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公开(公告)号：US20220193206A1
公开(公告)日：2022-06-23
申请号：US17585022
申请日：2022-01-26
Applicant: Morehouse School of Medicine
Inventor： Michael POWELL , Erick Vidjin' Agnih GBODOSSOU
Abstract: The present application relates to a compositions and methods comprising or expressing a HEVAR or MOMO30 protein derived from Momordica balsamina. The HEVAR or MOMO30 protein and/or a nucleic acid encoding the same may be used in methods for treating or preventing viral infections, particularly those caused by coronaviruses, such as SARS-CoV-2.
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公开(公告)号：US20220395548A1
公开(公告)日：2022-12-15
申请号：US17660967
申请日：2022-04-27
Applicant: MOREHOUSE SCHOOL OF MEDICINE
Inventor： Michael POWELL , Erick Vidjin' Agnih GBODOSSOU
Abstract: The present application relates to a compositions and methods comprising or expressing a hevamine A-related MoMo30 protein from Momordica balsamina. The MoMo30 protein is about 30 kDa in size, is stable after being autoclaved at 120° C. for 30 min, resists proteolytic cleavage by trypsin, exhibits mannose-sensitive binding to HIV gp120, exhibits hemagglutinin and chitinase activity, is capable of activating and stimulating T cell proliferation, is capable of preventing infection by HIV-1 or alleviating symptoms in an HIV-1 infected patients, and comprises an amino acid sequence of SEQ ID NO: 4. The MoMo30 protein and/or a nucleic acid encoding the same may be used in methods for preventing or treating microbial infections by HIV, SARS-CoV-2 and other enveloped viruses, as well as other microorganisms comprising cell surface proteins containing glycan residues, such as mannose.
