Rubin , Xiao-Wei Sun , Sven Perner , Charles Lee , Francesca Demichelis
CPC classification number: C12Q1/6886 , A01K67/0275 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C07K2319/00 , C12N9/6424 , C12N9/6445 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57434 , Y10S435/81
Abstract: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.
Abstract translation: 描述了前列腺癌中雄激素调节基因和ETS家族成员基因的复发基因融合。 还提供了在前列腺癌诊断，研究和治疗中具有效用的组合物和方法。
-
公开(公告)号：US10443102B2
公开(公告)日：2019-10-15
申请号：US14000484
申请日：2012-02-09
Applicant: Mark A. Rubin , Christopher Barbieri
Inventor： Mark A. Rubin , Christopher Barbieri
IPC: C12Q1/6886 , G01N33/574
Abstract: The invention relates generally to new prostate cancer markers, and particularly to a class of cancer marked by the presence of missense mutations in SPOP, an E3 ubiquitin ligase component. The invention provides methods and materials for detecting and diagnosing prostate cancer by detecting these mutations and may be useful in predicting disease progression and response to therapy.
-
9.发明授权Compositions and methods for diagnosing prostate cancer based on detection of SLC45A3-ELK4 fusion transcript 有权基于检测SLC45A3-ELK4融合转录物诊断前列腺癌的组合物和方法公开(公告)号：US09458213B2
公开(公告)日：2016-10-04
申请号：US13202207
申请日：2010-02-19
Applicant: Mark A. Rubin , Dorothee Pflueger , David S. Rickman
Inventor： Mark A. Rubin , Dorothee Pflueger , David S. Rickman
CPC classification number: C07K14/4748 , C12N15/62 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156
Abstract: RNA transcripts representing a fusion of a human SLC45A3 nucleic acid and a human ELK4 nucleic acid that are associated with prostate cancer are described. Compositions and methods useful for detection of fusion transcripts of human SLC45A3 and ELK4 genetic sequences associated with cancer and useful for cancer therapy are provided.
Abstract translation: 描述代表人类SLC45A3核酸和与前列腺癌相关的人ELK4核酸的融合物的RNA转录物。 提供了可用于检测与癌症相关的人类SLC45A3和ELK4遗传序列的融合转录物并可用于癌症治疗的组合物和方法。
-
10.发明授权Methods of diagnosing and treating prostate cancer characterized by NDRG1-ERG fusion 有权以NDRG1-ERG融合为特征的前列腺癌诊断和治疗方法公开(公告)号：US09090899B2
公开(公告)日：2015-07-28
申请号：US13254071
申请日：2010-03-08
Applicant: Mark A. Rubin , Dorothee Pflueger , David S. Rickman
Inventor： Mark A. Rubin , Dorothee Pflueger , David S. Rickman
CPC classification number: C12N15/62 , A61K38/00 , C07K14/47 , C07K14/82 , C12Q1/6886 , G01N33/57434
Abstract: An in depth analysis of prostate cancer prostatectomy samples which over-express the ERG oncogene led to the discovery of a novel gene translocation in prostate cancer, between the NDRG1 gene (N-myc downstream regulated gene 1) on chromosome 8 and the ERG oncogene on chromosome 21, leading to the expression of a chimeric NDRG1-ERG protein. Methods and compositions useful for diagnosing and treating prostate cancer characterized by NDRG1-ERG fusion are described.
Abstract translation: 对过表达ERG癌基因的前列腺癌前列腺切除术样品的深入分析导致在8号染色体上的NDRG1基因（N-myc下游调节基因1）和ERG致癌基因之间在前列腺癌中发现新的基因易位 染色体21，导致嵌合NDRG1-ERG蛋白的表达。 描述了用于诊断和治疗以NDRG1-ERG融合为特征的前列腺癌的方法和组合物。
-
-
-
-
-
-
-
-
-
Search Results
25
records
(took 0.063 seconds)
