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公开(公告)号：US20220249600A1
公开(公告)日：2022-08-11
申请号：US17657885
申请日：2022-04-04
Applicant: MOREHOUSE SCHOOL OF MEDICINE
Inventor： Vincent C. BOND , Michael POWELL , Ming Bo HUANG , Syed ALI , Martin N. SHELTON
Abstract: The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
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公开(公告)号：US20220193206A1
公开(公告)日：2022-06-23
申请号：US17585022
申请日：2022-01-26
Applicant: Morehouse School of Medicine
Inventor： Michael POWELL , Erick Vidjin' Agnih GBODOSSOU
Abstract: The present application relates to a compositions and methods comprising or expressing a HEVAR or MOMO30 protein derived from Momordica balsamina. The HEVAR or MOMO30 protein and/or a nucleic acid encoding the same may be used in methods for treating or preventing viral infections, particularly those caused by coronaviruses, such as SARS-CoV-2.
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公开(公告)号：US20220395548A1
公开(公告)日：2022-12-15
申请号：US17660967
申请日：2022-04-27
Applicant: MOREHOUSE SCHOOL OF MEDICINE
Inventor： Michael POWELL , Erick Vidjin' Agnih GBODOSSOU
Abstract: The present application relates to a compositions and methods comprising or expressing a hevamine A-related MoMo30 protein from Momordica balsamina. The MoMo30 protein is about 30 kDa in size, is stable after being autoclaved at 120° C. for 30 min, resists proteolytic cleavage by trypsin, exhibits mannose-sensitive binding to HIV gp120, exhibits hemagglutinin and chitinase activity, is capable of activating and stimulating T cell proliferation, is capable of preventing infection by HIV-1 or alleviating symptoms in an HIV-1 infected patients, and comprises an amino acid sequence of SEQ ID NO: 4. The MoMo30 protein and/or a nucleic acid encoding the same may be used in methods for preventing or treating microbial infections by HIV, SARS-CoV-2 and other enveloped viruses, as well as other microorganisms comprising cell surface proteins containing glycan residues, such as mannose.
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公开(公告)号：US20170369533A1
公开(公告)日：2017-12-28
申请号：US15660572
申请日：2017-07-26
Applicant: MOREHOUSE SCHOOL OF MEDICINE
Inventor： Vincent C. Bond , Michael POWELL , Ming Bo HUANG , Syed ALI
IPC: C07K14/005 , A61K38/16 , A61K39/39 , A61K45/06 , C07K14/16 , G01N33/566 , A61K9/127 , C12P21/02 , G01N33/543 , C12N15/00 , A61K38/00 , A61K39/00
CPC classification number: C07K14/005 , A61K9/127 , A61K38/00 , A61K38/162 , A61K39/39 , A61K45/06 , A61K2039/55555 , C07K14/163 , C07K2319/055 , C07K2319/50 , C07K2319/60 , C12N15/00 , C12N2740/16322 , C12P21/02 , G01N33/543 , G01N33/566
Abstract: The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US20140120156A2
公开(公告)日：2014-05-01
申请号：US14019601
申请日：2013-09-06
Applicant: Morehouse School of Medicine
Inventor： Vincent Craig BOND , Michael POWELL , MingBo HUANG , Syed ALI
IPC: C07K14/005 , G01N33/566 , A61K39/39 , A61K45/06 , A61K9/127 , A61K38/16
CPC classification number: C07K14/005 , A61K9/127 , A61K38/00 , A61K38/162 , A61K39/39 , A61K45/06 , A61K2039/55555 , C07K14/163 , C07K2319/055 , C07K2319/50 , C07K2319/60 , C12N15/00 , C12N2740/16322 , C12P21/02 , G01N33/543 , G01N33/566
Abstract: The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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Patent Agency Ranking
公开(公告)号：US20240325481A1
公开(公告)日：2024-10-03
申请号：US18432324
申请日：2024-02-05
Applicant: MOREHOUSE SCHOOL OF MEDICINE
Inventor： Michael POWELL , Erick Vidjin’ Agnih GBODOSSOU
IPC: A61K36/42 , A01N63/50 , A01P1/00 , A61K31/352 , A61K33/30 , A61K38/47 , A61P31/18 , C12N15/10 , C12N15/82 , C12P19/34
CPC classification number: A61K36/42 , A01N63/50 , A01P1/00 , A61K31/352 , A61K33/30 , A61K38/47 , A61P31/18 , C12N15/1096 , C12N15/8283 , C12P19/34 , C07K2319/01
Abstract: In one aspect, nutraceutical compositions, methods of preparation and methods of use comprise a nutraceutical composition comprising an antimicrobial hevamine A-related protein from Momordica balsamina alone or in combination with one or more nutraceutical ingredients. In another aspect, a method of preventing or treating a microbial infection in a plant comprises applying an effective amount of a composition containing the hevamine A-related protein to a whole plant, plant part, or media in which the plant is growing. In a further aspect, the present application provides a transgenic plant stably transformed with a polynucleotide encoding the hevamine A-related protein.
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公开(公告)号：US20210000914A1
公开(公告)日：2021-01-07
申请号：US16947808
申请日：2020-08-18
Applicant: MOREHOUSE SCHOOL OF MEDICINE
Inventor： Vincent C. BOND , Michael POWELL , Ming Bo HUANG , Syed ALI , Martin N. SHELTON
Abstract: The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
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公开(公告)号：US20220401527A1
公开(公告)日：2022-12-22
申请号：US17805753
申请日：2022-06-07
Applicant: Morehouse School of Medicine
Inventor： Michael POWELL , Erick Vidjin' Agnih Gbodossou
Abstract: In one aspect, nutraceutical compositions, methods of preparation and methods of use comprise a nutraceutical composition comprising an antimicrobial hevamine A-related protein from Momordica balsamina alone or in combination with one or more nutraceutical ingredients. In another aspect, a method of preventing or treating a microbial infection in a plant comprises applying an effective amount of a composition containing the hevamine A-related protein to a whole plant, plant part, or media in which the plant is growing. In a further aspect, the present application provides a transgenic plant stably transformed with a polynucleotide encoding the hevamine A-related protein.
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公开(公告)号：US20220054601A1
公开(公告)日：2022-02-24
申请号：US17342897
申请日：2021-06-09
Applicant: MOREHOUSE SCHOOL OF MEDICINE
Inventor： Michael POWELL , Erick Vidjin' Agnih Gbodossou
Abstract: The present application relates to a compositions and methods comprising or expressing a HEVAR or MOMO30 protein derived from Momordica balsamina. The HEVAR or MOMO30 protein and/or a nucleic acid encoding the same may be used in methods for treating or preventing viral infections, particularly those caused by coronaviruses, such as SARS-CoV-2.
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10.发明申请公开(公告)号：US20140121170A2
公开(公告)日：2014-05-01
申请号：US14015438
申请日：2013-08-30
Applicant: Morehouse School of Medicine
Inventor： Vincent Craig BOND , Michael POWELL , MingBo HUANG , Syed ALI , Andrea D. RAYMOND , Martin Neville SHELTON , Francois Jean VILLINGER
CPC classification number: C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
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